A5028027928- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Infection Control in Healthcare
- Complement system in diseases
- Carcinogens and Genotoxicity Assessment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Medical Device Sterilization and Disinfection
- Hemoglobinopathies and Related Disorders
- T-cell and Retrovirus Studies
- Sarcoma Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Parathyroid Disorders and Treatments
Kyoto Medical Center
2023-2025
Cleveland Clinic
2021-2024
Hiroshima University Hospital
2019-2024
Kyoto University
2010-2023
IRCCS Policlinico San Donato
2023
Gifu University
2015-2022
Hiroshima University
1988-2018
Kokura Memorial Hospital
2012-2015
Gifu University Hospital
2014
Kobe City Medical Center General Hospital
2006-2013
Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 cytoplasmic ADH5, have greatly shortened lifespans develop leukemia. Hematopoiesis is disrupted profoundly, with a reduction hematopoietic stem cells common lymphoid progenitors causing severely depleted acquired immune system. show formaldehyde substrate ADH5 establish methods to quantify elevated blood...
Genomic mutations drive the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia. While morphological clinical features have dominated classical criteria for diagnosis classification, incorporation molecular data can illuminate functional pathobiology. Here we show that unsupervised machine learning identify objective clusters, irrespective anamnestic clinico-morphological features, despite complexity alterations in neoplasia. Our approach reflects disease evolution, informed...
Abstract Background TP53 mutations ( MT ) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival cancer. Lesions affecting only one allele might not be directly leukemogenic, questioning the presence of cryptic subclones cases dismal prognosis. Methods We have collected clinical and molecular data 7400 patients myeloid neoplasms applied a novel model by identifying an optimal VAF cutoff using statistically robust strategy...
Abstract PHF6 mutations ( MT ) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of MN. Here we show three main findings our comprehensive genomic proteomic study. Firstly, a different pattern genes correlating with male female cases. When analyzing cases separately, only cases, RUNX1 U2AF1 co-mutated . In contrast, reveal co-occurrence ASXL1 X-chromosome deletions Next, proteomics analysis reveals direct interaction...
Bacillus cereus is a growing concern as cause of life-threatening infections in patients with hematologic malignancies. However, the risk factors for unfavorable outcomes have not been fully elucidated. At our institution, we observed growth B. blood culture 68 (23) or without (45) malignancies treated from September 2002 to November 2009. We defined case having sepsis when more than two sets were positive only single set was absence other microorganisms who had definite infectious lesions....
Fanconi anemia is a rare recessive disease characterized by multiple congenital abnormalities, progressive bone marrow failure, and predisposition to malignancies. It results from mutations in one of the 22 known FANC genes. The number Japanese patients with defined genetic diagnosis was relatively limited. In this study, we reveal subtyping characteristics mutated genes Japan clarify genotype-phenotype correlations. We studied 117 successfully subtyped 97% cases. FANCA FANCG pathogenic...
A 79-year-old woman was admitted to our hospital with a persistent fever, malaise, and anemia requiring frequent transfusions. peripheral blood smear revealed erythrocyte agglutination high titer of cold agglutinins. Imaging examination pulmonary emboli multiple subacute cerebral infarctions. Despite the absence lymphadenopathy or splenomegaly, diagnosis intravascular large B-cell lymphoma (IVLBCL) confirmed through random skin biopsies. Immunochemotherapy successfully induced remission her...
A 55-year-old woman was diagnosed with POEMS syndrome; however, we could not perform high-dose chemotherapy autologous peripheral blood stem cell transplantation (auto-PBSCT) because of rapidly progressive congestive heart failure. Thus, treated the patient thalidomide plus dexamethasone, which brought about a marked improvement systolic dysfunction, syndrome-related symptoms and serum concentrations vascular endothelial growth factor. Subsequently, safely performed auto-PBCST. This report...
The V-domain Ig suppressor of T-cell activation (VISTA) has been recognized as a critical negative regulator antitumor immune response and is gaining growing interest potential pharmacological target in immunotherapy. This molecule highly expressed hematopoietic stem cells myeloid compartment, it found upmodulated acute leukemia (AML). However, VISTA-associated features are relatively unexplored malignancies. Herein, we aimed to explore whether this checkpoint could play role the generation...
Abstract Complete or partial deletions of chromosome 7 (-7/del7q) belong to the most frequent chromosomal abnormalities in myeloid neoplasm (MN) and are associated with a poor prognosis. The disease biology -7/del7q genes responsible for leukemogenic properties have not been completely elucidated. Chromosomal may create clonal vulnerabilities due haploinsufficient (HI) contained deleted regions. Therefore, HI potential targets synthetic lethal strategies. Through comprehensive multimodal...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with poor prognosis. We encountered unique case of BPDCN that was leukemic at presentation without skin lesion and expressed CD33 antigen. A 74-year-old man admitted because dyspnea. Physically, hepatosplenomegaly, but not lesions superficial lymph node swelling, noted. The white blood count 33.6 × 10(9)/L 19% giant abnormal cells. These cells were positive for CD4, CD86, CD123 (bright), BDCA-2, HLA-DR,...