A5034280320- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Air Quality and Health Impacts
- Cardiovascular Health and Disease Prevention
- Trace Elements in Health
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Inflammatory mediators and NSAID effects
- Toxic Organic Pollutants Impact
- Selenium in Biological Systems
- Metal and Thin Film Mechanics
- Helicobacter pylori-related gastroenterology studies
- Cardiac electrophysiology and arrhythmias
- Carcinogens and Genotoxicity Assessment
- Cancer, Hypoxia, and Metabolism
- Hydrogen embrittlement and corrosion behaviors in metals
- Vector-borne infectious diseases
- Birth, Development, and Health
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Corrosion Behavior and Inhibition
- Adipose Tissue and Metabolism
Iwate University
2016-2025
Enoshima Aquarium
2025
National Institute of Advanced Industrial Science and Technology
2024
Panasonic (Japan)
1988-2023
Tohoku University
2011-2022
National Institute of Infectious Diseases
2009-2021
Hokkaido University
1985-2021
Saitama Medical University
2021
Life Science Institute
2019-2021
Osaka University
2001-2021
To examine the relationship between normal nocturnal decline in blood pressure and risk of cardiovascular mortality individuals with without high 24-h values.We obtained ambulatory readings from 1542 residents Ohasama, Japan, who were aged 40 years or more representative Japanese general population. We then followed up their survival for a mean 9.2 years. The was analysed using Cox proportional hazards model adjusted possible confounding factors.There linear mortality. On average, each 5%...
Most studies that have evaluated the association between body-mass index (BMI) and risks of death from any cause specific causes been conducted in populations European origin.We performed pooled analyses to evaluate BMI risk among more than 1.1 million persons recruited 19 cohorts Asia. The included approximately 120,700 deaths occurred during a mean follow-up period 9.2 years. Cox regression models were used adjust for confounding factors.In East Asians, including Chinese, Japanese,...
Objective To compare the predictive powers of self-measurement blood pressure at home (home measurement) and casual (screening) measurement for mortality. Design A prospective cohort study. Subjects methods We obtained screening measurements 1789 subjects aged ≥ 40 years who were followed up a mean 6.6 years. The prognostic significance mortality was determined by Cox proportional hazards regression model adjusted age, sex, smoking status, past history cardiovascular disease, use...
There is global concern over significant threats from a wide variety of environmental hazards to which children face. Large-scale and long-term birth cohort studies are needed for better management based on sound science. The primary objective the Japan Environment Children's Study (JECS), nation-wide study that started its recruitment in January 2011, elucidate factors affect children's health development.Approximately 100,000 expecting mothers who live designated areas will be recruited...
Abstract —To investigate the association between cardiovascular mortality and short-term variabilities in blood pressure heart rate, we performed a long-term prospective study of ambulatory monitoring Ohasama, Japan, starting 1987. We obtained rate 1542 subjects ≥40 years age. Blood were estimated as standard deviation measured every 30 minutes by monitoring. There 67 deaths during follow-up period (mean=8.5 years). The Cox proportional hazards model, adjusted for possible confounding...
The objective of this study was to elucidate the long-term prognostic significance ambulatory blood pressure. Ambulatory and casual pressure values were obtained from 1332 subjects (872 women 460 men) aged >or=40 years general population a rural Japanese community. Survival then followed for 14 370 patient analyzed by Cox hazard model adjusted possible confounding factors. There 72 cardiovascular deaths during 10.8-year follow-up. relationship between 24-hour systolic mortality risk U-shaped...
There is continuing controversy over whether the pattern of circadian blood pressure (BP) variation that includes a nocturnal decline in BP and morning pressor surge has prognostic significance for stroke risk. In this study, we followed incidence 1430 subjects aged ≥40 years Ohasama, Japan, an average 10.4 years. The association between risk was analyzed with Cox proportional hazards model after adjustment possible confounding factors. no significant total (percentage from diurnal level) or...
Day-by-day blood pressure and heart rate variability defined as within-subject SDs of home measurements can be calculated from long-term self-measurement. We investigated the prognostic value day-by-day in 2455 Ohasama, Japan, residents (baseline age: 35 to 96 years; 60.4% women). Home were measured once every morning for 26 days (median). A total 462 deaths occurred over a median 11.9 years, composing 168 cardiovascular (stroke: n=83; cardiac: n=85) 294 noncardiovascular deaths. Using Cox...
Background The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly Asia, as the prevalence overweight obesity; European-derived populations, obesity are established causes diabetes. shape association with risk its overall impact have not been adequately studied Asia. Methods Findings A pooled cross-sectional analysis was conducted to evaluate between baseline body mass index (BMI, measured weight kg divided by square height m) self-reported status...
目的：高齢者の社会的孤立をスクリーニングする尺度として国際的に広く使用されているLubben Social Network Scale短縮版（LSNS-6）の日本語版を作成し，信頼性および妥当性の検討を行った．方法：総合健診を受診した地域在住高齢者232名に面接式質問紙調査を行い，日本語版LSNS-6とともに，基本属性，主観的健康感，運動機能，既存のソーシャルサポート質問項目，日本語版Zung自己評価式抑うつ尺度（日本語版SDS），自殺念慮等に関するデータを得た．日本語版LSNS-6の内的一貫性についてはCronbach α係数，繰り返し再現性についてはSpearman相関係数，評価者間信頼性については級内相関係数を用いた．構成概念妥当性の検討には先行研究の結果との比較，併存妥当性の検討には日本語版SDSおよびソーシャルサポート質問項目との関連を検討した．結果：Cronbach...
Evidence for a link between long-term exposure to air pollution and lung cancer is limited Western populations. In this prospective cohort study, we examined association in Japanese population.The study comprised 63 520 participants living 6 areas 3 prefectures who were enrolled 1983 1985. Exposure particulate matter less than 2.5 µm aerodynamic diameter (PM(2.5)), sulfur dioxide (SO(2)), nitrogen (NO(2)) was assessed using data from monitoring stations located or nearby each area. The Cox...
To determine the optimum number of blood pressure self-measurements taken at home (home pressure) in relation to their predictive value for stroke risk.We obtained more than 14 measurements from 1491 people aged >or=40 years without a history general population Japan, and followed them up after mean period 10.6 years. The prognostic significance risk was examined using Cox proportional hazards regression model, which adjusted possible confounding factors.The increased progressively with...
To compare the prediction of mortality by ambulatory blood pressure monitoring and screening measurements in a general population.A prospective cohort study.We obtained data for 1542 subjects (565 men 977 women) aged > or = 40 years who were followed up to 8.1 (mean 5.1 years). Subjects subdivided into five groups according their levels. The prognostic significance was examined Cox proportional hazards regression model.The association between level more distinctive than it pressure. risk...
Although laboratory experiments and case-control studies have suggested that the consumption of green tea provides protection against gastric cancer, few prospective been performed.In January 1984, a total 26,311 residents in three municipalities Miyagi Prefecture, northern Japan (11,902 men 14,409 women 40 years age or older), completed self-administered questionnaire included questions about frequency tea. During 199,748 person-years follow-up, through December 1992, we identified 419...
Abstract —Although reference values for ambulatory blood pressure (ABP) monitoring have been investigated in several population studies, these were derived from cross-sectional observations and based merely on the statistical distribution of values. Therefore, we conducted a prospective cohort study to identify 24-hour ABP relation prognosis. We obtained measurements 1542 subjects (565 men) aged 40 years over general rural Japanese community then followed-up their survival status. There 117...
We performed a cross-sectional study in small town northern Japan to evaluate the distribution, reference values, and daily variation ambulatory blood pressure. A total of 705 subjects (229 men aged 61.3 +/- 13.4 years [mean SD] 476 women 57.5 13.3 years; 41.1% regional adult population, n = 1716), including those treated with antihypertensive drugs (n 231, 66.5 9.5 years) as well untreated 474, 55.0 13.5 years), participated study. Both screening pressures were measured 659 subjects....
Environmental exposure to some persistent organic pollutants has been reported be associated with a metabolic syndrome in the U.S. population.We evaluated associations of body burden levels dioxins and related compounds prevalence among general population Japan.We conducted cross-sectional study 1,374 participants not occupationally exposed these pollutants, living throughout Japan during 2002-2006. In fasting blood samples, we measured biochemical factors determined lipid-adjusted...
Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used terms "single necrosis" and "apoptosis" interchangeably. Increased research on mechanisms of death in recent years led understanding that apoptosis necrosis involve different cellular pathways these differences can important implications when considering overall toxicity, and, reasons, separate should be whenever differentiation is possible....
Background and Purpose— Ambulatory arterial stiffness index (AASI) pulse pressure (PP) are indexes of can be computed from 24-hour blood recordings. We investigated the prognostic value AASI PP in relation to fatal outcomes. Methods— In 1542 Ohasama residents (baseline age, 40 93 years; 63.4% women), we applied Cox regression relate mortality while adjusting for sex, BMI, MAP, smoking drinking habits, diabetes mellitus, a history cardiovascular disease. Results— During 13.3 years (median),...