A5091279839- Viral-associated cancers and disorders
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Hedgehog Signaling Pathway Studies
- Vascular Tumors and Angiosarcomas
- DNA Repair Mechanisms
Hospital de Câncer de Barretos
2019-2023
The XAF1 -E134* variant increases the cancer risk for carriers of TP53 -R337H allele.
Abstract Management of locally advanced head and neck squamous cell carcinoma (HNSCC) requires a multi-prong approach comprising surgery, radiation and/or chemotherapy, yet outcomes are limited. This is largely due to paucity biomarkers that can predict response specific treatment modalities. Here, we evaluated TGFβ3 protein levels in extracellular vesicles (EVs) released by HNSCC cells as predictor for chemoradiation therapy (CRT). To this end, EV-fractions were isolated from lines or...
Sarcomas represent less than 1% of all solid neoplasms in adults and over 20% children. Their etiology is unclear, but genetic susceptibility plays an important role this scenario. Sarcoma central Li-Fraumeni Syndrome (LFS), a familial predisposition cancer syndrome. In Brazil, the high prevalence p.Arg337His mutations TP53 gene brings about unique condition: cluster LFS. present work, we studied 502 sarcoma patients not selected by age or family history attempt to assess impact so-called...
Breast and ovarian tumors with pathogenic variants in BRCA1 or BRCA2 genes are more sensitive to poly (ADP-ribose) polymerase inhibitors (PARPi) treatment than wildtype tumors. Pathogenic non-BRCA1/2 homologous recombination repair (HRR) also concede sensitivity PARPi treatment. RAD50 participates the Mre11-RAD50-Nbn (MRN) complex of HRR pathway plays an important role DNA repair.The objective this study is evaluate whether protein deficiency modulates response breast cancer cell lines.T47D...