A5103188059- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Otolaryngology and Infectious Diseases
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Medicinal Plant Extracts Effects
- Drug Transport and Resistance Mechanisms
- Phytochemistry and Biological Activities
- Inflammatory mediators and NSAID effects
- Helicobacter pylori-related gastroenterology studies
- Bone Metabolism and Diseases
Zhejiang Chinese Medical University
2015-2025
China Academy of Chinese Medical Sciences
2024
Parul University
2023
Ministry of Industry and Information Technology
2022
Harbin Institute of Technology
2022
Harvard University
2016-2020
Dana-Farber Cancer Institute
2016-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Chongqing Three Gorges Central Hospital
2019
Sanofi (France)
2017
Evidence suggests a possible role of Fusobacterium nucleatum in colorectal carcinogenesis, especially right-sided proximal colorectum. Considering change bowel contents and microbiome from to distal segments, we hypothesized that the proportion carcinoma enriched with F. might gradually increase along subsites rectum cecum.A retrospective, cross-sectional analysis was conducted on 1,102 colon rectal carcinomas molecular pathological epidemiology databases Nurses' Health Study Professionals...
Although patients with resected pancreatic adenocarcinoma are at high risk for disease recurrence, few biomarkers available to inform patient outcomes.To evaluate the alterations of 4 main driver genes in and outcomes after cancer resection.This study analyzed protein expression DNA KRAS, CDKN2A, SMAD4, TP53 by immunohistochemistry next-generation sequencing formalin-fixed, paraffin-embedded tumors 356 who were treated Dana-Farber/Brigham Women's Cancer Center (October 26, 2002, May 21,...
The presence of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue has been associated with microsatellite instability (MSI), lower-level T-cell infiltrates, and poor clinical outcomes. Considering differences the tumor-immune microenvironment between MSI-high non-MSI-high carcinomas, we hypothesized that association F. immune response might differ by tumor MSI status. Using samples from 1,041 rectal colon cancer patients within Nurses' Health Study Professionals Follow-up...
Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint pathway can improve clinical outcomes in various malignancies. Evidence suggests that aspirin (a widely used nonsteroidal anti-inflammatory drug) not only prolongs colorectal cancer survival, but also activate T cell-mediated antitumor immunity and synergize with immunotherapy through inhibition prostaglandin E2 production. We hypothesized survival benefit associated might be stronger carcinoma a lower CD274...
Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cells in tumor microenvironment which mediate desmoplastic response and primary driver for an immunosuppressive microenvironment, leading to failure triple-negative breast cancer (TNBC) immunotherapy. Therefore, depleting CAFs may enhance effect immunotherapy (such as PD-L1 antibody). Relaxin (RLN) has been demonstrated significantly improve transforming growth factor-β (TGF-β) induced activation microenvironment....
Prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase-2; a target of aspirin) produces inflammatory mediator prostaglandin E2 (PGE2), and contributes to colorectal neoplasia development. PTGS2-driven responses can induce tumor expression microRNA MIR21 (miR-21) that increase local PGE2 level by downregulating PGE2-metabolizing enzymes. We hypothesized the prognostic association in carcinoma might depend on microenvironment be stronger tumors expressing high-level PTGS2.Utilizing 765...
Inhibitors targeting the PDCD1 (programmed cell death 1, PD-1) immune checkpoint pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in MicroEnvironment) classification based on tumor CD274 (PDCD1 ligand PD-L1) expression and tumor-infiltrating lymphocytes (TIL) has been proposed to predict response immunotherapy. It remains be determined clinical, pathological, molecular features of subtypes colorectal cancer. Using 812 colon rectal carcinoma cases from Nurses'...
Expression of the immune checkpoint ligand CD274 (programmed cell death 1 1, PD-L1, from gene CD274) contributes to suppression antitumor T cell-mediated response in various tumor types. However, role PDCD1LG2 (PD-L2, CD273, PDCD1LG2) microenvironment remains unclear. We hypothesized that expression might be inversely associated with lymphocytic reactions colorectal cancer. examined by IHC 823 colon and rectal carcinoma cases within two U.S.-nationwide cohort studies categorized tumors into...
Abstract Accumulating evidence suggests that metabolic reprogramming has a critical role in carcinogenesis and tumor progression. The usefulness of formalin-fixed paraffin-embedded (FFPE) tissue material for metabolomics analysis as compared with fresh frozen remains unclear. LC/MS-MS–based was performed on 11 pairs matched normal tissues both FFPE materials from patients colorectal carcinoma. Permutation t test applied to identify metabolites differential abundance between tissues. A total...
It is hypothesized that "cancer stem cells" are responsible for the resistance to chemotherapy of cancer cells in ovarian cancers.The objective studies was explore if cell biomarkers could be used predict tumor chemotherapy-resistance serous patients.Expression two putative markers CD133 and nestin, vascular epithelial growth factor (VEGF) epidermal receptor (EGFR) were detected 123 cases advanced specimens by immunohistochemistry.To estimate intra-tumoral microvessel density (MVD), CD34...
Experimental evidence suggests that the let-7 family of noncoding RNAs suppresses adaptive immune responses, contributing to evasion by tumor. We hypothesized amount let-7a and let-7b expression in colorectal carcinoma might be associated with limited T-lymphocyte infiltrates tumor microenvironment worse clinical outcome. Utilizing molecular pathological epidemiology resources 795 rectal colon cancers two U.S.-nationwide prospective cohort studies, we measured tumor-associated levels...
Evidence indicates not only carcinogenic effect of cigarette smoking but also its immunosuppressive effect. We hypothesized that the association with colorectal cancer risk might be stronger for tumors lower anti-tumor adaptive immune response.
Colorectal tumors arise with genomic and epigenomic alterations through interactions between neoplastic cells, immune microbiota that vary along the proximal to distal axis of colorectum. Long interspersed nucleotide element-1 (LINE-1) hypomethylation in colorectal cancer has been associated worse clinical outcome. Utilizing 1,317 colon rectal carcinoma cases two U.S.-nationwide prospective cohort studies, we examined patient survival according LINE-1 methylation level stratified by tumor...
A deep insight into the function and kinetics of ATP-binding cassette (ABC) transporters may aid in development pharmaceutics that can minimize particular facet chemo-resistance. We utilized bioluminescence imaging to monitor ABC transporter mediated intracellular drug efflux function. also investigated potential association between bioluminescent pharmacokinetic profiles anti-tumor efficacy coix seed extract gemcitabine against pancreatic cancer cells vitro vivo. The parameters...
Lipid nanoparticles (LNPs) are the primary non-viral vectors for siRNA delivery. However, synthetic lipids face issues, such as low lysosomal escape efficiency and high cost. This study aimed to use three natural construct LNPs, optimize their preparation freeze-drying processes, evaluate delivery in vitro. Coix seed lipid [Coix lacryma-jobi L. var. mayuen (Roman.) Stapf (Poaceae), CSL], Brucea javanica [Brucea (L.) Merr. (Simaroubaceae), BJL], Soybean oil [Glycine max (Fabaceae), SO] were...