A5026579039- Genetics, Aging, and Longevity in Model Organisms
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics and Neurodevelopmental Disorders
- Photoreceptor and optogenetics research
- Physiological and biochemical adaptations
- Nutrition, Genetics, and Disease
- Signaling Pathways in Disease
- Alcohol Consumption and Health Effects
- Fungal and yeast genetics research
- Sirtuins and Resveratrol in Medicine
- Regulation of Appetite and Obesity
- Insect Resistance and Genetics
- Forensic Entomology and Diptera Studies
- 3D Printing in Biomedical Research
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Fatty Acid Research and Health
Research Institute for Farm Animal Biology (FBN)
2019-2025
Qingdao University
2019-2022
University of Rochester
2022
University of Washington
2022
Ludwig-Maximilians-Universität München
2013-2019
Leibniz Association
2019
Center for Integrated Protein Science Munich
2016-2019
Urologische Klinik München
2016
University of Göttingen
2010
European Neuroscience Institute Göttingen
2010
As the human life span increases, number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that disturbances in aging brain mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation histone H4 lysine 12 (H4K12) acetylation and fail to initiate gene expression program consolidation. Restoration physiological...
The circadian clock is constituted by a complex molecular network that integrates number of regulatory cues needed to maintain organismal homeostasis. To this effect, posttranslational modifications proteins modulate rhythms and are thought convert physiological signals into changes in protein function. explore reversible lysine acetylation dependent on the clock, we have characterized acetylome WT Clock -deficient ( −/− ) mouse liver quantitative mass spectrometry. Our analysis revealed...
Article18 January 2016Open Access Transparent process Life span extension by targeting a link between metabolism and histone acetylation in Drosophila Shahaf Peleg Department of Physiological Chemistry, Biomedical Center for Integrated Protein Science Munich, Ludwig-Maximilians University, Planegg-Martinsried, Germany Molecular Biology, Search more papers this author Christian Feller Ignasi Forne Analysis Unit, Center, Evelyn Schiller Institute Experimental Genetics, Helmholtz Zentrum German...
Binge drinking and chronic exposure to ethanol contribute alcoholic liver diseases (ALDs). A potential link between ALDs circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic metabolism remains virtually unexplored. Using acute versus feeding, we reveal differential reprogramming the transcriptome in liver. Specifically, rewiring diurnal SREBP transcriptional pathway leads distinct signatures acetyl-CoA that are translated...
The body temperature of Drosophila melanogaster depends on the extrinsic temperature. Numerous studies in fruit flies have shown that environmental has an effect metabolism, lifespan and starvation resilience. We previously Chameau (Chm), a MYST-domain acetyltransferase, promotes aging but also increases As resilience is highly dependent, we explored with reduced chm expression. Strikingly, found increase 2oC was sufficient to restore mutants. rescued dampened expression genes involved...
The field of biogerontology has established itself through significant lines research in recent decades. However, despite early breakthroughs, progress understanding the aging process been slow. To push forward, new methodologies and technologies are likely needed to unravel complexity aging. This meeting brought together leading scientists innovators explore some emerging approaches, presenting groundbreaking advancements four key sessions, culminating a panel discussion.
Abstract Epigenetic deregulation, such as the reduction of histone acetylation levels, is thought to be causally linked various maladies associated with aging. Consequently, deacetylase inhibitors are suggested serve epigenetic therapy by increasing acetylation. However, previous work suggests that many non-histone proteins, including metabolic enzymes, also acetylated and post transitional modifications may impact their activity. Furthermore, were recently shown a variety proteins. By...
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known DU6, is one world's longest selection experiments high body mass and was previously described a model metabolic healthy (benign) present study further characterizes geno- phenotypes this tests its suitability an interventional obesity model. In contrast to previous findings, our data suggest...
Proteins involved in cellular metabolism and molecular regulation can extend lifespan of various organisms the laboratory. However, any improvement aging would only provide an evolutionary benefit if were able to survive under non-ideal conditions. We have previously shown that Drosophila melanogaster carrying a loss-of-function allele acetyltransferase chameau (chm) has increased healthy when fed ad libitum. Here, we show loss chm reduction its activity results substantial weight decrease...
Abstract Despite longstanding scientific interest in the centrality of mitochondria to biological aging, directly controlling mitochondrial function test causality has eluded researchers. We show that specifically boosting membrane potential through a light-activated proton pump reversed age-associated phenotypes and extended C. elegans lifespan. harnessing energy light experimentally increase during adulthood alone is sufficient slow rate aging.
Abstract Wild-type murine models for aging research have lifespans of several years, which results in long experimental duration and late output. Here we explore the short-lived non-inbred Titan mouse as a model to test longevity interventions. We show that mice exhibit increased frailty cellular senescence at an early age. Dietary intervention attenuates progression mice. Additionally, cyclic administration senolytic drug Navitoclax age increases lifespan reduces senescence. Our data...
Regulated metabolic activity is essential for the normal functioning of living cells.Indeed, altered causally linked with progression cancer, diabetes, neurodegeneration, and aging to name a few.For instance, changes in mitochondrial activity, cell's powerhouse, have been characterized many such diseases.Generally, oxygen consumption rates mitochondria were considered reliable readout measurements some these studies based on isolated or cells.However, conditions may not represent complexity...
Abstract Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The outbred mouse line Titan (DU6) results from world’s longest selection experiment high body mass and was previously described a model metabolic healthy (benign) present study deeper characterized geno- phenotypes this tested its suitability an interventional obesity model. In contrast to previous findings, our data suggests that mice...
Abstract Butyrate has been proposed as a drug therapy by acting KDAC inhibitor and elevating protein acetylation, in particular on histones. Nonetheless, recent studies suggest that tissues such the gut can utilize butyrate metabolite. We have previously shown addition of induces rapid increase oxygen consumption whole Drosophila melanogaster heads. Here we show while head is increased butyrate, no apparent changes are observed proteome acetylome. Instead, metabolized incorporated into...