A5087790536- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Elasticity and Material Modeling
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Health and Disease Prevention
- Advanced Numerical Methods in Computational Mathematics
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- Advanced MRI Techniques and Applications
- Kawasaki Disease and Coronary Complications
- Hemodynamic Monitoring and Therapy
- Probabilistic and Robust Engineering Design
- Cardiac and Coronary Surgery Techniques
- Congenital heart defects research
- Model Reduction and Neural Networks
- Cardiovascular Issues in Pregnancy
- Tissue Engineering and Regenerative Medicine
- Advanced Mathematical Modeling in Engineering
- Electrospun Nanofibers in Biomedical Applications
Cardiovascular Institute of the South
2022-2025
Stanford University
2016-2025
Stanford Medicine
2016-2024
La Jolla Bioengineering Institute
2024
Palo Alto University
2016-2024
University of Michigan
2024
Bioengineering Center
2023
Ofcom
2023
Massachusetts General Hospital
2019
Lucile Packard Children's Hospital
2018
Abstract
Simulations of blood flow in both healthy and diseased vascular models can be used to compute a range hemodynamic parameters including velocities, time varying wall shear stress, pressure drops, energy losses. The confidence the data output from cardiovascular simulations depends directly on our level certainty simulation input parameters. In this work, we develop general set tools evaluate sensitivity uncertainties simulations. Uncertainties arise boundary conditions, geometrical...
Stimulated by a recent controversy regarding pressure drops predicted in giant aneurysm with proximal stenosis, the present study sought to assess variability prediction of pressures and flow wide variety research groups. In phase I, lumen geometry, rates, fluid properties were specified, leaving each group choose their solver, discretization, solution strategies. Variability was assessed having interpolate results onto standardized mesh centerline. For II, physical model geometry...
This paper provides a review of the space–time (ST) and Arbitrary Lagrangian–Eulerian (ALE) techniques developed by first three authors' research teams for patient-specific cardiovascular fluid mechanics modeling, including fluid–structure interaction (FSI). The core methods are ALE-based variational multiscale (ALE-VMS) method, Deforming-Spatial-Domain/Stabilized ST formulation, stabilized FSI technique. A good number special targeting have been to be used with methods. These include: (i)...
Coronary stent design affects the spatial distribution of wall shear stress (WSS), which can influence progression endothelialization, neointimal hyperplasia, and restenosis. Previous computational fluid dynamics (CFD) studies have only examined a small number possible geometries to identify designs that reduce alterations in near-wall hemodynamics. Based on previously described framework for optimizing cardiovascular geometries, we developed methodology couples CFD three-dimensional...
Image-based computational fluid dynamics (CFD) is widely used to predict intracranial aneurysm wall shear stress (WSS), particularly with the goal of improving rupture risk assessment. Nevertheless, concern has been expressed over variability predicted WSS and inconsistent associations rupture. Previous challenges, studies from individual groups, have focused on aspects image-based CFD pipeline. The aim this Challenge was quantify total whole 3D rotational angiography image volumes five...
Patient-specific simulation plays an important role in cardiovascular disease research, diagnosis, surgical planning and medical device design, as well education biomechanics. simvascular is open-source software package encompassing entire modeling pipeline from image segmentation, three-dimensional (3D) solid modeling, mesh generation, to patient-specific analysis. SimVascular widely used for basic science clinical research education, following increased adoption by users development of a...
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of U.S. Food Drug Administration (FDA)-approved clinical trial evaluating this patients with single-ventricle cardiac anomalies. The TEVG was used as Fontan conduit to connect the inferior vena cava pulmonary artery, but high incidence narrowing manifested within first 6 months, which treated successfully angioplasty. To elucidate mechanisms underlying early stenosis, we data-informed,...
Three-dimensional (3D) cardiovascular fluid dynamics simulations typically require hours to days of computing time on a high-performance cluster. One-dimensional (1D) and lumped-parameter zero-dimensional (0D) models show great promise for accurately predicting blood bulk flow pressure waveforms with only fraction the cost. They can also accelerate uncertainty quantification, optimization, design parameterization studies. Despite several prior studies generating 1D 0D comparing them 3D...