A5020628194- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Hemophilia Treatment and Research
- Neuroblastoma Research and Treatments
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Nutrition, Genetics, and Disease
- Histone Deacetylase Inhibitors Research
- Blood Coagulation and Thrombosis Mechanisms
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Viral Infections and Vectors
- BRCA gene mutations in cancer
- Biological Research and Disease Studies
- FOXO transcription factor regulation
- Education Pedagogy and Practices
- Mosquito-borne diseases and control
- Genomics and Rare Diseases
- Immune responses and vaccinations
- Healthcare Regulation
Universidade Federal do Rio Grande do Sul
2012-2023
Universidade do Vale do Rio dos Sinos
2022-2023
Hospital de Clínicas de Porto Alegre
2016-2023
Universidade Federal de Minas Gerais
2021
Pontifícia Universidade Católica de Minas Gerais
2019
KU Leuven
2016
Escola Bahiana de Medicina e Saúde Pública
2016
Fundação Oswaldo Cruz
2016
Biomedical sciences, and in particular biomarker research, demand efficient glycoprotein enrichment platforms. Herein magnetic nanoprobes (MNP), after being coated with three broad-spectrum lectins-concanavalin A (ConA), wheat germ agglutinin (WGA), Maackia amurensis lectin (MA)-were utilized to selectively capture glycoproteins from human body fluids. Additionally, a new methodology, based on protection of the lectins their target sugars prior coupling MNPs, was proposed overcome...
A autofagia pode ser definida como um mecanismo celular ativado quando alguma organela está envelhecida ou disfuncional, levando à degradação dos seus componentes para fins de geração energia. Ela atua supressor tumoral oncogênico, assumindo papel dúbio na tumorigênese. Vários estudos têm descrito alterações expressão microRNAs (miRNAs) que modulam o processo autofágico em diferentes tipos tumorais. O objetivo do presente estudo foi revisar conceitos básicos sobre a autofagia, bem...
This article aims to evaluate some important molecular aspects of gastric adenocarcinoma (STAD), and its relationship with Schwann cells other factors associated perineural invasion. It is an analysis open access genomic proteomic data. Our study allowed us identify differentially expressed genes in STAD, 1382 increased 1490 decreased genes. These are a total 66 altered pathways, which we selected 7 for further (“PI3K-Akt”, “cytochrome P450 drug metabolism”, “renin secretion”,...
O neuroblastoma é um dos tumores sólidos mais prevalentes na infância, responsável por uma proporção significativa das mortes câncer pediátrico. Devido à sua marcada heterogeneidade genética e clínica, o diagnóstico tratamento do representam desafios substanciais. Este estudo revisa os principais avanços nas estratégias diagnósticas terapêuticas atuais, com ênfase no estadiamento imagem, identificação de marcadores moleculares desenvolvimento terapias personalizadas. A incorporação exames...
O1 Tumour heterogeneity: what does it mean? Dow-Mu Koh O2 Skeletal sequelae in adult survivors of childhood cancer Sue Creviston Kaste O3 Locoregional effects breast treatment Sarah J Vinnicombe O4 Imaging therapy-induced CNS toxicity Giovanni Morana, Andrea Rossi O5 Screening for lung Christian J. Herold O6Risk stratification nodules Theresa C. McLoud O7 PET imaging pulmonary Kirk A Frey O8 Transarterial tumour therapy Bernhard Gebauer O9 Interventional radiology paediatric oncology Derek...
<b><i>Objective:</i></b> Ewing sarcoma (ES) is a type of childhood cancer probably arising from stem mesenchymal or neural crest cells. The epidermal growth factor receptor (EGFR) acts as driver oncogene in many types solid tumors. However, its involvement ES remains poorly understood. <b><i>Methods:</i></b> Human SK-ES-1 and RD-ES cells were treated with EGF, the EGFR inhibitor tyrphostin (AG1478), phosphoinositide 3-kinase (PI3K)...
Summary A total of 76 unrelated male patients with mild ( n = 55) or moderate 21) haemophilia living in the southern Brazilian state Rio Grande do Sul were studied by direct sequencing all F8 26 exons, 5′ UTR and 3′ , intron–exon junctions promoter region. When no mutation was found, a multiplex ligation‐dependent probe amplification analysis performed. We identified disease‐causing mutations 69 patients, who showed 33 different mutations: 27 missense, one small deletion, two duplications...
The investigation of conventional complete blood-count (CBC) data for classifying the SARS-CoV-2 infection status became a topic interest, particularly as complementary laboratory tool in developing and third-world countries that financially struggled to test their population. Although hematological parameters COVID-19-affected individuals from Asian USA populations are available, there no descriptions comparative analyses CBC findings between COVID-19 positive negative cases Latin American...
In trials evaluating the immune responses to Bacille of Calmette-Guérin (BCG), genetic background and nutritional status are host-related factors that could affect heterogeneity in these parameters. The IFNG+874 A/T (rs 62559044) polymorphism has been reported influence IFN-γ production by BCG-vaccinated individuals challenged vitro with mycobacterial antigens. body mass index (BMI) is a proxy for associated both susceptibility tuberculosis response. We show although was not randomized...
Haemophilia A is an X-linked bleeding disorder caused by reduced or absent clotting factor VIII (FVIII) activity, determined heterogeneous mutations in the F8 gene. Identification of these pathogenic important for genetic counseling and assessment clinical manifestations. Although more than 700 gene have been reported as responsible severe haemophilia (FVIII: C<1%), corresponding data currently insufficient southern Brazilian populations, world reviews concerning changes are scarce....
Zika virus (ZIKV) cause Congenital Syndrome (CZS) in individuals exposed during pregnancy. Studies have shown that ZIKV infection positively regulates the miR-124 expression neural cells, which leads to a decrease of TFRC, gene targeted this miRNA. Both and TFRC exhibit pivotal role nervous system development. Therefore, study we aimed investigate whether genetic variants affect these genes could act together with increase risk developing CZS. rs406271 MIR-124-1 rs531564 polymorphisms were...
Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition caused by pathogenic germline variants in the TP53 gene, characterized a to development of broad spectrum tumors at early age. The core related LFS are bone and soft tissue sarcomas, premenopausal breast cancer, brain tumors, adrenocortical carcinomas (ACC), leukemias. revised Chompret criteria has been widely used establish clinical suspicion support variant testing diagnosis. Information on (PV) prevalence when using...
Abstract There is an urgent need for advances in the treatment of Ewing sarcoma (EWS), aggressive childhood tumor with possible neuroectodermal origin. Inhibition histone deacetylases (HDAC) can revert aberrant epigenetic states and reduce growth different experimental cancer types. Here, we investigated whether potent HDAC inhibitor, sodium butyrate (NaB) has ability to reprogram EWS cells towards a more differentiated state affect their survival. Exposure two cell lines NaB resulted rapid...