A5061663138- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Human Health and Disease
- Advances in Oncology and Radiotherapy
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Radioactive contamination and transfer
- Lymphoma Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Multiple and Secondary Primary Cancers
- Telomeres, Telomerase, and Senescence
- Cancer-related Molecular Pathways
- Radioactivity and Radon Measurements
- Oral Health Pathology and Treatment
- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Healthcare Systems and Public Health
- Ukraine: War, Education, Health
- Acute Myeloid Leukemia Research
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Education and Social Development in Ukraine
- Air Quality and Health Impacts
- Glutathione Transferases and Polymorphisms
- Biomarkers in Disease Mechanisms
National Academy of Medical Sciences of Ukraine
2015-2024
Candid
2023
Kyiv City Clinical Oncology Center
2021-2023
ORCID
2023
National Academy of Medical Sciences
2015-2022
National Cancer Institute
2020
Division of Cancer Epidemiology and Genetics
2020
Duke Medical Center
2010
Academy of Medical Sciences
1996
Background We examined the human toll and subsequent humanitarian crisis resulting from Russian invasion of Ukraine, which began on 24 February 2022. Method extracted analysed data military attacks Ukrainians between 4 August The tracked direct deaths injuries, damage to healthcare infrastructure impact health, destruction residences, infrastructure, communication systems, utility services – all disrupted lives Ukrainians. Results As 2022, 5552 civilians were killed outright 8513 injured in...
Risks of most types leukemia from exposure to acute high doses ionizing radiation are well known, but risks associated with protracted exposures, as associations between and chronic lymphocytic (CLL), not clear.
Genomics of radiation-induced damage The potential adverse effects exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, well long-term sequelae increased risk cancer. There have been a few studies examining transgenerational risks exposure but the results inconclusive. Morton et al. analyzed papillary thyroid tumors, normal tissue, and blood hundreds survivors Chernobyl accident compared them against those unexposed patients. findings...
Romanenko, A. Ye., Finch, S. C., Hatch, M., Lubin, J. H., Bebeshko, V. G., Bazyka, D. A., Gudzenko, N., Dyagil, I. S., Reiss, R. F., Bouville, Chumak, V., Trotsiuk, N. K., Babkina, Belyayev, Yu., Masnyk, I., Ron, E., Howe, G.;thR. and Zablotska, L. B. The Ukrainian-American Study of Leukemia Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks. Radiat. Res. 170, 711–720 (2008).Leukemia is one the cancers most susceptible to induction by ionizing radiation, but...
The last decades have seen increased concern about the possible effects of low to moderate doses ionizing radiation (IR) exposure on cognitive function. An interdisciplinary group experts (biologists, epidemiologists, dosimetrists and clinicians) in this field gathered together framework European MELODI workshop non-cancer IR summarise state knowledge topic elaborate research recommendations for future studies area. Overall, there is evidence from both biology epidemiology, though a better...
In a nuclear or radiological event, an early diagnostic prognostic tool is needed to distinguish unexposed from low- and highly exposed individuals with the latter requiring intensive medical care. Radiation-induced gene expression (GE) changes observed within hours days after irradiation have shown potential serve as biomarkers for either dose reconstruction (retrospective dosimetry) prediction of consecutively occurring acute chronic health effects. The advantage GE markers lies in their...
Romanenko, A., Bebeshko, V., Hatch, M., Bazyka, D., Finch, S., Dyagil, I., Reiss, R., Chumak, Bouville, Gudzenko, N., Zablotska, L., Pilinskaya, Lyubarets, T., Bakhanova, E., Babkina, Trotsiuk, Ledoschuk, B., Belayev, Y., Dybsky, S. Ron, E. and Howe, G. The Ukrainian-American Study of Leukemia Related Disorders among Chornobyl Cleanup Workers from Ukraine: I. Methods. Radiat. Res. 170, 691–697 (2008).There are relatively few data on the risk leukemia those exposed to external radiation...
Abstract This article summarizes the results of 30 y follow-up cancer and noncancer effects in Ukrainian cleanup workers after Chornobyl accident. The number power plant employees first responders with acute radiation syndrome under by National Research Center for Radiation Medicine decreased from 179 1986–1991 to 105 2011–2015. Cancers leukemia (19) cardiovascular diseases (21) were main causes deaths among survivors (54) during postaccident period. Increased risks cohort 110,645 exposed...
Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research date has confined studies disease phenotypes in groups exposed high doses and dose rates, such as the Japanese atomic bomb survivors. Transgenerational parental irradiation can be addressed using powerful new genomic technologies. In collaboration with Ukrainian National Research Center for Radiation Medicine, US Cancer Institute, 2014-2018, initiated alterations study among children...
Objective - to estimate the possible effects of low dose ionizing radiation on human cognitive function in adult hood and utero.Cognitive tests, telomere length expression genes regulating were studied Chornobyl cleanup workers who exposed doses under 500 mSv (n = 326) subjects utero during first days after accident Prypiat town 104). The neurocognitive assessment covered mem ory, attention, language, executive visiospatial functions. In young adults prenatal exposure a relation ship was...
This paper describes dose reconstruction for a joint Ukrainian-American case-control study of leukemia that was conducted in cohort 110,645 male Ukrainian cleanup workers the Chornobyl (Chernobyl) accident who were exposed to various radiation doses over 1986–1990 time period. Individual bone-marrow due external irradiation along with respective uncertainty distributions calculated 1,000 subjects using RADRUE method, which employed personal history data collected course an interview subject...
Radiation doses of parents exposed from the Chornobyl accident as cleanup workers or evacuees were estimated in National Cancer Institute-National Research Center for Medicine trio (i.e. father, mother, offspring) study aimed at investigating radiation effects on germlinede novomutations children well other outcomes. Paternal (testes) and maternal (ovaries) gonadal calculated along with associated uncertainty distributions following exposure pathways: (a) external irradiation during mission,...
Chronic lymphocytic leukemia (CLL) was the predominant in a recent study of Chornobyl cleanup workers from Ukraine exposed to radiation (UR-CLL). Radiation risks CLL significantly increased with increasing bone marrow doses. Current analysis aimed clarify whether were due or genetic mutations Ukrainian population. A detailed characterization genomic landscape performed unique sample 16 UR-CLL patients and age- sex-matched unexposed general population Ukrainian-CLL (UN-CLL) Western-CLL...
Ionizing radiation is a well-known carcinogen. Chromosome aberrations, and in particular micronuclei represent an early biological predictor of cancer risk. There are well-documented associations with ionizing dose some radiation-exposed groups, although not all. That seen all groups may be because cells will generally pass through mitosis, so that radiation-induced decay, within few years after exposure. Buccal samples from group 111 male workers Ukraine exposed to during the cleanup...
An overview and new data are presented from cancer studies of the most exposed groups population after Chornobyl accident, performed at National Research Center for Radiation Medicine (NRCRM). Incidence rates solid cancers were analyzed 1990–2016 period in cleanup workers, evacuees, general contaminated areas. In male significant increase was demonstrated total, leukemia, lymphoma, thyroid cancer, as well breast increased females. Significantly elevated incidence identified workers cohort...