A5051940263- Spinal Cord Injury Research
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Nerve injury and regeneration
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- biodegradable polymer synthesis and properties
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Tissue Engineering Materials
- Biochemical Acid Research Studies
- Inflammasome and immune disorders
- Advanced Sensor and Energy Harvesting Materials
- Cholinesterase and Neurodegenerative Diseases
Changshu No.1 People's Hospital
2020-2023
Xian Yang Central Hospital
2020-2023
Xuzhou Medical College
2021
Osteoporosis is a common disease among the ageing society. Oxidative stress caused by excessive accumulation of reactive oxygen species (ROS) aetiology osteoporosis. α-Lipoic acid (ALA) an antioxidant in body, which can eliminate excess ROS body and inhibits levels oxidative cells. Herein, we designed PEGylated hollow gold nanoparticles (HGNPs) loaded with ALA (mPEG@HGNPs-ALA) to remove treatment First, mPEG@HGNPs particle size ∼63 nm has been successfully synthesized. By comparing drug...
Herein, electrospun zinc oxide nanoparticle/poly (vinylidene fluoride) (ZnONP/PVDF) composite fiber membranes were designed, fabricated, and tested for improved orthopedic applications. A single factor screening study was conducted to determine the optimal ZnONP/PVDF formulation based on osteoblast (bone forming cells) proliferation antibacterial properties. Further, materials characterized their morphology, crystallinity, roughness, piezoelectric properties, chemistry understand such cell...
JOURNAL/nrgr/04.03/01300535-202409000-00038/figure1/v/2024-01-16T170235Z/r/image-tiff Previous studies have shown that Biochanin A, a flavonoid compound with estrogenic effects, can serve as neuroprotective agent in the context of cerebral ischemia/reperfusion injury; however, its effect on spinal cord injury is still unclear. In this study, rat model was established using heavy object impact method, and rats were then treated A (40 mg/kg) via intraperitoneal injection for 14 consecutive...
Astragaloside (AS) has an anti-osteoporotic effect, but its poor water solubility and low bioavailability limit application. In this study, a novel nano-carrier with bone targeting was prepared by modifying mPEG-PLGA alendronate (AL) before incorporation into astragaloside nano-micelles (AS-AL-mPEG-PLGA) to enhance the oral bioavailability, anti-osteoporosis effect of AS. The release behavior AS-AL-mPEG-PLGA in vitro investigated via dialysis. pharmacokinetics studied Sprague-Dawley (SD)...
Spinal cord injury (SCI) is frequently accompanied by sensorimotor deficits that persist for years in the absence of effective treatments. Biochanin A (BCA), a natural isoflavone, belongs to phytoestrogen. BCA can perform multiple functions, but its role SCI unclear. The purpose this study was explore impact and mechanism on microglia simulating with lipopolysaccharide (LPS) vitro . results showed inhibited microglial apoptosis promoted repair inducing M2 polarization secretion...
Abstract Spinal cord injury (SCI) is a highly debilitating condition that impairs neuronal function and triggers complex cascade of primary secondary damage events. Autophagy can result in cell death, which phenomenon eukaryotic cells plays an important role the development SCI. Thus, this provides practical potential target for therapeutic intervention against Enolase inhibition (ENOblock) has been demonstrated to provide neuroprotection functional recovery rat model However, it remains...