A5101725466- Platelet Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Ophthalmology and Visual Impairment Studies
- Thyroid Disorders and Treatments
- Corneal surgery and disorders
- Circadian rhythm and melatonin
- Traditional Chinese Medicine Studies
- Heart Rate Variability and Autonomic Control
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- COVID-19 Clinical Research Studies
- Genetics, Aging, and Longevity in Model Organisms
- Cardiovascular Disease and Adiposity
- Vascular Tumors and Angiosarcomas
- Birth, Development, and Health
- Ocular Surface and Contact Lens
- Esophageal Cancer Research and Treatment
- Phytochemistry and Biological Activities
- Chronic Lymphocytic Leukemia Research
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Dietary Effects on Health
- Complementary and Alternative Medicine Studies
- Metabolism, Diabetes, and Cancer
First Affiliated Hospital of Jinan University
2025
Jiangsu University
2023-2025
Affiliated Hospital of Jiangsu University
2023-2025
Army Medical College
2025
Army Medical University
2025
Guangzhou University of Chinese Medicine
2020-2024
Zhejiang Cancer Hospital
2024
Guangdong Academy of Medical Sciences
2020-2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Epithelial ovarian cancer (EOC) is a deadly disease with limited diagnostic biomarkers and therapeutic targets. Here we conduct comprehensive proteomic profiling of tissue plasma samples from 813 patients different histotypes regimens, covering the expression 10,715 proteins. We identify eight proteins associated tumor malignancy in specimens, which are further validated as potential circulating plasma. Targeted proteomics assays developed for 12 7 blood proteins, machine learning models...
The timing of meals has been suggested to play an important role in circadian regulation and metabolic health. Three a day is well-established human feeding habit, which today's lifestyle may or not be followed. aim this study was test whether the absence breakfast supper significantly affects system physiological function. authors developed rat model for their daily three study, whereby animals were divided into groups (three meals, TM; no first meal, NF; last NL) all fed with same amount...
Abstract Background This study aimed to compare the changes in axial length (AL) myopic children that wear centered and decentered orthokeratology (Ortho-K). Methods retrospective included 217 subjects who were treated with an Ortho-K lens for >12 months. The divided into three groups based on magnitude of treatment zone decentration: mildly, moderately, severely groups. Distance direction decentration calculated using software was developed in-house. AL different compared. Results Based...
Background: Lactate dehydrogenase (LDH) has been proved to be a prognostic factor for the severity and poor outcomes of coronavirus disease 2019 (COVID-19). In most studies, patients with various levels COVID-19 were pooled analyzed which may prevent accurate evaluation relationship between LDH progression in-hospital death. this study, we aimed evaluate association mortality in severe critically ill COVID-19. Methods: This single-center retrospective study enrolled 119 patients. Survival...
Nocturnal variations in blood pressure (BP) were associated with carotid intima-media thickness. However, the precise relationship between circadian of BP and plaques remains unknown. Therefore, prognostic value reverse-dipper pattern for plaque was investigated. In this cross-sectional study, a total 524 hypertensive patients recruited evaluated ambulatory monitoring April 2012 June 2013. Carotid classified into Grade 0 (normal or no observable plaque), 1 (mild stenosis, 1%–24% narrowing),...
Abstract Recent studies suggested that nocturnal variations of blood pressure (BP) were closely related to type 2 diabetes. However, little information has been revealed about the relationship between reverse-dipper pattern BP and In this cross-sectional study, 531 hypertensive patients evaluated with ambulatory monitoring (ABPM). Diagnosis diabetes in Chinese adults was made according diagnostic criteria 2015. Multivariate logistic regression used examine relationships ABPM results. (32.3%)...
Type 2 diabetic kidney disease is the most common cause of chronic diseases (CKD) and end-stage renal (ESRD). Although biopsy considered as 'gold standard' for (DKD) diagnosis, it an invasive procedure, diagnosis can be influenced by sampling bias personal judgement. It desirable to establish a non-invasive procedure that complement in tracking DKD progress.In this cross-sectional study, we collected 252 urine samples, including 134 uncomplicated diabetes, 65 DKD, 40 CKD without diabetes 13...
/Purpose: Cuproptosis may play a significant role in breast cancer (BC). We aimed to investigate the prognostic impact of cuproptosis-related lncRNAs BC. Consensus clustering analysis categorized TCGA-BRCA samples into 3 clusters, followed by survival and immune analyses clusters. LASSO-COX was performed on differentially expressed BC construct model. Gene Ontology/Kyoto Encyclopedia Genes Genomes (GO/KEGG) enrichment, immune, drug prediction were high-risk low-risk groups. Cell experiments...
Purposes. To evaluate the effects of thyroid peroxidase antibodies (TPOAb) on maternal and neonatal adverse outcomes in pregnant women. Methods. 208 women at 24–28 weeks were divided into two groups, TPOAb-positive TPOAb-negative groups. Thyroid function TPOAb determined all subjects until 12 months postpartum. Levothyroxine was supplemented to maintain euthyroid with periodical checking functions. The prevalence postpartum thyroiditis (PPT), placenta previa, placental abruption, premature...
Abstract Background Accurately identifying patients with axillary pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer remains challenging. Purpose To compare the feasibility of shear wave elastography (SWE) performed on tumors and lymph nodes (LNs) predicting status NAC. Materials Methods This prospective study included a total 319 biopsy-proven positive node who received NAC followed by dissection from 2019 to 2022. The correlations between velocity...
Abstract Background Modified Si-Miao granule (mSMG), a traditional Chinese medicine, is beneficial for T2DM and insulin resistance (IR), but the underlying mechanism remains unknown. Methods Using network pharmacology, we screened compounds of mSMG identified its targets pathway on hepatic IR in T2DM. molecular docking, affinity between hub target TNF-α. Then these were verified KK-Ay mice HepG2 cells. Results 50 170 against screened, 9 such as TNF MAPK8 identified. mainly enriched pathway,...
Esophageal cancer is a highly invasive malignancy. Neoadjuvant chemoradiotherapy not only increases the rate of complete resection but also improves median survival. However, sensitive biomarker urgently needed in clinical practice. 60 esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant (NCRT) were enrolled at People's Hospital Affiliated to Jiangsu University. Patients grouped according tumor regression grade (TRG) criteria from College American Pathologists (CAP). The...
Thyroid disease and gestational diabetes mellitus (GDM) are frequent complications during pregnancy. We observed the relationship between thyroid indicators blood glucose to analyze whether function is associated with development of GDM. enrolled a total 575 pregnant women diagnosed GDM 573 without The correlation levels was established through analysis. In addition, stratified analysis restricted cubic spline curves were employed describe association incidence found no significant...
Patients with early-onset preeclampsia (EOPE) have a most severe disease state. a2-macroglobulin (A2M) play crucial role in the pathogenesis of EOPE, but its molecular basis and therapeutic potential remain unclear. This study aimed to elucidate mechanisms A2M EOPE progression explore treatment EOPE. A2M-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) blocker Receptor-associated protein (RAP) were utilized alleviate symptom lipopolysaccharide (LPS) induced rat model. RNA-seq data...
<title>Abstract</title> To evaluate the efficacy, safety, and steroid-sparing effect of tofacitinib combined with corticosteroids (CS) in pemphigus treatment. Clinical data from moderate patients treated CS monotherapy or plus (CT) between June 2019 January 2024 were analyzed. The primary endpoint was complete remission (CR) rate at 1 year. Secondary endpoints comprised monthly number achieving Minimum therapeutic dose (CSmin) therapy, total annual cumulative doses, median relapse frequency,...
<sec> <title>BACKGROUND</title> Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of advanced esophageal squamous cell carcinoma (ESCC). However, response varies. </sec> <title>OBJECTIVE</title> This study investigates prognostic value dynamic lactate dehydrogenase (LDH) changes during ICI therapy in predicting outcomes. <title>METHODS</title> We retrospectively analyzed clinical data from 126 patients with ESCC treated first-line ICIs. Serum LDH levels were...
BACKGROUND Colorectal cancer (CRC) is among the most prevalent and deadly cancers globally, particularly in China. Treatment challenges remain advanced metastatic cases, especially third- fourth-line settings. The combination of targeted therapies with immune checkpoint inhibitors (ICIs) has shown potential addressing limitations single-agent treatments. AIM To evaluate efficacy safety therapy (TT) alone ICIs for CRC (mCRC). METHODS A multicenter retrospective observational study was...
Natural small-molecule phenols (NSMPs) share some bioactivities. The anxiolytic activity of NSMPs is attracting attention in the scientific community. This paper provides data supporting hypothesis that are generally anxiolytic. activities seven simple phenols, including phloroglucinol, eugenol, protocatechuic aldehyde, vanillin, thymol, ferulic acid, and caffeic were assayed with elevated plus maze (EPM) test mice. oral doses 5, 10 20 mg/kg, except for phloroglucinol which 2.5, 5 mg/kg. All...
Abstract Background Addressing presbyopia in the aging population, particularly non-cataractous patients, remains a challenge. This study evaluates outcomes of refractive lens exchange (RLE) with AT LISA tri 839MP trifocal intraocular (IOL) implantation Chinese presbyopic population without cataracts. Methods The included 164 eyes from 82 patients undergoing bilateral RLE at Peking Union Medical College Hospital. Comprehensive evaluations encompassed visual acuities, refraction, ocular...
The dipping variations of circadian blood pressure (BP) correlate closely with target-organ damages and cardiovascular events. aim this study was to investigate the relationship between BP reverse prevalence stable coronary artery disease (sCAD) in hypertensive patients. Clinical data results 24-hour ambulatory monitoring (ABPM) were obtained from 718 patients (390 males, mean age 59.6 ± 13.8 years) a single centre Northern China. Reverse pattern defined as nocturnal systolic (SBP) higher...