A5057928840- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Alkaloids: synthesis and pharmacology
- Coordination Chemistry and Organometallics
- Synthesis and bioactivity of alkaloids
- Synthetic Organic Chemistry Methods
- Advanced Synthetic Organic Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Microbial Natural Products and Biosynthesis
- Heat Transfer Mechanisms
- Tribology and Lubrication Engineering
- Chemical synthesis and alkaloids
- Cancer Treatment and Pharmacology
Tohoku University
1995-2023
Nanyang Technological University
2017
Mitsubishi Electric (United States)
2007
Abstract A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in presence lithium iodide (LiI). This offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that reaction proceeds through unusual concerted aromatic substitution.
Biomimetic oxidative dimerization of tryptophan derivatives in aqueous media with oxygen as a bulk oxidant catalyzed by an iron octacarboxy phthalocyanine complex was established. The discovery the extremely active catalyst enables aerobic enzyme-mimetic oxidation to be performed flask. This method applicable wide range derivatives, including various dipeptides and oligopeptides, remarkable functional-group tolerance without protection amino acid residues. Furthermore, bearing...
Abstract A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in presence lithium iodide (LiI). This offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that reaction proceeds through unusual concerted aromatic substitution.
A protocol for the allylation at C3a-position of hexahydropyrroloindole using allylsilanes is developed. AgNTf2 proved to be an efficient activator halopyrroloindoline substrates. This method applicable introduction various allyl groups including reverse prenyl group. The utility this reaction demonstrated by total synthesis amauromine alkaloids. Stepwise bromocyclizations bis-indolylmethyl diketopiperazine derivative and subsequent double prenylation furnished (+)-novoamauromine (-)-epiamauromine.
An N-linked indole structure was constructed on the 3a-position of pyrroloindoline derivatives via a cascade process involving silver-mediated amination bromopyrroloindolines with 2-ethynylanilines subsequent 5-endo-dig cyclization. In this reaction, AgNTf2 used as tandem reagent, which activated bromo group σ-Lewis acid and alkyne moiety π-Lewis acid. Switching from initial step to second conducted by controlling temperature. This protocol applied synthesis various pyrroloindolines,...
Abstract Biomimetic oxidative dimerization of tryptophan derivatives in aqueous media with oxygen as a bulk oxidant catalyzed by an iron octacarboxy phthalocyanine complex was established. The discovery the extremely active catalyst enables aerobic enzyme‐mimetic oxidation to be performed flask. This method applicable wide range derivatives, including various dipeptides and oligopeptides, remarkable functional‐group tolerance without protection amino acid residues. Furthermore, bearing...
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