Yasser Riazalhosseini
A5064882820- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Evolution and Genetic Dynamics
- BRCA gene mutations in cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Radiomics and Machine Learning in Medical Imaging
- Microbial metabolism and enzyme function
- Lung Cancer Treatments and Mutations
- Mitochondrial Function and Pathology
McGill University
2016-2025
McGill Genome Centre
2020-2024
Victor (Japan)
2024
Centre For Human Genetics
2024
McGill University and Génome Québec Innovation Centre
2012-2023
Concordia University
2017-2023
German Cancer Research Center
2006-2014
Institute of Human Genetics
2014
Heidelberg University
2006-2014
Heidelberg University
2011
Abstract Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most aggressive subtype. Here we identify hypoxia-induced ECM re-modeler, lysyl oxidase (LOX) as key inducer of chemoresistance by developing chemoresistant TNBC tumors vivo and characterizing their transcriptomes RNA-sequencing. Inhibiting LOX reduces collagen cross-linking fibronectin assembly, increases drug penetration, downregulates ITGA5/FN1 expression, resulting inhibition FAK/Src signaling,...
Abstract Estrogen receptor α (ERα) upregulation causes abnormal cell proliferation in about two thirds of breast cancers, yet understanding the underlying mechanisms remains incomplete. Here, we show that high expression microRNA miR-375 ERα-positive lines is a key driver their proliferation. overexpression was caused by loss epigenetic marks including H3K9me2 and local DNA hypomethylation, dissociation transcriptional repressor CTCF from promoter, interactions ERα with regulatory regions...
Abstract Purpose: Relapsed or refractory diffuse large B-cell lymphoma (rrDLBCL) is fatal in 90% of patients, and yet little known about its biology. Experimental Design: Using exome sequencing, we characterized the mutation profiles 38 rrDLBCL biopsies obtained at time progression after immunochemotherapy. To identify genes that may be associated with relapse, compared frequency samples relapse to an unrelated cohort 138 diagnostic DLBCLs separately amplified specific mutations their...
Breast cancer is a heterogenous disease with variability in tumor cells and the surrounding microenvironment (TME). Understanding molecular diversity breast critical for improving prediction of therapeutic response prognostication. High-plex spatial profiling tumors enables characterization heterogeneity TME, which can holistically illuminate biology growth, dissemination and, ultimately, to therapy. The GeoMx Digital Spatial Profiler (DSP) researchers spatially resolve quantify proteins RNA...
Abstract Vascular anomalies, including local and peripheral thrombosis, are a hallmark of glioblastoma (GBM) an aftermath deregulation the cancer cell genome epigenome. Although molecular effectors these changes poorly understood, upregulation podoplanin (PDPN) by cells has recently been linked to increased risk for venous thromboembolism (VTE) in GBM patients. Therefore, regulation this platelet-activating protein transforming events is considerable interest. We used single-cell bulk...
Abstract Targeting neovascularization in glioblastoma (GBM) is hampered by poor understanding of the underlying mechanisms and unclear linkages to tumour molecular landscapes. Here we report that different subtypes human glioma stem cells (GSC) trigger distinct endothelial responses involving either angiogenic or circumferential vascular growth (vasectasia). The latter process selectively triggered mesenchymal (but not proneural) GSCs mediated a subset extracellular vesicles (EVs) able...
Breast carcinoma (BC) has been extensively profiled by high-throughput technologies for over a decade, and broadly speaking, these studies can be grouped into those that seek to identify patient subtypes (studies of heterogeneity) or gene signatures with prognostic predictive capacity. The sheer number reported led speculation everything is in BC. Here, we show this ubiquity an apparition caused poor understanding the interrelatedness between subtype molecular determinants prognosis. Our...
Widespread remodeling of the transcriptome is a signature cancer; however, little known about post-transcriptional regulatory factors, including RNA-binding proteins (RBPs) that regulate mRNA stability, and extent to which RBPs contribute cancer-associated pathways. Here, by modeling global change in gene expression based on effect sequence-specific we show RBP-mediated stability programs are recurrently deregulated cancerous tissues. Particularly, uncovered several abnormal renal cell...
Papillary renal cell carcinomas (pRCC) are classically divided into type 1 and 2 tumors. However, many cases do not fulfill all the criteria for either type. We describe clinical, morphologic, immunohistochemical (IHC) features of 132 pRCCs to better characterize frequency nature tumors with overlapping features. Cases were reviewed classified; IHC evaluation CK7, EMA, TopoIIα, napsin A, AMACR was performed on 95 cases. The frequencies 1, 2, "overlapping" pRCC 25%, 28%, 47%, respectively....
Abstract Recent genomic studies of sporadic clear cell renal carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men women (male:female ratio approaches 2:1), we compared genome-wide distribution chromosomal abnormalities in both sexes. We observed a higher frequency for somatic recurrent copy number variations (CNVs) autosomes male subjects, whereas loss chromosome X was detected exclusively female patients (17.1%). Furthermore, Y (LOY)...
Anaplastic oligodendroglioma (AO) are rare primary brain tumours that generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC FUBP1. We also identified recurrent TCF12 additional series of 83 AO. Overall, 7.5% mutated for TCF12, which encodes oligodendrocyte-related...
Abstract Purpose: Tamoxifen remains an important hormonal therapy for ER-positive breast cancer; however, development of resistance is a major obstacle in clinics. Here, we aimed to identify novel mechanisms tamoxifen and provide actionable drug targets overcoming resistance. Experimental Design: Whole-transcriptome sequencing, downstream pathway analysis, repositioning approaches were used modulators [here: phosphodiesterase 4D (PDE4D)] Clinical data involving tamoxifen-treated patients...
Abstract Purpose: Patients with resected localized clear-cell renal cell carcinoma (ccRCC) remain at variable risk of recurrence. Incorporation biomarkers may refine prediction and inform adjuvant treatment decisions. We explored the role tumor genomics in this setting, leveraging largest cohort to date ccRCC tissues subjected targeted gene sequencing. Experimental Design: The somatic mutation status 12 genes was determined 943 cases from a multinational patients, associations outcomes were...
Hereditary hearing loss (HHL) is a very common disorder. When inherited in an autosomal recessive manner, it typically presents as isolated finding. Interestingly and unexpectedly, spite of extreme heterogeneity, mutations one gene, GJB2, are the most cause congenital severe-to-profound deafness many different populations. In this study, we assessed contributions made by GJB2 chromosome 13 g.1777179_2085947del (the deletion more commonly known del (GJB6-D13S1830) that includes portion GJB6...
Abstract Lung cancer is the most frequent cause of death worldwide. It affects more men than women, and generally have worse survival outcomes. We compared gene co-expression networks in affected unaffected lung tissue from 126 consecutive patients with Stage IA–IV undergoing surgery curative intent. observed marked degradation a sex-associated transcription network tumour tissue. This disturbance, detected 27.7% male tumours discovery dataset 27.3% further 123-sample replication dataset,...
Acinar-to-ductal metaplasia (ADM) is a recently recognized, yet less well-studied, precursor lesion of pancreatic ductal adenocarcinoma (PDAC) developed in the setting chronic pancreatitis. Through digital spatial mRNA profiling, we compared ADM and adjacent PDAC tissues from patient samples to unveil bridging genes during malignant transformation By comparing with 7-methylguanosine (m7G)-seq dataset, screened 19 m7G methylation for subsequent large sample analysis. We constructed "m7G...
Measuring mRNA decay in tumours is a prohibitive challenge, limiting our ability to map the post-transcriptional programs of cancer. Here, using statistical framework decouple transcriptional and effects RNA-seq data, we uncover stability changes that accompany tumour development progression. Analysis 7760 samples across 18 cancer types suggests are ~30% as frequent events, highlighting their widespread role shaping transcriptome. Dysregulation associated with >80 RNA-binding proteins (RBPs)...