A5084462276- Biomarkers in Disease Mechanisms
- Hematological disorders and diagnostics
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Clusterin in disease pathology
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Vascular Tumors and Angiosarcomas
- Neutropenia and Cancer Infections
- Sleep and related disorders
- Silk-based biomaterials and applications
- Circadian rhythm and melatonin
- SARS-CoV-2 detection and testing
- Complement system in diseases
- Immune cells in cancer
- Radiopharmaceutical Chemistry and Applications
Guangdong Academy of Medical Sciences
2022-2025
Guangdong Provincial People's Hospital
2022-2025
Southern Medical University
2024-2025
South China University of Technology
2024-2025
Sun Yat-sen University
2022-2023
Xihua University
2023
Hunan First Normal University
2023
Bridge University
2022
Institute of Human Virology
2022
Xiamen University
2016-2019
Abstract Because of the rapid mutation and high airborne transmission SARS‐CoV‐2, a universal vaccine preventing infection in upper respiratory tract is particularly urgent. Here, mosaic receptor‐binding domain (RBD) nanoparticle (NP) developed, which induces more RBD‐targeted type IV neutralizing antibodies (NAbs) exhibits broad cross‐protective activity against multiple SARS‐CoV‐2 sublineages including newly‐emerged BF.7, BQ.1, XBB. As several T‐cell‐reactive epitopes, are highly conserved...
Abstract Growing evidence indicates that there is an emerging link between environmental pollution and cardiac hypertrophy, while the mechanism unclear. The objective of this study was to examine whether phenanthrene (Phe) could cause hypertrophy elucidate molecular mechanisms involved. We found that: 1) Phe exposure increased heart weight cardiomyocyte size rats; 2) led enlarged cell protein synthesis in H9C2 cells; 3) induced important markers such as atrial natriuretic peptide, B-type...
There is increasing recognition of the importance early-life environmental exposures in health disorders at later-life stages. The aim this study was to evaluate whether exposure benzo[a]pyrene (BaP) could induce neurodegenerative syndromes stages zebrafish. Embryos were exposed BaP doses 0, 0.05, 0.5, 5, and 50 nM from early embryogenesis 96 h post-fertilization (hpf), then transferred clean water maintained for 365 days. We found that decreased locomotor cognitive ability, neurotransmitter...
Influenza A virus (IAV) infection is a complicated process. After IAVs spread to the lung, extensive pro-inflammatory cytokines and chemokines are released, which largely determine outcome of infection. Using single-cell RNA sequencing (scRNA-seq) assay, we systematically sequentially analyzed transcriptome more than 16,000 immune cells in pulmonary tissue infected mice, demonstrated that two waves factors were released. group IAV-infected PD-L1+ neutrophils major contributor first wave at...
The SARS-CoV-2 Delta (B.1.617.2) strain is a variant of concern (VOC) that has become the dominant worldwide in 2021. Its transmission capacity approximately twice original strain, with shorter incubation period and higher viral load during infection. Importantly, breakthrough infections have continued to emerge first-generation vaccine recipients. There thus an urgent need develop novel variants as major target. Here, receptor binding domain (RBD)-conjugated nanoparticle vaccines targeting...
Abstract The success of immunotherapy for cancer treatment is limited by the presence an immunosuppressive tumor microenvironment (TME); Therefore, identifying novel targets to that can reverse this TME and enhance efficacy essential. In study, enrichment analysis based on publicly available single‐cell bulk RNA sequencing data from gastric patients are conducted, found tumor‐intrinsic interferon (IFN) plays a central role in regulation. results shows KDM3A over‐expression suppresses IFN...
Anoikis, a form of apoptotic cell death resulting from inadequate cell-matrix interactions, has been implicated in tumor progression by regulating angiogenesis and metastasis. However, the potential roles anoikis-related long non-coding RNAs (arlncRNAs) microenvironment are not well understood. In this study, five candidate lncRNAs were screened through least absolute shrinkage selection operator (LASSO), multivariate Cox regression analysis based on differentially expressed associated with...
Abstract Background: Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to be associated with the occurrence solid tumors, but its relationship colorectal cancer still needs studied. Methods: We conducted a prospective matched case-control study using data from UK Biobank, including 5,310 incident (CRC) cases and 26,550 controls for age, sex, body mass index (BMI). Results: Analysis Biobank revealed that presence CHIP was an increased risk CRC. The odds ratio (OR) CRC in...
<div>AbstractBackground:<p>Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to be associated with the occurrence solid tumors, but its relationship colorectal cancer still needs studied.</p>Methods:<p>We conducted a prospective matched case–control study using data from UK Biobank, including 5,310 incident cases and 26,550 controls for age, sex, body mass index.</p>Results:<p>Analysis Biobank revealed that presence CHIP was an...
<p>Supplementary Figure S1: Overview of the study design. Flowchart showing selection population.</p>
Abstract Acute myeloid leukemia (AML) is caused by clonal disorders of hematopoietic stem cells. Differentiation therapy emerging as an important treatment modality for leukemia, given its less toxicity and wider applicable population, but the arsenal differentiation-inducing agents still very limited. In this study, we adapted a competitive peptide phage display platform to search candidate peptides that could functionally induce human cell differentiation. A monoclonal (P6) corresponding...
ABSTRACT The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global pandemic, which severely endangers public health. Our and others’ works have shown that the angiotensin-converting enzyme (ACE2)-containing exosomes (ACE2-exos) superior antiviral efficacies, especially in response to emerging variants. However, mechanisms how virus counteracts host regulates ACE2-exos remain unclear. Here, we identified SARS-CoV-2 nonstructural protein 6 (NSP6)...
Abstract The prognosis of patients with peripheral T‐cell lymphoma (PTCL) depends on bone marrow involvement (BMI). (BM) tumor microenvironment in PTCL remains unclear. We performed single‐cell RNA sequencing (scRNA‐seq) 11 fresh BM samples from BMI to reveal the associations immune landscape and genetic variations patients. Compared not otherwise specified (NOS), angioimmunoblastic (AITL) had a higher number T cells, lower lymphocytes, greater inflammation. Immune heterogeneity AITL is...