A5009774551- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Complement system in diseases
- RNA Research and Splicing
- Immunodeficiency and Autoimmune Disorders
- Electrospun Nanofibers in Biomedical Applications
- Platelet Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Blood disorders and treatments
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Angiogenesis and VEGF in Cancer
- Blood groups and transfusion
Roswell Park Comprehensive Cancer Center
2021-2024
Jagiellonian University
2023
Cleveland Clinic
2017-2022
Queen's University
2022
Islamic University of Lebanon
2022
Cornell University
2019
Cerner (United States)
2019
Cleveland Clinic Lerner College of Medicine
2018
University of Pittsburgh
2014-2017
McGowan Institute for Regenerative Medicine
2014-2017
Abstract Myelodysplastic syndromes (MDS) arise in older adults through stepwise acquisitions of multiple somatic mutations. Here, analyzing 1809 MDS patients, we infer clonal architecture by using a stringent, the single-cell sequencing validated PyClone bioanalytic pipeline, and assess position mutations within architecture. All 3,971 are grouped based on their rank deduced hierarchy (dominant secondary). We evaluated how they affect resultant morphology, progression, survival response to...
Genomic mutations drive the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia. While morphological clinical features have dominated classical criteria for diagnosis classification, incorporation molecular data can illuminate functional pathobiology. Here we show that unsupervised machine learning identify objective clusters, irrespective anamnestic clinico-morphological features, despite complexity alterations in neoplasia. Our approach reflects disease evolution, informed...
Abstract Therapy-related myeloid neoplasms (tMN) are complications of cytotoxic therapies. Risk tMN is high in recipients autologous hematopoietic stem cell transplantation (aHSCT). Acquisition genomic mutations represents a key pathogenic driver but the origins, timing and dynamics, particularly context preexisting or emergent clonal hematopoiesis (CH), have not been sufficiently clarified. We studied cohort 1507 patients undergoing aHSCT 263 who developed without to determine...
Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment ischemic diseases and might be more therapeutically effective to reestablish vasculature than provision a single GF. Vascular endothelial factor (VEGF) hepatocyte (HGF) are two potent angiogenic factors. However, due rapid degradation dilution in body, their will rely on an mode delivery. A coacervate, composed heparin biodegradable polycation, which protects GFs from proteolysis potentiates...
Somatic TET2 mutations (TET2MT) are frequent in myeloid neoplasia (MN), particularly chronic myelomonocytic leukemia (CMML). TET2MT includes mostly loss-of-function/hypomorphic hits. Impaired activity skews differentiation of hematopoietic stem cells toward proliferating precursors. This study was prompted by the observation biallelic gene inactivations (biTET2i ) CMML. We speculated that biTET2i might be associated with distinct clinicohematological features. analyzed 1045 patients MN. Of...
A biodegradable and injectable hydrogel was designed using dual physical dynamic bonds based on host-guest chemistry electrostatic interactions to build up the network structure. The material synthesized by simultaneously coupling mono-carboxylic acid terminated poly(ethylene glycol) arginine aspartate diglyceride) yield a mPEG-grafted argininylaspartate (mPEG-g-PEAD). When mixing this polymer with α-cyclodextrin natural polyanion (heparin), supramolecular formed in quick gelation shear...
Transplanted stem/progenitor cells improve tissue healing and regeneration anatomically functionally, mostly due to their secreted trophic factors. However, harsh conditions at the site of injury, including hypoxia, oxidative inflammatory stress, increased fibrosis insufficient angiogenesis, in some cases immunological response or incompatibility, are detrimental stem cell survival. To overcome complexity deficiencies therapy, coacervate delivery platform is deemed promising because it...
Abstract Background Osteoarthritis and cartilage injury treatment is an unmet clinical need. Therefore, development of new approaches to treat these diseases critically needed. Previous work in our laboratory has shown that murine muscle-derived stem cells (MDSCs) can efficiently repair articular osteochondral osteoarthritis model. However, the capacity human not been studied which prompt this study. Method In study, we tested vitro chondrogenesis ability six populations (hMDSCs), before...