A5038366927- EEG and Brain-Computer Interfaces
- Congenital heart defects research
- ECG Monitoring and Analysis
- Analytical Chemistry and Sensors
- Neuroscience and Neural Engineering
- Non-Invasive Vital Sign Monitoring
- Blind Source Separation Techniques
- Electrochemical Analysis and Applications
- Heart Rate Variability and Autonomic Control
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Wireless Power Transfer Systems
- Zebrafish Biomedical Research Applications
- Neonatal and fetal brain pathology
- Energy Harvesting in Wireless Networks
- Wireless Body Area Networks
- Gas Sensing Nanomaterials and Sensors
- Neuroscience and Neuropharmacology Research
- Cardiomyopathy and Myosin Studies
- Advanced Sensor and Energy Harvesting Materials
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Biosensors and Analytical Detection
- Acoustic Wave Resonator Technologies
- Advanced Chemical Sensor Technologies
University of California, Irvine
2017-2025
National University of Defense Technology
2025
UC Irvine Health
2019-2024
University of Washington Bothell
2015-2022
Shahid Beheshti University
2022
Irvine University
2019-2022
Samueli Institute
2019-2021
University of California System
2021
Institute of Population, Health and Development
2019
California Institute for Regenerative Medicine
2018
In this study, a device for gastroesophageal reflux disease (GERD) monitoring has been prototyped. The system consists of an implantable, batteryless and wireless transponder with integrated impedance pH sensors; wearable, external reader that wirelessly powers up the interprets transponded radio-frequency signals. implant total size 0.4 cm ×0.8 ×3.8 harvests radio frequency energy to operate dual-sensor load-modulation circuitry. can store data in memory card and/or send it base station...
In this letter, we developed an integrated neural probe prototype for optogenetic stimulation by microscale light-emitting diode (μLED) and simultaneous recording of activities with microelectrodes on a single-polyimide platform. Optogenetics stimulates in vivo circuits high-cellular specificity achieved genetic targeting precise temporal resolution interaction light-gated ion channels optical beam. our newly optrode probe, during neurons, continuous sensing neuronal vicinity the activation...
Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS) pressure gradients (∇P) across atrioventricular (AV) canal. Zebrafish (Danio rerio) are a genetically tractable system to investigate cardiac morphogenesis. The use Tg(fli1a:EGFP)y1 transgenic embryos allowed for delineation two-dimensional reconstruction endocardium. This time-varying motion was then prescribed in moving domain computational fluid dynamics (CFD) model, providing...
Fluid shear stress intimately regulates vasculogenesis and endothelial homeostasis. The canonical Wnt/β-catenin signaling pathways play an important role in differentiation proliferation. In this study, we investigated whether activated angiopoietin-2 (Ang-2) via the Wnt pathway with implication vascular repair.Oscillatory upregulated both TOPflash reporter activities expression of Ang-2 mRNA protein human aortic cells accompanied by increase nuclear β-catenin intensity. Oscillatory...
Monitoring of structural health plays a crucial role in condition-based maintenance and degradation prediction infrastructures. In this paper, we developed novel interdigitated capacitive (IDC) strain sensor which could be integrated wireless monitoring system for (SHM) applications. The IDC sensors were fabricated by laser-micromachining 127-μm-thick brass sheet followed encapsulation deformable thermoset polymers. was implemented using commercial module (eZ430-RF2500 from Texas...
Traditional herbal medicine has been an inseparable part of the traditional medical science in many countries throughout history. Nowadays, popularity using medicines daily life, as well clinical practices, gradually expanded to numerous Western with positive impacts and acceptance. The continuous growth consumption market promoted standardization modernization herbal-derived products present pharmacological criteria. To store extensively share this knowledge community serve scientific...
Abstract Biomimetic scaffolds that replicate the native architecture and mechanical properties of target tissues have been recently shown to be a very promising strategy guide cellular growth facilitate tissue regeneration. In this study, porous, soft, elastic crosslinked urethane‐doped polyester (CUPE) engineered nerve guides were fabricated with multiple longitudinally oriented channels an external non‐porous sheath mimic endoneurial microtubular epineurium structure, respectively. The...
Understanding the regenerative capacity of small vertebrate models has provided new insights into plasticity injured myocardium. Here, we demonstrate application flexible microelectrode arrays (MEAs) in elucidating electrophysiological phenotypes zebrafish and neonatal mouse heart regeneration. The 4-electrode MEA membranes were designed to detect electrical signals aquatic environment. They micro-fabricated adhere non-planar body surface mice. acquired processed display an electrocardiogram...
The invasive method of fetal electrocardiogram (fECG) monitoring is widely used with electrodes directly attached to the scalp. There are potential risks such as infection and, thus, it usually carried out during labor in rare cases. Recent advances electronics and technologies have enabled fECG from early stages pregnancy through extraction combined fetal/maternal ECG (f/mECG) signal recorded non-invasively abdominal area mother. However, cumbersome algorithms that require reference...
Electrocardiogram (ECG) is routinely used to identify key cardiac events such as changes in ECG intervals (PR, ST, QT, etc.), well capture critical vital signs heart rate (HR) and variability (HRV). The gold standard requires clinical measurement, limiting the ability everyday settings. Photoplethysmography (PPG) offers an out-of-clinic alternative for non-invasive, low-cost optical of physiological measurement settings, increasingly health monitoring many commercial wearable devices....
Iridium oxide pH sensing film is demonstrated with wide pH-sensing ranges, high durability, and small drifts in potentials. Using sol-gel process, a lower fabrication cost less labor-intensive method, to deposit iridium thin films for reported previously by our group expected advantages. In this paper, we fabricate test characteristics of 4 × anhydrous thin-film electrode arrays on flexible substrates. The sensors exhibit Nernstian potential responses the range 57.0-63.4 mV/pH. Stability,...
Due to the global hypertension epidemic, a convenient, miniaturized, and cuff-less blood pressure (BP) monitoring device is desirable. During past several years, we have attested various studies acquire BP indirectly via pulse transit time (PTT) obtained from electrocardiogram (ECG) photoplethysmogram (PPG). Towards this end, some progress has been achieved but prospect of designing that requires neither cuff nor cross-body contact ECG electrodes uncharted. In paper, present two approaches...
Flexible iridium oxide (IrOx)-based micro-electrodes were fabricated on flexible polyimide substrates using a sol-gel deposition process for utilization as integrated pseudo-reference electrodes bio-electrochemical sensing applications. The fabrication method yields reliable miniature on-probe IrOx with long lifetime, high stability and repeatability. Such sensors can be used long-term measurements. Various dimensions of including 1 mm × mm, 500 µm µm, 100 fabricated. Sensor longevity pH...
Monitoring of fetal electrocardiogram (fECG) would provide useful information about wellbeing as well any abnormal development during pregnancy. Recent advances in flexible electronics and wearable technologies have enabled compact devices to acquire personal physiological signals the home setting, including those expectant mothers. However, high noise level daily life renders long-entrenched challenges extract fECG from combined fetal/maternal ECG signal recorded abdominal area mother....
Due to the difficulties and complications in quantitative assessment of traumatic brain injury (TBI) its increasing relevance today’s world, robust detection TBI has become more significant than ever. In this work, we investigate several machine learning approaches assess their performance classifying electroencephalogram (EEG) data a mouse model. Algorithms such as decision trees (DT), random forest (RF), neural network (NN), support vector (SVM), K-nearest neighbors (KNN) convolutional...
Traumatic Brain Injury (TBI) is a common cause of death and disability. However, existing tools for TBI diagnosis are either subjective or require extensive clinical setup expertise. The increasing affordability reduction in the size relatively high-performance computing systems combined with promising results from related machine learning research make it possible to create compact portable early detection TBI. This work describes Raspberry Pi based portable, real-time data acquisition,...
Detection of bacterial pathogens is significant in the fields food safety, medicine, and public health, just to name a few. If are not properly identified treated promptly, they can lead morbidity mortality, also possibly contribute antimicrobial resistance. Current detection methodologies rely solely on laboratory-based techniques, which limited by long turnaround times, expensive costs, risks inadequate accuracy; also, work requires trained specialists. Here, we describe cost-effective...