A5010510938- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Testicular diseases and treatments
- HIV/AIDS oral health manifestations
- Bayesian Methods and Mixture Models
- Oral Health Pathology and Treatment
- Fetal and Pediatric Neurological Disorders
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Statistical Methods and Bayesian Inference
- Streptococcal Infections and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Birth, Development, and Health
- Statistical Methods in Clinical Trials
- Oral and gingival health research
- Prenatal Screening and Diagnostics
- dental development and anomalies
- Dental Research and COVID-19
- Folate and B Vitamins Research
- Hedgehog Signaling Pathway Studies
- Cholesterol and Lipid Metabolism
- Head and Neck Cancer Studies
- Sperm and Testicular Function
Brigham and Women's Hospital
2021-2024
Harvard University
2014-2024
Seattle Children's Hospital
2004-2019
Columbia University
2019
University of Washington
2006-2016
Forsyth Technical Community College
2016
Shriners Hospitals for Children - Chicago
2008-2015
University of Illinois Chicago
2015
Harvard University Press
2013
Novant Health Forsyth Medical Center
2012
Dental implants have become an increasingly popular treatment choice for replacing missing teeth. Yet, little is known about the prevalence and sociodemographic distribution of dental implant use in United States. To address this knowledge gap, we analyzed data from 7 National Health Nutrition Examination Surveys 1999 to 2016. We estimated among adults any teeth each survey period overall as stratified by characteristics. calculated absolute relative differences 1999-2000 2015-2016 fit...
Abstract Periodontitis is a biofilm-induced inflammatory disease characterized by dysbiosis of the commensal periodontal microbiota. It unclear how natural regulation inflammation affects biofilm. Promoters active resolution inflammation, including resolvin E1 (RvE1), effectively treat periodontitis in animal models. The goals this study were 1) to compare tissue gene expression different clinical conditions, 2) determine impact local on composition subgingival bacteria, and 3) understand...
Susceptibility to testicular germ cell tumors (TGCT) has a significant heritable component, and genome-wide association studies (GWASs) have identified with variants in several genes, including KITLG , SPRY4 BAK1 TERT DMRT1 ATF7IP . In our GWAS, we genotyped 349 TGCT cases 919 controls replicated top hits an independent set of 439 960 attempt find novel susceptibility loci. We second marker (rs7040024) the doublesex mab-3-related transcription factor 1 ( ) gene that is previously described...
We compared the developmental status of school-age children with single-suture craniosynostosis (case group) and unaffected (control group). Within case group we performance distinguished by location suture fusion (sagittal, metopic, unicoronal, lambdoid).
Bacteria that are recalcitrant to genetic manipulation using modern in vitro techniques termed genetically intractable. Genetic intractability is a fundamental barrier progress hinders basic, synthetic, and translational microbiology research development beyond few model organisms. The most common underlying causes of restriction-modification (RM) systems, ubiquitous defense mechanisms against xenogeneic DNA hinder the use approaches vast majority bacteria exhibit strain-level variation....
The incidence of testicular germ cell tumors (TGCTs) has been increasing the past 4 to 6 decades; however, exposures that account for this rise have not identified. Marijuana use also grew during same period, and it established chronic marijuana produces adverse effects on human endocrine reproductive systems. In study, authors tested hypothesis is a risk factor TGCT.A population-based, case-control study 369 men ages 18 44 years who were diagnosed with TGCT from January 1999 through 2006...
We assessed the neurodevelopment of infants with and without deformational plagiocephaly (DP), at an average age 6 months.The Bayley Scales Infant Development III (BSID-III) were administered to 235 case subjects 237 demographically similar, control participants. Three-dimensional head photographs randomized rated for severity deformation by 2 craniofacial dysmorphologists who blinded status.We excluded no photographic evidence DP 70 judged have some degree DP. With age, gender,...
<h3>Objective</h3>To determine whether the heightened risk of developmental delays seen in infancy patients with deformational plagiocephaly (DP) continues into toddler years.<h3>Design</h3>Longitudinal study comparing development children and without DP, assessments (mean age, 7 months) at age 18 months.<h3>Setting</h3>Infants DP were recruited from a large craniofacial center, unaffected infants research registry.<h3>Participants</h3>The included 227 232 previously diagnosed DP.<h3>Main...
Object Although most infants with single-suture craniosynostosis (SSC) appear to have neurodevelopmental test scores in the average range, SSC has been associated cognitive and motor delays during infancy. Whether when surgery improves such deficits are not yet known. The authors aimed compare pre- postsurgical status of patients those control without craniosynostosis. Methods conducted a large, multicenter, longitudinal study 168 115 controls synostosis who were similar age, race, sex,...
OBJECTIVES: Infants and toddlers with deformational plagiocephaly (DP) have been shown to score lower on developmental measures than unaffected children. To determine whether these differences persist, we examined development in 36-month-old children without a history of DP. METHODS: Participants included 224 DP 231 diagnosed DP, all who had followed longitudinal study since infancy. confirm the presence or absence pediatricians blinded children’s case status rated 3-dimensional cranial...
White-spot lesions (WSL) associated with orthodontic appliances are a cosmetic problem and increase risk for cavities. We characterized the microbiota of WSL, accounting confounding due to gingivitis. Participants were 60 children fixed appliances, aged between 10 19 yrs, half WSL. Plaque samples assayed by 16S rRNA-based microarray (HOMIM) PCR. Mean gingival index was positively WSL (p = 0.018). Taxa included Granulicatella elegans 0.01), Veillonellaceae sp. HOT 155 < Bifidobacterium...
<h3>Objective</h3>To evaluate the hypothesis that 3-year-old children with single-suture craniosynostosis would receive lower neurodevelopmental scores than a comparable group of born patent sutures.<h3>Design</h3>Longitudinal comparison study.<h3>Setting</h3>Five tertiary care craniofacial centers.<h3>Participants</h3>Patients (cases) and without (controls). Patients diagnosed from 2002 to 2006 were eligible as cases. Controls frequency-matched cases on age, sex, race, socioeconomic status,...
Background: Quantification of facial characteristics is important for research in dysmorphology, otolaryngology, oral and maxillofacial, plastic surgical disciplines, among others. Three-dimensional surface imaging systems offer a quick practical method quantifying craniofacial variation appear to be highly reliable. However, some sources measurement error have not yet been thoroughly evaluated. Methods: The authors assessed the reliability using stereophotogrammetry measuring 40...
Study Objectives: Sleep problems in children with fetal alcohol spectrum disorders (FASD) are reportedly common but not well characterized.Objectives were to: (1) assess sleep concerns FASD using a caregiver-report survey, the Children's Habits Questionnaire (CSHQ); (2) compare CSHQ results those of previously reported community sample; and (3) describe pilot polysomnography fi ndings FASD.Methods: Children recruited from behavioral intervention study, participating caregivers completed...
Abstract Objective: To investigate the association between craniofacial anomalies and diagnosis with obstructive sleep apnea (OSA) in a large, population‐based sample of children. Design: Retrospective case–control study. Methods: Cases OSA (n = 1,203) were identified by International Classification Diseases‐9 codes consistent 1987–2003 Washington State inpatient discharge database among children ≤18 years age born state. For each case, five controls without 6,015) randomly selected from...
The foreign body response is modulated by a dynamic soft reservoir altering the biomechanics of peri-implant tissue.
Rationale: Idiopathic Pulmonary Arterial Hypertension (IPAH) is characterized by extensive pulmonary vascular remodeling due to plexiform and obliterative lesions, media hypertrophy, inflammatory cell infiltration, alterations of the adventitia. Objective: Test hypothesis that microscopic IPAH lesions express unique molecular profiles, which collectively are different from control arteries. Methods: We used digital spatial transcriptomics profile genome-wide differential transcriptomic...
The early-life environment and its effect on growth maturation of children adolescents are associated with several adult chronic diseases, including Alzheimer's disease. Because it is not feasible to collect information prospectively over the average life span, methods reconstruct aged necessary evaluate these associations. In a community-based case-control study conducted in United States, we collected U.S. census records birth certificates socioeconomic each elderly subject. Information...
1) To compare nasendoscopy (NE) and multiview fluoroscopy (MVF) in assessing velopharyngeal gap size; 2) to determine the relationship between these assessments insufficiency (VPI) severity.Retrospective review of consecutive patients with VPI at a tertiary care children's hospital, assessed NE MVF 1996 2003.177 subjects. areas were correlated (R = 0.34, 95% CI 0.26-0.41). In adjusted analysis, severity was associated with: area (OR 2.78, 1.96-3.95), 1.64, 1.37-1.95), 3) age <5 years 3.30,...
The structure of pancreatic cholesterol esterase, an enzyme that hydrolyzes a wide variety dietary lipids, mediates the absorption esters, and is dependent on bile salts for optimal activity, determined to 1.6 Å resolution. A full-length construct, mutated eliminate two N-linked glycosylation sites (N187Q/N361Q), was expressed in HEK 293 cells. Enzymatic activity assays show purified, recombinant, mutant has identical native, glycosylated purified from bovine pancreas. monomeric exhibits...
Objectives: To describe infant and maternal characteristics among infants with plagiocephaly to quantify time trends in potential risk factors for plagiocephaly. Design: Case-only study. We described the of individuals born between 1987 2002. also compared from through 1990, before American Academy Pediatrics 1992 sleep-position recommendations, those 1991 Setting: Children's Craniofacial Center at Hospital Regional Medical Seattle, Washington. Participants: Subjects included 2733 diagnosed...