A5008051879- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gallbladder and Bile Duct Disorders
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Innovations in Medical Education
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Eosinophilic Esophagitis
- Bioinformatics and Genomic Networks
Queen Mary Hospital
2010-2023
University of Hong Kong
2014-2023
Chinese University of Hong Kong
2003-2023
Stanford University
1989-2013
Tri-Service General Hospital
1992-2011
Fox Chase Cancer Center
2010
The University of Texas MD Anderson Cancer Center
2010
University of Nevada, Reno
2010
Las Vegas Institute
2010
Cancer Care Ontario
2009
The role of gastric acid suppression in preventing the recurrence ulcer complications after eradication Helicobacter pylori infection patients taking long-term low-dose aspirin is uncertain.We enrolled 123 who had using continuously for more than one month and H. infection. After ulcers healed was eradicated, were randomly assigned to treatment with 30 mg lansoprazole daily or placebo, addition 100 daily, 12 months. primary end point complications.During a median follow-up months, 9 61...
Resection of hepatocellular carcinoma is associated with high rates morbidity and mortality. Since intensive nutritional support can reduce the catabolic response improve protein synthesis liver regeneration, we performed a prospective study to investigate whether perioperative could outcome in patients undergoing hepatectomy for carcinoma.
Objective The authors summarize the results of patients who had hepatectomy for hepatocellular carcinoma over a 22-year period. Summary Background Data Recent reports showed improved perioperative and long-term prognosis. Methods outcome 343 was studied according to three different time periods: before 1987 (n = 149); 1991 128); 1992 present 66). Survival analysis made by stratifying into two categories–either or after 1987. majority large tumors (78%). cirrhosis (73%), major (73%). Results...
This study aimed at: (1) documenting the evolution of surgical results esophagectomy in a high-volume center, (2) identifying predictive factors pulmonary complications and mortality, (3) examining whether preoperative chemoradiation therapy would complicate postoperative recovery.Pulmonary mortality rate after remain substantial, responsible have not been adequately studied. Neoadjuvant is widely used; it hypothesized that this may lead to adverse outcome.Prospectively collected data were...
We previously showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer detection. Here, we aimed to develop specific blood-based miRNA assay breast detection.TaqMan-based profiling was performed tumor, adjacent non-tumor, corresponding from patients, and matched healthy controls. All putative markers identified were verified a training set of patients. Selected validated case-control cohort 170 100 controls, 95 other types cancers then blindly an independent 70...
Abstract Background Educational pedagogies were modified during the COVID-19 pandemic to minimise interruption teaching. One approach has been distance learning problem-based (PBL) tutorial utilising online peer-to-peer platform. The aim of this study was compare performance students using PBL tutorials with that conventional face-to-face approach. Methods This retrospective conducted in a single academic institution. We compared two groups fourth-year medical from same class: one group used...
Gastric cancer is the world's second most common cause of death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic and 22 nonneoplastic tissues, using cDNA microarrays representing approximately 30,300 genes. cancers were distinguished from tissues by characteristic differences their patterns. found a diversity cancer, reflecting variation intrinsic properties tumor normal cells cellular composition these complex tissues. identified several genes whose levels...
Objective The objective of this study was to compare the hand-sewn and stapled methods in esophagogastric anastomosis. Summary Background Data After esophageal resection for cancer, relative merits anastomosis, especially regarding leakage stricture rates, have not adequately been studied. Methods A prospective randomized controlled trial undertaken 122 patients with squamous cell cancer thoracic esophagus who underwent a Lewis-Tanner esophagectomy. Patients were stratified according size,...
Activation of the phosphatidylinositol 3-kinase (PI3K) through mutational inactivation PTEN tumour suppressor gene is common in diverse cancer types, but rarely reported gastric cancer. Recently, mutations PIK3CA, which encodes p110α catalytic subunit PI3K, have been identified various human cancers, including 3 12 cancers. Eighty percent these clustered within 2 regions involving helical and kinase domains. In vitro study on one "hot-spot" mutants has demonstrated it as an activating...
Abstract The role of bacteria other than Helicobacter pylori (HP) in the stomach remains elusive. We characterized gastric microbiota individuals with different histological stages carcinogenesis and after receiving HP eradication therapy. Endoscopic biopsies were obtained from subjects gastritis, intestinal metaplasia (IM), cancer (GC) negative controls. Gastric was by Illumina MiSeq platform targeting 16 S rDNA. Apart dominant H. , we observed Proteobacteria including Haemophilus,...
Cigarette smoke is one of the risk factors for gastric cancer and nicotine has been reported to promote tumor growth. Deregulation microRNA (miRNA) cyclooxygenase-2 (COX-2) expressions are hallmarks many cancers including cancer. Here, we used an miRNA array platform covering a panel 95 human miRNAs examine expression profile in nicotine-treated cells. We found that miR-16 miR-21 were upregulated upon stimulation, transfection with anti-miR-16 or anti-miR-21 significantly abrogated cell...
Despite the declining incidence of gastric cancer, mortality rate remains high due to late presentation. We aimed evaluate sensitivity miRNA as a diagnostic marker for cancer in circulation.Plasma samples from 3 independent groups comprise 123 patients and 111 healthy controls profiling microarray screening.Microarray data showed that 25 miRNAs were upregulated 6 highly expressed (miR-18a, miR-140-5p, miR-199a-3p, miR-627, miR-629 miR-652) selected validation. In an validation set, levels...
We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a previously implicated as modifier the Apc Min/+ (multiple intestinal neoplasia 1) mutant phenotype mouse, was significantly correlated with patient survival. confirmed this observation an independent set samples quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, result suggests intriguing possibility that activity PLA2G2A...
In Brief Objective To identify prognostic factors and reasons for improved survival over time in patients with esophageal cancer. Summary Background Data Management strategies cancer have evolved time. The impact of chemoradiation the overall treatment results has not been adequately studied. Methods From 1990 to 2000, 399 (62.4%) 639 intrathoracic squamous cancers underwent resection. Two study periods were analyzed: period I (01/1990–06/1995), II (07/1995–12/2000); during II, was...