A5015256294- Gut microbiota and health
- Probiotics and Fermented Foods
- Sarcoma Diagnosis and Treatment
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Ginseng Biological Effects and Applications
- Non-Destructive Testing Techniques
- Semiconductor materials and devices
- Integrated Circuits and Semiconductor Failure Analysis
- Geophysical Methods and Applications
- Hip disorders and treatments
- Digestive system and related health
- Ultrasonics and Acoustic Wave Propagation
- Semiconductor materials and interfaces
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Urologic and reproductive health conditions
- Peptidase Inhibition and Analysis
- Fecal contamination and water quality
- Testicular diseases and treatments
- Protein Degradation and Inhibitors
- Heparin-Induced Thrombocytopenia and Thrombosis
- Musculoskeletal synovial abnormalities and treatments
- Tuberous Sclerosis Complex Research
- Helminth infection and control
Morinaga (Japan)
2010-2025
Megmilk Snow Brand (Japan)
2018-2025
Nippon Medical School
2024
Mie University
2013-2022
Royal College of Surgeons in Ireland
2011
University College Dublin
2011
Tallaght University Hospital
2011
St. Vincent's University Hospital
2011
Beaumont Hospital
2011
Mater Misericordiae University Hospital
2011
The human gut microbiota established during infancy has persistent effects on health. In vitro studies have suggested that milk oligosaccharides (HMOs) in breast promote the formation of a bifidobacteria-rich infant guts; however, underlying molecular mechanism remains elusive. Here, we characterized two functionally distinct but overlapping fucosyllactose transporters (FL transporter-1 and -2) from Bifidobacterium longum subspecies infantis. Fecal DNA HMO consumption analyses, combined with...
Bifidobacterium longum subsp. represents one of the most prevalent bifidobacterial species in infant, adult and elderly (human) gut. In current study, we performed a comparative genome analysis involving 145 B. representatives, including 113 strains obtained from healthy Japanese subjects aged between 0 98 years. Although MCL clustering did not reveal any correlation isolated subject age, certain characteristics appear to be more among corresponding specific host ages, such as genes involved...
Bifidobacteria are among the first colonizers of infant gut, and human milk oligosaccharides (HMOs) in breastmilk instrumental for formation a bifidobacteria-rich microbiota. However, little is known about assembly bifidobacterial communities. Here, by applying theory to community four representative infant-gut associated Bifidobacterium species that employ varied strategies HMO consumption, we show arrival order sugar consumption phenotypes significantly affected formation. bifidum longum...
Faecalibacterium prausnitzii is a commensal gut bacterium that thought to provide protection against inflammatory diseases. However, this extremely oxygen sensitive, which limits its industrial application as probiotic. The use of prebiotics increase the abundance in an alternative strategy achieve possible health-promoting effect. We evaluated nine substances candidate for F. using pH-controlled single-batch fermenter human microbiota model. Of them, alginate markedly increased relative...
We previously investigated the gut microbiota of 453 healthy Japanese subjects aged 0 to 104 years and found that composition could be classified into some age-related clusters. In this study, we compared fecal metabolites between age-matched age-mismatched elderly examine roles in health elderly. Fecal 16 who fell an cluster (elderly-type group, E-GM) another (adult-type A-GM) were measured by CE-TOF-MS. A total eight significantly different groups: cholic acid taurocholic enriched A-GM...
Visceral fat accumulation is considered to be associated with a higher risk of chronic diseases. We investigated the effects Bifidobacterium longum subsp. (B. longum) BB536 and breve breve) MCC1274 on body composition, including visceral fat, in randomized, parallel-group, placebo-controlled study. Participants were between 29 64 years age had mass index (BMI) greater than 23 less 30. One hundred participants randomly assigned probiotics group or placebo group. administered probiotic...
Fortifying infant formula with human milk oligosaccharides, such as 2'-fucosyllactose (2'-FL), is a global trend. Previous studies have shown the inability of pathogenic gut microbes to utilize 2'-FL. However, present study demonstrates that type strain (JCM 1290T) Clostridium perfringens, pathobiont species often more prevalent and abundant in feces C-section-delivered infants, exhibits potentially growth on The expression genes for α-toxin, an activator NLRP3 inflammasome, ethanolamine...
Abstract This study aims to understand the mechanistic basis underlying response of Bifidobacterium lactulose ingestion in guts healthy Japanese subjects, with specific focus on a transporter. An vitro assay using mutant strains longum subsp. 105-A shows that solute-binding protein locus tag number BL105A_0502 (termed LT-SBP) is primarily involved uptake. By quantifying faecal abundance LT-SBP orthologues, which defined by phylogenetic analysis, we find subjects 10 7 9 copies genes per gram...
Examining how host cells affect metabolic behaviors of probiotics is pivotal to better understand the mechanisms underlying probiotic efficacy in vivo. However, studies elucidate interaction between and cells, such as intestinal epithelial remain limited. Therefore, this study, we performed a comprehensive metabolome analysis co-culture containing Bifidobacterium breve MCC1274 induced pluripotent stem (iPS)-derived small intestinal-like cells. In co-culture, observed significant increase...
Abstract Sharing of Bifidobacterium longum strains had recently been shown to occur among Japanese family members, a phenomenon that is not confined mother-infant pairs. In the current study, we investigated if bathtub water possible vehicle for exchange as consequence custom share by members during bathing practices. A total twenty-one subjects from five families, each consisting parents with either 2 or 3 children, were enrolled in this study and fecal microbiota all participants was...
Blautia is a genus of anaerobic bacteria that widely distributed in the mammalian gut. Recently, an increasing body research has demonstrated link between this and human health, suggesting applications as novel probiotic strain. Moreover, we have previously shown 2′-fucosyllactose (2′-FL), major component milk oligosaccharides, increases relative abundance sp., particularly wexlerae , cultured fecal microbiota healthy adults using pH-controlled single-batch fermenter. However, effects 2′-FL...
Journal Article New approach to use ethidium bromide monoazide as an analytical tool Get access J. Minami, Minami Morinaga Milk Industry, Higashihara, Zama, Kanagawa, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Yoshida, Yoshida T. Soejima, Soejima Takashi Biological Function Research Department, Food Science & Technology Institute, Industry Co., Ltd., 5‐1‐83, Kanagawa 228‐8583, Japan. E‐mail: t_soezim@morinagamilk.co.jp Yaeshima, Yaeshima Iwatsuki of...
Abstract Background The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the phenotype enhancing fibrinolysis. We hypothesized that soft tissue sarcoma (STS) affects expression of markers, which could be used to distinguish STS from benign tumors. analyzed correlations plasma levels D-dimer (DD), plasmin-α2 plasmin inhibitor complex (PIC), soluble fibrin (SF), thrombin-antithrombin III (TAT) elucidate whether these markers can...
Background: This study aimed to determine whether the prognostic nutritional index (PNI) can predict prognosis in patients with soft-tissue sarcoma (STS) before treatment and examine there is an association between PNI values clinical characteristics. Patients Methods: The data on 100 primary STS were retrospectively reviewed. cohort included 55 men 45 women, a mean age of 64 years. follow-up duration was 41.7 months. Results: median 51.35. significantly inversely associated tumor size,...
Ewing sarcoma is an aggressive and the second most common bone tumor in adolescent young adult patients. The 5-year survival rate 60-70% for localized disease but 30% patients with metastases. Here, we aimed to identify a therapeutic target evaluate antibody-based agents using vitro vivo models. We identified G protein-coupled receptor 64 (GPR64) as via next-generation RNA-sequencing. GPR64v205 mRNA was expressed HTB166, A673, MG63, 143B, HS-Sy II, HT1080 cell lines well sarcoma,...
Abstract Background Coagulation and fibrinolysis are distinct processes that highly correlated. Cells control coagulation by expression of tissue factor urokinase-type plasminogen activator receptor on their surface. Tumor cells express these proteins, adjust microenvironment induce tumor exacerbation. We hypothesized the plasma markers for in patients with soft sarcomas (STSs) was dependent level malignancy. To elucidate which predictive recurrence, metastasis prognosis, or fibrinolysis, we...
The authors propose a new non-destructive inspection method for underground fiberglass-reinforced plastic mortar (FRPM) pipelines. Their utilises time-domain responses of microwave guided-modes propagating along an FRPM pipe-wall. Through the analyses, they found that guided-mode signal pipe-wall is spread out to various waves corresponding straight and circumferential position unwanted foreign object on wall can be detected by examining path wave interrupted object. Additionally, also...
Oncocytoma is a benign tumor composed histologically of epithelial cells with abundant acidophilic, large granular cytoplasm packed accumulating mitochondria, and can be arranged in alveolar, tubular, or solid patterns. commonly found the kidneys, salivary glands, endocrine organs. arising retroperitoneal heterotopic adrenal tissue very rare. We report case oncocytoma that showed significantly high uptake F-18 fluorodeoxyglucose (F-18 FDG) on positron emission tomography (PET) study. The...
Aim: Bifidobacteria benefit host health and homeostasis by breaking down diet- host-derived carbohydrates to produce organic acids in the intestine. However, sugar utilization preference of bifidobacterial species is poorly understood. Thus, this study aimed investigate (i.e., glucose or lactose) various species. Methods: Strains belonging 40 species/subspecies were cultured on a modified MRS medium supplemented with and/or lactose, their preferential was assessed using high-performance...
We present an embedded SRAM cell in a 0.18 /spl mu/m CMOS technology for the first time. The memory size is 2.912 mu/m/sup 2/, which smaller than any SRAMs previously reported. fabrication process using Co-Salicide Direct-Strap fully compatible with salicide-CMOS high performance applications no need local interconnects or even contact-implants. In this process, sidewall spacer selectively etched at location connection before source-drain implants. To obtain borderless contact to diffusion,...