A5037197737- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Prenatal Screening and Diagnostics
- Air Quality and Health Impacts
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Telemedicine and Telehealth Implementation
- Atrial Fibrillation Management and Outcomes
- Dental Health and Care Utilization
- Cardiovascular Effects of Exercise
- Family and Disability Support Research
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Prenatal Substance Exposure Effects
- Language Development and Disorders
- Fatty Acid Research and Health
- Dental Anxiety and Anesthesia Techniques
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Noise Effects and Management
- Cardiac Arrest and Resuscitation
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
University of the West
2025
Dana-Farber Cancer Institute
2025
University of Washington
2014-2024
Seattle Children's Hospital
2014-2023
University of North Carolina at Chapel Hill
2021-2023
Seattle University
2012-2022
Institute of Behavioral Sciences
2019
Shriners Hospitals for Children - Erie
2016
University of Illinois Chicago
2016
Yahoo (United Kingdom)
2016
We compared the developmental status of school-age children with single-suture craniosynostosis (case group) and unaffected (control group). Within case group we performance distinguished by location suture fusion (sagittal, metopic, unicoronal, lambdoid).
Severe maternal morbidity (SMM) is a serious health condition potentially resulting in death without immediate medical attention, including organ failure, obstetric shock and eclampsia. SMM affects 20000 US women every year; however, few population-based studies have examined risk factors.We conducted case-control study linking birth certificate hospital discharge data from Washington State (1987-2008), identifying 9485 with an antepartum, intrapartum or postpartum ≥3-day hospitalisation...
Recent reports have linked variability in visit-to-visit systolic blood pressure (SBP) to risk of mortality and stroke, independent the effect mean SBP level. This study aimed evaluate whether is associated with all-cause mortality, incident myocardial infarction (MI), or trends levels over time. The Cardiovascular Health Study a longitudinal cohort vascular factors disease elderly. Participants who attended their first 5 annual clinic visits experienced no event before 5th visit were...
Abstract Objective: To evaluate the effect of ovarian cancer risk on performance serum biomarkers mesothelin, human epididymis protein 4 (HE4), and CA125. Methods: We measured HE4, CA125 levels from women with invasive (n = 143), benign gynecologic conditions 124), controls 344). Demographic, epidemiologic, reproductive, medical, family history data were collected using a standardized questionnaire. Pedigree BRCA 1/2 test results used to stratify into average high-risk groups. The diagnostic...
Background Prior studies suggest that circulating fatty acids may influence the risk of atrial fibrillation ( AF ), but little is known about associations saturated with . Methods and Results The study population included 2899 participants from Cardiovascular Health Study, a community‐based longitudinal cohort adults aged 65 years or older in United States who were free prevalent coronary heart disease 1992. Cox regression was used to assess association all long‐chain acids—palmitic acid...
: media-1vid110.1542/5972296741001PEDS-VA_2018-2373Video Abstract BACKGROUND: Studies have revealed an association between positional plagiocephaly and/or brachycephaly (PPB) and development, although little is known about long-term outcomes. We examined cognition academic achievement in children with without PPB, testing the hypothesis that who had PPB as infants would score lower than controls.We enrolled 187 school-aged a history of 149 controls. Exposures were presence or absence...
Abstract Objective: To evaluate if serum levels of candidate ovarian cancer biomarkers vary with individual characteristics healthy women who are likely candidates for an screening program. Methods: We analyzed CA125, mesothelin, and HE4 in a sample 155 postmenopausal at increased risk developing based on personal family history. Information reproductive, medical histories, lifestyle factors, anthropometry was collected by self-report. Twenty-two factors were examined using univariate...
Children with single-suture craniosynostosis (SSC) have higher rates of learning disabilities and related neurocognitive problems than unaffected peers. Executive function (EF) attention are thought to be areas particular vulnerability, though studies date been limited by small sample sizes a lack control groups. We evaluated 179 school-aged children SSC (cases) 183 controls at an average age 7 years using clinician-administered parent teacher report measures EF attention. Among SSC, we...
OBJECTIVE The language and memory functions of children with without single-suture craniosynostosis (SSC) were compared at school age (mean 7.45 years, standard deviation [SD] 0.54 years). in this cohort originally recruited infancy prior to cranial surgery for those SSC. METHODS Individual evaluations 179 school-aged SSC 183 controls conducted (70% the original cohort) using standardized measures language, learning, memory. Parents participated an interview about specialized education...
Epidemiological evidence for gestational polycyclic aromatic hydrocarbon (PAH) exposure and adverse child cognitive outcomes is mixed; little known about critical windows of exposure.
Atrial fibrillation is increasingly prevalent as the US population ages and associated with significant morbidity mortality. Care for patients atrial can be costly, health care costs are comparatively high, there few cost estimates available that incorporate detailed measurement of comorbidities their effects on costs.In Cardiovascular Health Study Framingham Heart Study, participants aged 65 years or older newly diagnosed were matched age follow-up time to referents free fibrillation. The...
Background: Previous research has observed higher than average rates of behavior problems in school-age children with single-suture craniosynostosis. However, most studies used a single informant (mothers) and did not include comparison groups to control for sociodemographic factors. Methods: The authors gave standardized checklists the mothers, fathers, teachers 179 elementary school craniosynostosis 183 controls. We linear regression compare without on continuous measures adjustment,...
Background: Craniofacial microsomia (CFM) is a congenital condition associated with malformations of the bone and soft tissue face facial nerves, all which have potential to impair expressiveness. We investigated whether CFM-related variation in expressiveness evident as early infancy. Methods: Participants were 113 ethnically diverse 13-month-old infants (n = 63 cases CFM n 50 unaffected matched controls). They observed 2 emotion induction tasks designed elicit positive negative effects....
Background Parent‐led toothbrushing effectively reduces early childhood caries. Research on the strategies that parents use to promote this behavior is, however, lacking. Aim To examine associations between parent–child interactions and child oral health using a newly developed measure, Toothbrushing Observation System ( TBOS ). Design One hundred children ages 18–60 months their were video‐recorded during interactions. Using these recordings, six raters coded parent behaviors duration of...
Background: Surgical repair for craniosynostosis varies depending on the infant’s age, location of suture fusion, and approach (e.g., open versus endoscopic). Existing data suggest possible racial ethnic disparities in timely access to surgical care that may, turn, be associated with perioperative outcomes. This study examined variation operations by Methods: Data were collected 2013 2015 Pediatric National Quality Improvement Program. Patients aged younger than 24 months diagnoses procedure...
Background Craniofacial microsomia (CFM) is a congenital condition with wide phenotypic variability, including hypoplasia of the mandible and external ear. We assembled cohort children facial features within CFM spectrum without known craniofacial anomalies. sought to develop standardized approach assess describe characteristics study cohort, using multiple sources information gathered over course this longitudinal create case subgroups shared features. Methods Participants were enrolled...
Animal and epidemiological studies suggest that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may negatively impact toddler neurodevelopment.We investigated this association in 835 mother-child pairs from CANDLE, a diverse pregnancy cohort the mid-South region of U.S. PAH metabolite concentrations were measured mid-pregnancy maternal urine. Cognitive Language composite scores at ages 2 3 years derived Bayley Scales Infant Toddler Development, 3rd edition (Bayley-3). Behavior...
<h3>Objective</h3> Resting heart rate (RHR) is an established predictor of myocardial infarction (MI) and mortality, but the relationship between variation in RHR over a period several years health outcomes unclear. We evaluated long-term risks incident MI mortality among older adults. <h3>Methods</h3> 1991 subjects without cardiovascular disease from Cardiovascular Health Study were included. was taken resting ECGs at first five annual study visits. mean, trend estimated with linear...
OBJECTIVE Single-suture craniosynostosis (SSC), the premature fusion of a cranial suture, is characterized by dysmorphology craniofacial skeleton. Evidence to suggest that children with SSC are at an elevated risk mild moderate developmental delays and neurocognitive deficits mounting, but associations among suture fusion, neuroanatomy, neurocognition unexplained. The goals this study were determine 1) whether differences in brain present young 2 most common forms (sagittal metopic) several...
Background Globally, flooding is one of the severe consequences climate change, which exacerbated by urbanization and inadequate infrastructure. In Trinidad Tobago, floods affect a sizable proportion population pose major public health hazard. Aim This study assessed psychosocial impact on adult residents in flood-prone areas focusing prevalence mental conditions such as depression, anxiety, stress, post-traumatic stress disorder (PTSD), along with identifying associated factors predictors...
517 Background: The CDK4/6 inhibitor abemaciclib (abema) is approved with adjuvant endocrine therapy (ET) for high-risk node positive hormone receptor (HR+) HER2- breast cancer. This regimen reduces cancer recurrence, yet may be complicated by toxicity, limiting patient (pts) ability to maintain dose or continue medication. In the phase III monarchE study, 25.8% of pts discontinued abema early reasons other than 18.5% adverse events (AEs), and 43.6% required reduction. Experiences targeted...