Weiyin Zhou
A5067361490- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Hematopoietic Stem Cell Transplantation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- BRCA gene mutations in cancer
- Cancer-related gene regulation
- T-cell and B-cell Immunology
- Genital Health and Disease
- Prenatal Screening and Diagnostics
- Chromosomal and Genetic Variations
Division of Cancer Epidemiology and Genetics
2016-2025
Frederick National Laboratory for Cancer Research
2016-2025
National Cancer Institute
2016-2025
National Institutes of Health
2010-2025
Cancer Genetics (United States)
2015-2025
Leidos (United States)
2015-2024
Leidos Biomedical Research Inc. (United States)
2015-2024
Cancer Institute (WIA)
2021-2023
United States Department of Health and Human Services
2014-2022
Center for Cancer Research
2012-2020
Background Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and has a high risk distant metastasis at every disease stage. We aimed to characterize genomic landscape LUAD identify mutation signatures associated with tumor progression. Methods Findings performed an integrative analysis, incorporating whole exome sequencing (WES), determination DNA copy number methylation, transcriptome for 101 samples from Environment And Genetics in Etiology (EAGLE) study....
Docosahexaenoic acid (DHA; 22:6n-3) is a critical constituent of the brain, but its metabolism has not been measured in human brain vivo. In monkeys, using positron emission tomography (PET), we first showed that intravenously injected [1-(11)C]DHA mostly entered nonbrain organs, with approximately 0.5% entering brain. Then, PET and intravenous 14 healthy adult humans, quantitatively imaged regional rates incorporation (K*) DHA. We also cerebral blood flow (rCBF) [(15)O]water. Values K* for...
Mosaic loss of the Y chromosome (mLOY) is most commonly reported large structural somatic event. Previous studies have indicated age and cigarette smoking increase risk mLOY, but relationship other exposures with mLOY disease has not been adequately investigated. We characterized in a cohort 223,338 men from UK Biobank by scanning for deviations genotyping array median log2 intensity ratios (mLRR) using standard algorithm. A total 3,789 (1.7%) showed evidence (mLRR < -0.15). In...
Abstract To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here show rates for X-chromosome are four times higher than mean autosomal rates; more often include entire participants with likely harbour events. frequency increases age (0.11% 50-year olds; 0.45% 75-year olds), as...
Genomics of radiation-induced damage The potential adverse effects exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, well long-term sequelae increased risk cancer. There have been a few studies examining transgenerational risks exposure but the results inconclusive. Morton et al. analyzed papillary thyroid tumors, normal tissue, and blood hundreds survivors Chernobyl accident compared them against those unexposed patients. findings...
Chordoma is a rare bone tumor with an unknown etiology and high recurrence rate. Here we conduct whole genome sequencing of 80 skull-base chordomas identify PBRM1, SWI/SNF (SWItch/Sucrose Non-Fermentable) complex subunit gene, as significantly mutated driver gene. Genomic alterations in PBRM1 (12.5%) homozygous deletions the CDKN2A/2B locus are most prevalent events. The combination chromosome 22q deletion, which involves another gene (SMARCB1), shows strong associations poor...
Abstract Purpose: Cervical cancer is one of the most common causes mortality for women living in poverty, causing more than 28,000 deaths annually Latin America and 266,000 worldwide. To better understand molecular basis disease, we ascertained blood tumor samples from Guatemala Venezuela performed genomic characterization. Experimental Design: We human papillomavirus (HPV) typing identified somatically mutated genes using exome ultra-deep targeted sequencing with confirmation Mexico. Copy...
Background Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterised by erythroid hypoplasia. It associated with congenital anomalies and a high risk of developing specific cancers. DBA caused predominantly autosomal dominant pathogenic variants in at least 15 genes affecting ribosomal biogenesis function. Two X-linked recessive have been identified. Objectives We aim to identify the genetic aetiology DBA. Methods Of 87 families enrolled institutional...
Mosaic loss of the Y chromosome (mLOY) in peripheral leukocytes is a somatic event which fraction have lost entire chromosome. The frequency mLOY increases with age and may reflect poor genomic maintenance as well clonal imbalances normal immune function, making an attractive candidate marker for cancer risk. Here, we investigated relationship between incident large sample 207,603 cancer-free men from UK Biobank, 13,895 developed solid tumor during follow-up. We identified by scanning...
Abstract Ewing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1 - FLI1 fusion. We performed genome-wide association study of 733 EWS cases and 1346 unaffected individuals European ancestry. Our replicates previously reported susceptibility loci at 1p36.22, 10q21.3 15q15.1, identifies new 6p25.1, 20p11.22 20p11.23. Effect estimates exhibit odds ratios in excess 1.7, which high for GWAS, striking light rarity familial syndromes. Expression quantitative trait locus (eQTL) analyses...
Biomarkers have gained an increased importance in the past years helping physicians to diagnose Alzheimer's disease (AD). This study was designed identify a blood-based, transcriptomic signature that can differentiate AD patients from control subjects. The performance of then evaluated for robustness independent blinded sample population. RNA extracted 177 blood samples (90 and 87 controls) gene expression profiles were generated using human Genome-Wide Splice Array™. These used establish...
The XAF1 -E134* variant increases the cancer risk for carriers of TP53 -R337H allele.
Abstract Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number alteration in leukocytes men. In this study, we investigate blood cell counts as a potential mechanism linking mLOY to disease risk 206,353 UK males. Associations between mLOY, by genotyping arrays, and were assessed multivariable linear models adjusted for relevant factors. Among participants, was 39,809 We observed associations reduced erythrocyte count (−0.009 [−0.014, −0.005] × 10 12 cells/L,...
G protein-coupled receptors (GPCRs) are the largest signaling family in genome, serve an expansive array of functions, and targets for ≈50% current therapeutics. In many tissues, such as airway smooth muscle (ASM), complex, unexpected, or paradoxical responses to agonists/antagonists occur without known mechanisms. We hypothesized that ASM express more GPCRs than predicted, these undergo substantial alternative splicing, creating a highly diversified receptor milieu. Transcript arrays were...
Large population studies show that polyunsaturated fatty acids are important for human health, but determining relationships between the health benefits and acid content has been hampered by unavailability of labor-effective high-throughput technologies. An automated high throughput analysis was developed from a previous procedure based on direct transesterification including automation chemical procedures, data acquisition automatic processing. The method validated applied to umbilical cord...