A5102723417- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Reproductive System and Pregnancy
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cardiac Arrest and Resuscitation
- Diabetes and associated disorders
- Poisoning and overdose treatments
- Heart Failure Treatment and Management
- IL-33, ST2, and ILC Pathways
- Renal and Vascular Pathologies
- Trauma Management and Diagnosis
- Prostate Cancer Treatment and Research
- Inflammasome and immune disorders
- Autopsy Techniques and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traditional Chinese Medicine Analysis
Guangdong Academy of Medical Sciences
2015-2025
Guangdong Provincial People's Hospital
2019-2025
Southern Medical University
2020-2025
Shanghai Medical College of Fudan University
2020
Guangdong General Hospital
2015-2019
Peking University First Hospital
2017
Peking University
2017
King University
2017
Longgang Central Hospital
2012
Sun Yat-sen University
2009
Recent studies have revealed that alternatively activated macrophages (AAMs) are involved in tumor progression. However, the effect of AAMs on metastasis prostate cancer is poorly understood. In present study, tissues 42 patients with adenocarcinoma (PCa) were used analysis associated (TAMs) and by immunofluorescence. The followed up for 5 years. associations TAMs clinicopathological features outcome these cases evaluated. Immunofluorescent indicated mean number (CD68-positive cells) PCa...
Objectives: The role of M2 macrophages in the pathogenesis and progression primary membranous nephropathy (PMN) remains unknown. In this study, we aimed to investigate relationship between subsets clinicopathological features patients with PMN. Methods: A total 55 PMN confirmed by biopsy were recruited. clinical pathological data recorded, respectively. Immunohistochemistry was used detect markers macrophages, including (CD68+), M2a (CD206+), M2b (CD86+) M2c (CD163+). Results: numbers...
Club cell secretory protein 16 (CC16) has protective roles in airway diseases, including anti-inflammatory, immunomodulatory, and antioxidant functions. This study investigates CC16's potential to repair lung injury from particulate matter 2.5 (PM2.5) exposure asthmatic mice. In an ovalbumin (OVA)-induced asthma model, 6-week-old male C57BL/6J mice were exposed PM2.5 for 24 hours then treated with CC16. We conducted arterial blood gas analysis, function tests, histopathology,...
The kidney is one of the organs most frequently affected in immunoglobulin G4-related disease (IgG4-RD). Early identification IgG4-RD with renal injury by clinical features a current challenge. There paucity data regarding involvement IgG4-RD. Patients diagnosis and without were included retrospective cohort study. Cox regression analyses used to investigate risk factors for relapse construct nomogram model. From December 2014 February 2022, 54 patients retrospectively enrolled. Renal was...
Abstract Background The accuracy of the estimated glomerular filter rate (eGFR) in elderly patients is debatable. In 2020, a new creatinine-based equation by European Kidney Function Consortium (EKFC) was applied to all age groups. objective this study assess appropriateness EKFC with Chronic Disease Epidemiology Collaboration (CKD-EPI), Lund-Malmö Revised (LMR), Berlin Initiative Study 1 (BIS1), and full spectrum (FAS) equations based on serum creatinine (SCR) for Chinese patients. Methods...
<b><i>Background/Aims</i></b>: Cardiorenal syndrome type 1 (CRS1) is a characterized by rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims this study were investigate the risk factors and prognosis CRS1 in elderly patients. <b><i>Methods</i></b>: A total 312 patients (≥60 years old) with heart failure (AHF) studied. They assigned as (suffered from in-hospital AKI) or NCRS1 (without group. Clinical laboratory data...
Long-term peritoneal dialysis (PD) is associated with the development of fibrosis (PF). Understanding changes immune environments and mesothelial cells (PMCs) may lead to discovery mechanisms PF. Therefore, we used single-cell RNA sequencing interrogate cell composition transcriptome characteristics in dialysate continuous ambulatory PD (CAPD) patients at different stages. Results showed that six major populations were identified overnight effluent dialysate. Two subsets macrophages...
Aim: Loss of renal function is associated with immune deficiency; however, few studies have addressed the role B lymphocytes in elderly patients chronic kidney disease (CKD). In this study, we examined distribution and relationship lymphocyte subpopulation clinical outcomes CKD patients. Methods: a total 380 (312 64 non-CKD controls) were recruited. Venous blood samples analysed by flow cytometry to determine following cell subsets: cells (CD19+), innate B1 (CD19+CD5+) conventional B2...
Glucose is the primary osmotic medium used in most peritoneal dialysis (PD) solutions, and long‑term exposure to high glucose a major contributor fibrosis. Our previous study revealed that M2 macrophages participate development of PD‑related fibrosis rat model. In present study, effects on macrophage polarization vivo vitro were further evaluated. Continuous ambulatory PD (CAPD) patients with an overnight dwell 1.5 or 2.5% dialysate recruited for this study. Overnight effluent samples from...
Abstract Purpose The purpose of this study was to develop a functional clinical nomogram for predicting 8-year overall survival (OS) patients with prostate cancer (PCa) primary based on peripheral lymphocyte. Patients and methods Using data from single-institutional registry 94 PCa in China, identified integrated significant prognostic factors build nomogram. discriminative ability measured by concordance index (C-index) ROC curves (Receiver Operating Characteristic Curves). And the...
Abstract Background The interaction of dysbiosis gut microbiota (GM) with diabetic nephropathy (DN) drew our attention and a better understanding GM on DN might provide potential therapeutic approaches. However, the exact causal effect remains unknown. Methods We applied two-sample Mendelian Randomization (MR) analysis, including inverse variance weighted (IVW), MR-Egger methods, etc., to screen significant bacterial taxa based GWAS data. Sensitivity analysis was conducted assess robustness...
Background: Few epidemiologic studies on acute kidney injury (AKI) have focused the older adult population. This study investigated clinical features, risk factors, and burden in this population.Methods: A retrospective observational was performed with data of inpatients at Guangdong Geriatrics Institute from 1 August 2012, to 31 December 2016. AKI classified into community-acquired (CA-AKI) hospital-acquired (HA-AKI), factors for were ranked by weight. The relationships between adverse...
Chronic kidney disease accounts for much of the increased mortality, especially in elder population. The prevalence this is expected to increase significantly as society ages. Our aim was evaluate function and risk factors reduced renal among elderly Chinese patients. This study retrospectively collected clinical data from a total 1062 inpatients aged 65 years or over. Estimated glomerular filtration rate (eGFR) calculated with Kidney Disease Epidemiology Collaboration (CKD-EPI) equation....
Transmitted drug resistance (TDR) increases the risk of antiretroviral therapy (ART) failure in HIV-1 patients. This study investigated molecular epidemiology TDR and its transmission networks among newly diagnosed patients Wenzhou, China.
Aim The aim of the present study was to investigate predominant pathogens and predictors 28‐day mortality older Chinese patients with nosocomial urinary tract infections (NUTI). Methods We retrospectively studied 1122 (aged ≥60 years) culture‐positive NUTI in Guangdong General Hospital, Guangzhou, China, from January 2009 December 2014. clinical features, microbial distributions outcomes these were recorded compared between survival death patients. Multivariate logistic regression carried...
Introduction: The clinicopathologic characteristics of Hepatitis B virus-associated glomerulonephritis (HBV-GN) patients with different serum HBsAg are not well known. This study aims to investigate the and treatments between HBV-GN positive negative HBsAg. Methods: A retrospective review renal biopsies in Guangdong Provincial People’s Hospital from 2005 2018 was performed. Clinicopathological data, remission proteinuria were collected compared HBsAg+ HBsAg- group. Results: total 101...
Purpose: Acute kidney injury (AKI) is a major health problem with poor prognosis.However, little known about elderly community-acquired-AKI (CA-AKI).This study aimed to investigate the incidence, clinical characteristics, outcomes and use of suspected nephrotoxic medications after CA-AKI in elderly.Materials Methods: A total 36,445 patients aged over 60 years were recruited from 2013 2016.Through an electronic database, we collected demographic medical history data, admission lab results all...
Idiopathic membranous nephropathy (IMN) is the leading cause of nephrotic syndrome in elderly. The treatment idiopathic quite challenging due to particularity elderly patients. This study intends investigate clinicopathological characteristics and initial therapeutic effect among patients.A retrospective 67 patients (58.2% male, median age 69.0 years, range, 65-83 years) with biopsy-proven was conducted at Guangdong Provincial People's Hospital from 2016 2020. Data on effects were...