A5082943763- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Synthesis and Biological Evaluation
- Ion channel regulation and function
- Genetic and Kidney Cyst Diseases
- Cancer Mechanisms and Therapy
- Ion Transport and Channel Regulation
- Extracellular vesicles in disease
- Synthesis and Characterization of Heterocyclic Compounds
- Ovarian cancer diagnosis and treatment
- Nanoparticles: synthesis and applications
- Synthesis and biological activity
- Pain Mechanisms and Treatments
- Quinazolinone synthesis and applications
- Chromatin Remodeling and Cancer
- Melamine detection and toxicity
- Sirtuins and Resveratrol in Medicine
- Eicosanoids and Hypertension Pharmacology
- Cancer-related gene regulation
- Natural Compounds in Disease Treatment
- Chronic Kidney Disease and Diabetes
- Immune cells in cancer
Sichuan University
2022-2024
West China Hospital of Sichuan University
2022-2024
Nankai University
2008-2023
Yale University
1993-2023
Yale Cancer Center
2020
State Key Laboratory of Medicinal Chemical Biology
2015-2018
China National Offshore Oil Corporation (China)
2011
Kunming General Hospital of Chengdu Military Command
2009
United States Department of Veterans Affairs
1994
Howard Hughes Medical Institute
1994
The Na+-Ca2+ exchanger is an important regulator of cellular Ca2+ levels, and one isoform this transporter, NCX1, has been cloned previously (Nicoll, D. A, Longoni, S., Philipson, K
Despite the increasing recognition that ATP is an important extracellular excitatory mediator in nervous system, regulation of receptors poorly understood. Because Zn2+ concentration regulated a variety biological tissues, we studied modulation ATP-gated cation channel by mammalian neurons using whole-cell patch-clamp technique. In approximately 73% cells tested, amplitude ATP-activated membrane ion current increased up to 5-fold presence micromolar concentrations Zn2+. The characteristics...
Hydroxyapatite (HA) nanoparticles have been reported to exhibit anti-tumor effects on various human cancers, but the of HA glioma cells remain unclear. The aim this study was explore whether can inhibit proliferation and induce apoptosis C6 cells. Use 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that induced cell death in a concentration-dependent time-dependent manner. Results from hoechst 33342 staining flow cytometry showed significantly. Meanwhile,...
Abstract Objectives Diabetic nephropathy is a major complication of diabetes and frequent cause end‐stage renal disease recent studies suggest that podocyte damage may play role in the pathogenesis this. At early onset diabetic there drop‐out, which thought to provoke glomerular albuminuria subsequent injury; however, underlying molecular mechanisms this remain poorly understood. Here we report tested hypothesis injury caused, at least part, by up‐regulation transient receptor potential...
Evidence shows that an abnormal deposition of amyloid beta-peptide25-35 (Aβ25-35) was the primary cause pathogenesis Alzheimer's disease (AD). And elimination Aβ25-35 is considered important target for treatment AD. Triptolide (TP), isolated from Tripterygium wilfordii Hook.f. (TWHF), has been shown to possess a broad spectrum biological profiles, including neurotrophic and neuroprotective effects. In our study investigating effect potential mechanism triptolide on cytotoxicity...
Colorectal cancer (CRC) ranks among the most prevalent malignancies worldwide, characterized by its complex etiology and slow research progress. Diabetes, as an independent risk factor for CRC, has been widely certified. Consequently, this study centers on elucidating intricacies of CRC cells initiation progression within a high-glucose environment.
Due to its high nitrogen content, melamine was deliberately added raw milk for increasing the apparent protein content. Previous studies showed that melamine-induced apoptosis and oxidative damage on PC12 cells rats' hippocampus. Several evidences suggested vitamin antioxidant reduced stress improved organic function. Whether treatments with vitamins C or E, otherwise combination of them can attenuate after administration remains be elucidated. In this study, reversible effects antioxidants...
Genetic testing in patients with suspected hereditary kidney disease may not reveal the genetic cause for disorder as potentially pathogenic variants can reside genes that are yet known to be involved disease. We have developed KidneyNetwork, utilizes tissue-specific expression inform candidate gene prioritization specifically diseases. KidneyNetwork is a novel method constructed by integrating RNA-sequencing co-expression network of 878 samples multi-tissue 31,499 samples. It uses patterns...
Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the interleukin-6 family of cytokines. In kidney, LIF regulates nephrogenesis, involves in tubular regeneration, responds pro- and anti-inflammatory stimuli, so on. also plays an essential role protective mechanisms triggered by preconditioning-induced oxidative stress. Although shows wide range biologic activities, effects on high glucose-induced stress podocytes remain unclear. The aim study was assess whether can...
Abstract Mature podocytes are highly differentiated cells with several characteristic phenotypic features that involved in the glomerular filtration function. During kidney development, a series of changes morphological characteristics and cellular functions may happen podocytes. The miR-200 family various biological pathological processes. But underlying molecular mechanisms podocyte differentiation remain poorly understood. Herein is shown miR-200a, miR-200b miR-429 significantly...
TRPC6, a member of the TRPC family, attracts much attention from public because its relationship with disease. In both brain and kidney, TRPC6 serves variety functions. The aim present study was to observe expression effects in renal cortex hippocampus during early postnatal development mouse. study, immunohistochemistry Western blotting were used detect mouse kidney day 1, 3, 5, 7, 14, 21, 28 49 (P1, P3, P5, P7, P14, P21, P28 P49). Results showed that increased hippocampus, there...
Krüppel‐like factor 5 (KLF5) both suppresses and promotes tumor growth depending on cellular context. The mechanisms underlying promotion could be targetable for therapy. Although a number of transcriptional targets KLF5 have been identified implicated in KLF5‐mediated growth, how regulates these genes remains to addressed. Here we performed coimmunoprecipitation (co‐IP) liquid chromatography–tandem mass spectrometry (LC–MS/MS) the TSU‐Pr1 bladder cancer cell line, which is shown promote...
Significance Statement Heterozygous DNAJB11 mutation carriers manifest with small cystic kidneys and renal failure in adulthood. Recessive cases prenatal kidney dysplasia were recently described. Our vitro mouse model studies investigate the proposed disease mechanism as an overlap of autosomal-dominant polycystic tubulointerstitial pathogenesis. We find that loss impairs cleavage maturation protein polycystin-1 (PC1) results dosage-dependent cyst formation mice. Dnajb11 does not activate...
SIRT1 was associated with AS risk and EPCs were reported to participate in the endothelial repair Coronary Atherosclerosis (CAS). In this study, we explored role of mice also its modulation EPCs.
The POU family of proteins binds specifically to octamer DNA motifs present in the promoters several genes and regulates their expression. We identified presence four members proteins, Oct-1, Oct-2, Oct-T1, Oct-T2, human T-cell line Jurkat. To obtain insight into physiological role played by these T cells, we studied time course expression resting, activated, phorbol 12-myristate 13-acetate (PMA)-treated cells. gene encoding Oct-1 (now assigned name OTF1 for octamer-binding transcription...