A5090977864- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Prenatal Screening and Diagnostics
- dental development and anomalies
- Tumors and Oncological Cases
- Tracheal and airway disorders
- Congenital heart defects research
- Reconstructive Facial Surgery Techniques
- Hedgehog Signaling Pathway Studies
- Congenital Ear and Nasal Anomalies
- Orthodontics and Dentofacial Orthopedics
- Breastfeeding Practices and Influences
- Fetal and Pediatric Neurological Disorders
- Facial Trauma and Fracture Management
- Family and Disability Support Research
- Infant Health and Development
- Congenital Anomalies and Fetal Surgery
- Emotion and Mood Recognition
- Childhood Cancer Survivors' Quality of Life
- Ocular Disorders and Treatments
- Ear and Head Tumors
- Face recognition and analysis
- Face Recognition and Perception
- Occupational and environmental lung diseases
- Infant Development and Preterm Care
Seattle Children's Hospital
2016-2025
University of Washington
2015-2025
Google (United States)
2023-2024
New York University
2023
Seattle University
2007-2022
American Society of Neuroradiology
2021
Committee on Publication Ethics
2021
Neurological Surgery
2021
Triangle
2019
Indianapolis Zoo
2019
With the current widespread use of three-dimensional (3D) facial surface imaging in clinical and research environments, there is a growing demand for high-quality craniofacial norms based on 3D technology. The principal goal Facial Norms (3DFN) project was to create an interactive, Web-based repository images measurements. Unlike other repositories, users can gain access both summary-level statistics individual-level data, including landmark coordinates, 3D-derived anthropometric...
Abstract Craniofacial microsomia (CFM) is the second most common congenital facial anomaly, yet its genetic etiology remains unknown. We perform whole-exome or genome sequencing of 146 kindreds with sporadic (n = 138) familial 8) CFM, identifying a highly significant burden loss function variants in SF3B2 (P 3.8 × 10 −10 ), component U2 small nuclear ribonucleoprotein complex, probands. describe twenty individuals from seven harboring de novo transmitted haploinsufficient . Probands display...
We assessed the neurodevelopment of infants with and without deformational plagiocephaly (DP), at an average age 6 months.The Bayley Scales Infant Development III (BSID-III) were administered to 235 case subjects 237 demographically similar, control participants. Three-dimensional head photographs randomized rated for severity deformation by 2 craniofacial dysmorphologists who blinded status.We excluded no photographic evidence DP 70 judged have some degree DP. With age, gender,...
<h3>Objective</h3>To determine whether the heightened risk of developmental delays seen in infancy patients with deformational plagiocephaly (DP) continues into toddler years.<h3>Design</h3>Longitudinal study comparing development children and without DP, assessments (mean age, 7 months) at age 18 months.<h3>Setting</h3>Infants DP were recruited from a large craniofacial center, unaffected infants research registry.<h3>Participants</h3>The included 227 232 previously diagnosed DP.<h3>Main...
OBJECTIVES: Infants and toddlers with deformational plagiocephaly (DP) have been shown to score lower on developmental measures than unaffected children. To determine whether these differences persist, we examined development in 36-month-old children without a history of DP. METHODS: Participants included 224 DP 231 diagnosed DP, all who had followed longitudinal study since infancy. confirm the presence or absence pediatricians blinded children’s case status rated 3-dimensional cranial...
Background: Quantification of facial characteristics is important for research in dysmorphology, otolaryngology, oral and maxillofacial, plastic surgical disciplines, among others. Three-dimensional surface imaging systems offer a quick practical method quantifying craniofacial variation appear to be highly reliable. However, some sources measurement error have not yet been thoroughly evaluated. Methods: The authors assessed the reliability using stereophotogrammetry measuring 40...
Craniofacial microsomia (CFM) is one of the most common congenital conditions treated in craniofacial centers worldwide. This condition variably associated with anomalies jaws, ears, facial soft tissue, orbits, and nerve function can be extracranial anomalies. The cause this unknown, though CFM has been withprenatalexposures genetic abnormalities. Diagnosis, treatment, outcome assessment challenging due to wide phenotypic spectrum observed condition. Surgical treatment requires a coordinated...
Introduction The metopic suture is the only calvarial which normally closes during infancy. Upon closure, a palpable and visible ridge often forms can be confused with craniosynostosis. Metopic ridging (MR) treated nonsurgically while craniosynostosis (MCS) surgically. Differentiating between two paramount; however, consensus lacking about where clear diagnostic threshold lies. goal of this study to describe physical examination CT scan characteristics may help differentiate physiological...
Although craniofacial sex differences have been extensively studied in humans, relatively little is known about when various dimorphic features manifest during postnatal life. Using cross-sectional data derived from the 3D Facial Norms repository, we tested for sexual dimorphism of soft-tissue morphology at different ages. One thousand five hundred fifty-five individuals, pre-screened conditions, between 3 and 25 years age were placed to one six age-defined categories: early childhood, late...
Abstract We report on three unrelated patients with the 22q11.2 microdeletion syndrome (del22q11) who have phenotypic anomalies compatible oculo‐auriculo‐vertebral spectrum (OAVS). Hemifacial microsomia, unilateral microtia, hearing loss, congenital heart/aortic arch arteries defects, and feeding difficulties were present in all patients. Additional occasionally diagnosed included coloboma of upper eyelid, microphthalmia, cerebral malformation, palatal anomalies, neonatal hypocalcemia,...
Background: Craniofacial microsomia is one of the most common conditions treated by craniofacial teams. However, research regarding cause this condition or surgical outcomes treatment scant. This attributable to lack diagnostic criteria and wide phenotypic spectrum. Standardized description malformations associated with a necessary first step for multicenter, interdisciplinary into complex condition. Methods: The authors used previously published pictorial Orbit, Mandible, Ear, Nerve, Soft...
Surgical and orthodontic treatment of unilateral cleft lip +/- palate can produce dramatic changes in nasolabial form; however, the lack ideal methods with which to objectively document three-dimensional form limits ability assess outcomes. The purpose this study was determine reliability stereophotogrammetry for anthropometric assessment deformity infants before repair.Preoperative images were acquired from 26 consecutive patients unrepaired palate. Three raters performed indirect...
Background: Craniofacial microsomia (CFM) is a congenital condition associated with malformations of the bone and soft tissue face facial nerves, all which have potential to impair expressiveness. We investigated whether CFM-related variation in expressiveness evident as early infancy. Methods: Participants were 113 ethnically diverse 13-month-old infants (n = 63 cases CFM n 50 unaffected matched controls). They observed 2 emotion induction tasks designed elicit positive negative effects....
Quantitative measures of facial form to evaluate treatment outcomes for cleft lip (CL) are currently limited. Computer-based analysis three-dimensional (3D) images provides an opportunity efficient and objective analysis. The purpose this study was define a computer-based standard identifying the 3D midfacial reference plane face in children with unrepaired measurement symmetry.The 50 subjects (35 unilateral CL, 10 bilateral five controls) were included study.Five methods defining applied...
Background Craniofacial microsomia (CFM) is a congenital condition with wide phenotypic variability, including hypoplasia of the mandible and external ear. We assembled cohort children facial features within CFM spectrum without known craniofacial anomalies. sought to develop standardized approach assess describe characteristics study cohort, using multiple sources information gathered over course this longitudinal create case subgroups shared features. Methods Participants were enrolled...
Objective Children with craniofacial microsomia (CFM) have complex healthcare needs, resulting in evaluations and interventions from infancy onward. Yet, little is understood about families’ treatment experiences or the impact of CFM on caregivers’ well-being. To address this gap, NIH-funded ‘Craniofacial microsomia: Accelerating Research Education (CARE)’ program sought to develop a conceptual thematic framework caregiver adjustment CFM. Design Caregivers reported their child's medical...