A5050080702- Rare-earth and actinide compounds
- Shape Memory Alloy Transformations
- Magnetic Properties of Alloys
- Nuclear Physics and Applications
- Inorganic Chemistry and Materials
- Metal and Thin Film Mechanics
- Magnetic properties of thin films
- Magnetic and transport properties of perovskites and related materials
- Circadian rhythm and melatonin
- Advanced Condensed Matter Physics
- Creativity in Education and Neuroscience
- Spaceflight effects on biology
- Pharmacogenetics and Drug Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Disorders and Treatments
- Heusler alloys: electronic and magnetic properties
- Metallurgical and Alloy Processes
- Non-Destructive Testing Techniques
- Microstructure and Mechanical Properties of Steels
- Force Microscopy Techniques and Applications
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- PI3K/AKT/mTOR signaling in cancer
- High-pressure geophysics and materials
- Renal Diseases and Glomerulopathies
Eisai (Japan)
2011-2025
Ritsumeikan University
2004-2025
Mie University
2001-2018
National Hospital Organization Kyushu Cancer Center
2014-2017
Ryukoku University
1998-2012
Waseda University
2009-2012
The University of Tokyo
1991-2010
Advanced Research Institute
2009
Doshisha University
2008
Fujita Health University
2005-2006
To evaluate whether mutations in the human multidrug resistance (MDR)-1 gene correlate with placental P-glycoprotein (PGP) expression, we sequenced MDR-1 cDNA and measured PGP expression by Western blotting 100 placentas obtained from Japanese women. Nine single nucleotide polymorphisms (SNPs) were observed an allelic frequency of 0.005 to 0.420. Of these SNPs, G2677A (allelic = 0.18) G2677T (0.39) exon 21 associated amino acid conversion Ala Thr Ser, respectively. Sixty-one 65 samples...
Twenty-four hour patterns of plasma corticosterone levels and food intake were determined at 3-4 h intervals weekly for 7 consecutive weeks in blinded intact female adult rats exposed to continuous illumination. Plasma samples obtained from the tail vein. Resting circadian periodicity by this method essentially similar those decapitation. Circadian adrenocortical activity shifted both rats. In each group, shift these two activities similar. Between groups, however, markedly different. under...
Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and being developed as an anticancer drug. P450s are involved in one of the elimination pathways lenvatinib, mono-oxidized metabolites, such <i>N</i>-oxide (M3) desmethylated metabolite (M2), form rats, dogs, monkeys, humans. Meanwhile, two other oxidative metabolites produced only monkey human liver S9 fractions, their structures have been identified using high-resolution mass...
Abstract Aim: The purpose of our study was to investigate the association between low maternal prepregnancy body mass index (BMI) less than 18.5 kg/m 2 and incidence small for gestational age (SGA) infants. Material & Methods: This a cross‐sectional study. women with BMI 25.0 who gave birth single term infants (37–42 weeks) at clinics hospitals in Tokyo metropolitan area 2003 2004 were analyzed risk factors SGA. Results: Five hundred seventy‐two underweight (BMI < ) 2708 (75.1%)...
Lenvatinib, a potent inhibitor of multiple tyrosine kinases, including vascular endothelial growth factor receptors 2 and 3, generated unique metabolites after oral administration [<sup>14</sup>C]lenvatinib (30 mg/kg) to male cynomolgus monkey. Lenvatinib was found be transformed GSH conjugate, through displacement an <i>O</i>-aryl moiety, at the quinoline part molecule in liver kidneys. The conjugate underwent further hydrolysis by γ-glutamyltranspeptidase dipeptidases, followed...
The effect of extracellular ATP on adipogenesis was investigated using the mouse 3T3-L1 cell line. Incubation cells with (1–100 μM) for 5 min induced actin filament reorganization and membrane ruffling mediated through P2Y receptors. Enhancement preadipocyte migration into fat clusters is one essential processes adipose tissue development in vivo assays revealed that stimulation receptors enhanced chemokinesis (migration) a concentration dependent manner. In this line, growth arrest required...
The pharmacokinetic characteristics of testosterone propionate were studied in normal men after a single im dose 25 mg propionate-19,i9,19-d3; Plasma levels propionate-19,19,19-d3, its active metabolite testosterone-i9,19,19-d3, and endogenous measured by gas chromatography-mass spectrometry. Testosterone propionate-19,19,l9-d3 was gradually transferred from the injection site to systemic circulation. plasma propionate-19,l9,19-d3 maintained at 2–4 ng/ ml between 3 36 h administration....
Trapping reagents are powerful tools to detect unstable reactive metabolites. There a variety of trapping based on chemical reactivity electrophiles, and we investigated the thiol amine metabolically generated electrophiles commercially available electrophilic compounds. Glutathione (GSH) N-acetylcysteine (Nac) trapped soft derivatives such as semicarbazide (SC) methoxyamine (MeA) reacted hard nucleophiles trap aldehydes imine derivatives. Cysteine (Cys) homocysteine (HCys) captured both...
We found that a fatty liver was easily induced in novel experimental animal, Suncus murinus (suncus), by withholding food. Hepatic triglyceride content increased linearly for up to 24 h after fasting these animals. Serum levels of neutral lipids are very low the fed state compared with those rats, and decreased significantly fasting. On other hand, serum free acids, which at same level animals as threefold suncus. In order learn whether is an unusual physiological or pathological on-going...
To investigate the molecular mechanisms of lung cancer-induced bone metastasis, we established a bone-seeking subclone (HARA-B4) from human squamous cancer cell line (HARA) using an in vivo selection method. We compared comprehensive gene expression profiles between HARA and HARA-B4, identified critical factors for formation metastasis vitro assays. The number metastatic colonies hind legs was significantly higher HARA-B4-inoculated mice than HARA-inoculated at 4 weeks after inoculation. In...
Peritoneal dissemination is a frequent occurrence in pancreatic cancer, which associated with poor prognosis. MET the progression of cancer; therefore, we evaluated effect inhibitor, crizotinib, on peritoneal cancer. Crizotinib inhibited growth 8 cancer cell lines IC50 ranging from 1.4 to 4.3 µM. Invasion line Suit-2, was suppressed vitro at concentration 1.0 µM, sufficient for inhibition phosphorylation. This invasion also recapitulated by reduction expression Suit-2 siRNA. RhoA activation...
We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also HL-60 These results suggest pyridine substituted with groups the consequent change of resonance structure may an important role induction apoptosis.
Twenty-four-hr patterns of plasma corticosterone levels were determined at 4-hr intervals every 3-4 weeks in sighted and blinded pinealectomized rats adult age. Through the whole period experiment, 24-hr food intake also measured weekly.The manifested same for 15 after pinealectomy as those observed intact control rats. The magnitude peak amount did not differ between two groups.A phase shift circadian rhythms was both groups rats, with without pinealectomy. Between groups, essentially...
The binding of the new diuretic piretanide and two other diuretics (furosemide bumetanide) to serum proteins (especially albumin) was studied using in vitro equilibrium dialysis method. Piretanide bumetanide, similar each chemical structure, were almost equal constant purified albumin, while furosemide greater than that diuretics. these loop dilutions sera from healthy adults patients with renal failure or liver disease also by same Protein drugs markedly reduced failure. cause could only...