A5080702934- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Computational Drug Discovery Methods
- History and advancements in chemistry
- Analytical Chemistry and Chromatography
- Various Chemistry Research Topics
- Inorganic and Organometallic Chemistry
- Chemical Synthesis and Analysis
- Pulmonary Hypertension Research and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Asymmetric Synthesis and Catalysis
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Electron Spin Resonance Studies
- Atrial Fibrillation Management and Outcomes
- Molecular spectroscopy and chirality
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Chemistry and Chemical Engineering
- Wireless Power Transfer Systems
- Cardiac Arrest and Resuscitation
- Catalysis and Oxidation Reactions
- Heart Failure Treatment and Management
VA Greater Los Angeles Healthcare System
2005-2023
University of California, Los Angeles
2008-2023
UCLA Health
2012-2017
Ronald Reagan UCLA Medical Center
2011-2012
Los Angeles Medical Center
2012
University of Toronto
1983-2010
West Los Angeles College
1991-2006
Sumitomo Chemical (Japan)
1990-2006
United Heart and Vascular Clinic
2005
VA West Los Angeles Medical Center
2003
Atrial tachyarrhythmias (ATs) detected by implanted devices are often atrial fibrillation or flutter (AF) associated with stroke. We hypothesized that introduction and termination of anticoagulation based upon AT monitoring would reduce both stroke bleeding. randomized 2718 patients dual-chamber biventricular defibrillators to start stop on remote rhythm vs. usual office-based follow-up determined standard clinical criteria. The primary analysis compared the composite endpoint stroke,...
The Na+-Ca2+ exchanger is an important regulator of cellular Ca2+ levels, and one isoform this transporter, NCX1, has been cloned previously (Nicoll, D. A, Longoni, S., Philipson, K
Using highly purified sarcolemmal vesicles isolated from dog ventricles, we examined the effects of pH on Na+-Ca2+ exchange. The initial rate Nai+-dependent Ca2+ uptake is a sigmoid function pH. inhibited at 6 and stimulated 9 (as compared with 7.4). This dependence suggests that ionization state histidine residue may be important in H+ are partially competitive Ca2+, although this relationship complex. Nao+-dependent efflux also sensitive to increases monotonically These appear due...
The current cardiac pacemakers are battery dependent, and the pacing leads prone to introduce valve damage infection, plus a complete pacemaker retrieval is needed for replacement. Despite reported wireless bioelectronics pace epicardium, open-chest surgery (thoracotomy) required implant device, procedure invasive, requiring prolonged wound healing health care burden. We hereby demonstrate fully biocompatible microelectronics with self-assembled design that can be rolled into lightweight...
We have investigated alterations in sarcolemmal function that occur during myocardial ischemia. Rabbit ventricles were incubated at 37 degrees C for time periods ranging from 5 min to 2 h. The ischemic tissue was homogenized, and activities of the enzymes Na+-K+-ATPase, K+-p-nitrophenylphosphatase (K+-pNPPase), adenylate cyclase measured crude homogenate. Na+-K+-ATPase K+-pNPPase substantially inhibited after only 10 ischemia, all three declined progressively up 1 h when 37-59% control....
We studied the performance of ventricular muscle and cardiac function hearts from rats conditioned by swimming (CH) sedentary (SH) in an isolated working heart apparatus modified to measure end-diastolic volume dye dilution. Instantaneous aortic flow, left (LV) pressure oxygen consumption were measured. Heart rate mean kept constant, atrial filling was varied 5 20 cm H2O. weights SH CH equal pressures volumes similar at all pressures. However, ejection fraction, calculated circumferential...
Abstract Pacemakers have existed for decades as a means to restore cardiac electrical rhythms. However, lead-related complications remained clinical challenge. While market-released leadless devices addressed some of the issues, their pacer-integrated batteries cause new health risks and functional limitations. Inductive power transfer enables wireless powering bioelectronic devices; however, Specific Absorption Rate size limitations reduce efficiency biomedical applications. We designed...
Understanding the regenerative capacity of small vertebrate models has provided new insights into plasticity injured myocardium. Here, we demonstrate application flexible microelectrode arrays (MEAs) in elucidating electrophysiological phenotypes zebrafish and neonatal mouse heart regeneration. The 4-electrode MEA membranes were designed to detect electrical signals aquatic environment. They micro-fabricated adhere non-planar body surface mice. acquired processed display an electrocardiogram...
BackgroundThe utility of defibrillation threshold testing in patients undergoing implantable cardioverter -defibrillator (ICD) implantation is controversial.Higher thresholds have been noted cardiac resynchronization therapy defibrillators (CRT-D).Since the risks and potential benefits may be higher this population, we sought to assess impact safety margin or vulnerability CRT-D recipients. Methods resultsA total 256 consecutive subjects who underwent between January 2003 December 2007 were...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIdentification of Peroxy Radicals by Electron Paramagnetic ResonanceMalcolm. Bersohn and J. R. ThomasCite this: Am. Chem. Soc. 1964, 86, 5, 959Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/ja01059a068https://doi.org/10.1021/ja01059a068research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations30LEARN ABOUT THESE...
A new gamma-labeled marker for extracellular space is the cobaltic form of 58Co-ethylenediaminetetraacetic acid (58Co-EDTA). The ion has a much higher affinity EDTA than cobaltous ion; it prepared as potassium salt, K+(58Co3+-EDTA4-), and apparently biologically inert. Testing by equilibration in intact rabbits comparing myocardial content with that [14C]sucrose give values volume distribution myocardium 0.294 +/- 0.052 ml/g 58Co-EDTA 0.303 0.051 (SD, n = 130, two hearts), ratios...
Implantable cardioverter-defibrillators (ICDs) for primary prevention became standard of care after the publication second Multicenter Automatic Defibrillator Implantation Trial (MADIT-II) and Sudden Cardiac Death in Heart Failure (SCD-HeFT).To determine percentage patients a Veterans Affairs medical center appropriately referred prophylaxis ICD to further categorize reasons are not being referred.Echocardiograms obtained since release MADIT-II 2002 were searched left ventricular ejection...
Abstract The first computer program that plans multi-step organic syntheses has been written. In the course of its operation generates partially complete synthetic pathways and ranks them as to efficiency. At each stage develops route which it judges be most efficient, extends by one step. Partially routes lose too much material are discarded. After tolerably efficient pathway from available starting materials goal molecule is completed, entire printed, together with yield step overall yield.
Radiofrequency ablation is first-line therapy for atrial flutter (AFL). There are no studies of in patients with severe pulmonary arterial hypertension (PAH).Consecutive PAH (systolic artery pressure >60 mmHg) and AFL referred were evaluated. Patients complex congenital heart disease excluded.A total 14 procedures undertaken 12 patients. A 75% female; mean age 49 ± years. SPAP prior to was 99 35 mmHg. Baseline 6-minute walk distance 295 118 m. ECG demonstrated a typical pattern only 42%...
The stability constant of L-histidine-Cu(II)-L-threonine relative to Cu(II)-L-histidine and Cu(II)-L-threonine has been determined. absorption maxima were shown be at 645 mμ 625 respectively a solution containing mixture L-histidine, Cu(II), L-threonine in 1:1:1 molar ratio shows an maximum 615 mμ. Shifts spectra changes the optical density observed when concentration ligands was changed. rotatory dispersion studies reveal that, region 640–700 mμ, it is especially apparent that rotation...