A5064583205- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Pharmacology and Obesity Treatment
- Pancreatic function and diabetes
- Inflammatory Biomarkers in Disease Prognosis
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Diet and metabolism studies
- Thyroid Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Heart Rate Variability and Autonomic Control
- Blood properties and coagulation
- Folate and B Vitamins Research
- Growth Hormone and Insulin-like Growth Factors
- Advanced Glycation End Products research
- Cardiovascular Disease and Adiposity
Cardinal Tien Hospital
2013-2025
Fu Jen Catholic University
2016-2025
Taipei City Hospital
2024
Weatherford College
2022
Changhua Christian Hospital
2021
Nan Kai University of Technology
2011
Chi Mei Medical Center
2011
Tri-Service General Hospital
1995-2008
Tzu Chi University
2005-2007
Buddhist Tzu Chi General Hospital
2004-2007
An insulin-modified frequently sampled intravenous glucose tolerance test (FSIGTT) with minimal model analysis was compared the clamp in 11 subjects normal (NGT), 20 impaired (IGT), and 24 non-insulin-dependent diabetes mellitus (NIDDM). The insulin sensitivity index (SI) calculated from FSIGTT using 22- 12-sample protocols (SI(22) SI(12), respectively). Insulin expressed as SI(clamp) SIP(clamp). Minimal parameters were similar when SI(22) SI(12). SI could not be distinguished 0 ∼ 50% of...
To make large-scale association studies a reality, automated high-throughput methods for genotyping with single-nucleotide polymorphisms (SNPs) are needed. We describe PCR conditions that permit the use of TaqMan or 5′ nuclease allelic discrimination assay typing large numbers individuals any SNP and computational allow genotypes to be assigned automatically. demonstrate utility these methods, we typed >1600 G-to-T transversion results in glutamate-to-aspartate substitution at position...
Abstract Plasma glucose and insulin responses to a graded iv infusion of were compared in two groups glucose-tolerant women divided on the basis their sensitivity. Resistance insulin-mediated disposal was measured using suppression test, studied chosen represent highest lowest quartiles resistance seen normal population. The sensitivity pancreatic β-cell assessed by measuring glucose, insulin, C peptide concentrations response continuous infusions at rates 1, 2, 3, 4, 6, 8 mg/kg·min for 40...
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. In this study, we aimed to explore both primary effects single-locus and multilocus interactions test the hypothesis that type 2 diabetes (T2D) genes may contribute aetiology DN in T2D independently and/or through complex Taiwanese population with T2D.We genotyped six single nucleotide polymorphisms (SNPs) for five including adiponectin, C1Q collagen domain containing (ADIPOQ), ectonucleotide pyrophosphatase/...
Plasma glucose and insulin responses to a 75-g oral load, the steady-state plasma (SSPI) (SSPG) concentrations after an infusion of somatostatin, insulin, glucose, were determined 2 months delivery in 26 women; 13 who had normal pregnancy developed preeclampsia. The response was not different two groups, but significantly greater (P < .02) those been preeclamptic. Although mean (±SE) SSPI during study similar groups (51 ± v 56 µU/mL), SSPG higher preeclampsia (160 17 119 mg/dL). Thus, when...
Summary Objective The study aims to evaluate the efficacy of combination therapy with propylthiouracil (PTU) and cholestyramine in treatment Graves’ hyperthyroidism. Background Thyroxine (T4) is metabolized mainly liver by conjugation glucuronides sulphates that enter enterohepatic circulation. Thyrotoxic patients have an abnormal increase thyroid hormone their Previous studies on methimazole for hyperthyroidism shown it be effective adjunctive treatment. In this study, we examined PTU...
This study was designed to evaluate insulin sensitivity, proinflammatory markers and adiponectin concentration in young males with different subtypes of depressive disorder.Nonobese disorder (ages between 18 years 30 years; body mass index, BMI < or = 25 kg/m(2)) were recruited divided into reactive depression (RD, N 14), major (MD, 21) bipolar (BD, 15) based on clinical course symptom changes Hamilton rating scale for (HAM-D). Fourteen age- BMI-matched healthy enrolled as controls. All the...
Abstract Background Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect peroxisome proliferator-activated receptor-delta (PPARδ) agonists was shown previous studies. PPARδ also stimulate glucagon-like peptide-1 (GLP-1) secretion from human intestinal cells. Methods In this study, the individual synergic anti-inflammatory effects GLP-1 (exendin-4) (L-165,041) AGE-treated...
The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between single-nucleotide polymorphisms the aldosterone synthase gene and plasma glucose levels large population of Chinese Japanese origin. Two polymorphisms--one putative promoter (T-344C) another resulting lysine/arginine substitution at amino acid 173, which are complete linkage disequilibrium this population--were associated with...
With an estimated global frequency ranging from5 % to 21 %, polycystic ovary syndrome (PCOS) is one of the most prevalent hormonal disorders. There are many factors found be related PCOS. However, these researches used traditional methods such as multiple logistic regression (LR). Nowadays, machine learning (Mach-L) emerges a new method and can in medical researches. In present study, there were two goals: 1. Compare accuracy five alternative Mach-L techniques with that conventional LR. 2....
Type 2 diabetes mellitus is a significant health concern among elderly individuals in Taiwan, and liver dysfunction, particularly nonalcoholic fatty disease, prevalent this population. Gamma-glutamyl transferase (γ-GT), key enzyme involved glutathione metabolism, has been linked to metabolic disorders, including insulin resistance (IR) diabetes. However, its association with secretion phases (first-phase secretion, FPIS; second-phase SPIS) glucose effectiveness (GE) remains unclear. This...
Many studies showed that depression is correlated with osteoporosis, while others low cholesterol level also related to depression. However, these relationships still remain controversial. Since the bone mineral density (BMD) and hypocholesterolemia, there might exist a correlation between BMD plasma levels. To prove this, we enrolled 5000 individuals, 2170 males, 2830 females, who had health check-ups at private clinic 1998 1999. They were divided into three groups. Group 1 was composed of...
Recent studies indicate that obesity may play a key role in modulating genetic predispositions to type 2 diabetes (T2D). This study examines the main effects of both single-locus and multilocus interactions among variants Taiwanese obese nonobese individuals test hypothesis obesity-related genes contribute etiology T2D independently and/or through such complex interactions. We genotyped 11 single nucleotide polymorphisms for 10 candidate including adrenergic beta-2-receptor surface,...
Jiunn-Diann Lina, Dee Peib, Te-Lin Hsiab, Chung-Ze Wuc, Kun Wangb, Yen-Lin Changd, Chun-Hsin Hsud, Chene, Kwang-Wen Chenf & Sai-Hung Tang*ga Division of Endocrinology and Metabolism, Department Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, Republic Chinab Internal Cardinal Tien School, Fu Jen Catholic Xindian City, Chinac Shuang Ho Chinad Family Physicians, Chinae Pathology, Chinaf Saint Paul's Taoyuan, Chinag China