A5101986769- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Microbial Community Ecology and Physiology
- Soil Carbon and Nitrogen Dynamics
- Pesticide and Herbicide Environmental Studies
- Ferroptosis and cancer prognosis
- Genetics, Aging, and Longevity in Model Organisms
- interferon and immune responses
- RNA modifications and cancer
- Toxic Organic Pollutants Impact
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant nutrient uptake and metabolism
- Plant and animal studies
- Circadian rhythm and melatonin
- Legume Nitrogen Fixing Symbiosis
- Ecology and Vegetation Dynamics Studies
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Plant Parasitism and Resistance
- Cancer-related gene regulation
- Microbial bioremediation and biosurfactants
- Traditional Chinese Medicine Analysis
- Nanoparticle-Based Drug Delivery
- Peroxisome Proliferator-Activated Receptors
- Curcumin's Biomedical Applications
Zhejiang Cancer Hospital
2024-2025
Chinese Academy of Sciences
2013-2025
Zhejiang University
2024
Zhejiang Hospital
2024
Shanghai First People's Hospital
2020-2024
Soochow University
2024
Zhangjiagang First People's Hospital
2024
Ministry of Agriculture and Rural Affairs
2023
Chinese Institute for Brain Research
2023
Institute of Biophysics
2022-2023
Abstract Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous viral proteins are subjected host-mediated post-translational modifications. Here, we demonstrate that SARS-CoV-2 nucleocapsid protein (SARS2-NP) is SUMOylated on lysine 65 residue, which efficiently mediates SARS2-NP’s ability in homo-oligomerization, RNA association, liquid-liquid phase separation (LLPS). Thereby innate antiviral immune...
Manure amendment generally bolsters soil organisms but not all bacteria equally. To understand why different taxa respond differently, we used shotgun metagenomic approaches to profile functional potentials and correlate them with taxon abundances. A originally unproductive was reclaimed using commercial manure finally became productive. The abundance of Firmicutes in the decreased, whereas that Bacteroidetes Proteobacteria increased after addition. Thirty-nine KEGG modules were...
Renal podocyte injury, apoptosis and autophagy are involved in the occurrence development of diabetic nephropathy (DN). Kaempferol (KPF) has promotion inhibition properties miscellaneous diseases, but these functions DN have not yet been elucidated.We used db/db mice to evaluate protective role KPF on DN. The anti-DN effect was evaluated by urine albumin-to-creatinine ratio pathological changes kidney tissue. Injury podocytes observed through Transmission electron microscopy....
Abstract Ferroptosis is recently discovered programmed cell death, induced by cellular ferrous ion bursts and subsequent Fenton reactions. The iron source in tumor cells limited due to tightly controlled metabolism. Since hierarchical architecture rarely considered ferroptosis cancer treatment, multilayer Fe 2 O 3 architectures (UF@PPDF NPs) are developed modulating ultra‐small γ‐Fe nanocrystal assemblies, further conjugating targeting folic acid (FA), chemotherapeutic drug doxorubicin...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disease with strong heritability, but recent evidence suggests that epigenetic dysregulation may also contribute to the pathogenesis of ASD. Especially, increased methylation at MECP2 promoter and decreased expression were observed in brains ASD patients. However, causative relationship has not been established. In this study, we achieved locus-specific transcription start site (TSS) Mecp2 Neuro-2a cells mice, using...
Head and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence increasing it now the sixth most common cancer type worldwide. As indicated by existing studies, ferroptosis contributes to HNSCC progression Tanshinone IIA (TanIIA) may exert therapeutic effects via affecting ferroptosis. However, underlying mechanisms have remained be clarified. Therefore, main aim of present study was screen investigate key genes in regulating human hypopharynx line FaDu...
Abstract. Vegetation plays a key role in water conservation the southern Qilian Mountains (northwestern China), located upper reaches of Heihe River. Nitrogen-fixing bacteria are crucial for protection nitrogen supply vegetation region. In present study, nifH gene clone libraries were established to determine differences between nitrogen-fixing bacterial communities Potentilla parvifolia shrubland and Carex alrofusca meadow Mountains. All identified clones belonged Proteobacteria. At genus...
Breast cancer development is associated with macrophage infiltration and differentiation in the tumor microenvironment. Our previous study highlights crucial function of reactive oxygen species (ROS) enhancing during disruption mammary tissue polarity. However, regulation ROS ROS-associated breast has not been fully determined. Previous studies identified retinoid orphan nuclear receptor alpha (RORα) as a potential suppressor human cancer. In present study, we showed that significantly...
A field experiment was conducted to explore the effects of combined application organic and chemical fertilizers (organic-chemical fertilizers) on reclaimed soil fertility rice yield. The involved five treatments: no nitrogen (N) fertilizer (CK1), 100% N (CK2), 40% chicken manure + 60% (T1), vermicompost (T2), rapeseed meal (T3). Organic-chemical maintained or increased Rice yields T2 T3 by 6.7% 8.9%, respectively, as compared with CK2. T1 showed similar value yield contents C (SOC), total...
Head and neck cancer is the main cause of death worldwide, with squamous cell carcinoma (HNSCC) being second most frequent subtype. HNSCC poses significant health threats due to its high incidence poor prognosis, underscoring urgent need for advanced research. Histone modifications play a crucial role in regulation gene expression influencing various biological processes. In context HNSCC, aberrant histone are increasingly recognized as critical contributors development pathologic...
Radiotherapy is one of the main treatments for colorectal cancer (CRC), but due to intrinsic resistance cells or caused by long-term radiotherapy, effectiveness this treatment limited some CRC patients. Consequently, identifying novel sensitization strategies essential. This study identifies Noxa1 as a marker linked radiotherapy in CRC, suggesting its potential prognostic biomarker patients with CRC. The found that was significantly overexpressed radiotherapy-resistant patients, correlating...
// Shuju Zhang 1 , Jiaming Zhiyuan Deng 2 Huadie Liu Wei Mao Fang Jiang Zanxian Xia Jia-Da Li The State Key Laboratory of Medical Genetics and School Life Sciences, Central South University, Changsha, Hunan 410078, China Xiangya Stomatological Hospital, Correspondence to: Li, email: lijiada@sklmg.edu.cn Keywords: MLN4924, osteosarcoma, RORα, Bmal1, neddylation Received: May 03, 2016 Accepted: August 24, Published: September 01, ABSTRACT anticancer small molecule a Nedd8-activating enzyme...
Reasonable cropping systems and fertilizer management are vital for improving the quality of barren soil. The effectiveness different crop rotation methods fertilizers in soil improvement depends on various factors, including type, climate conditions, type. In present study, based three rice-based systems, effects organic combined with slow-release rice yield fertility reclaimed were analyzed. results showed that grain was highest under rice-fallow system (RF) application rapeseed meal...
Lysergic acid diethylamide (LSD), a classical hallucinogen, was used as popular and notorious substance of abuse in various parts the world. Its could result long-lasting abnormalities retina little is known about exact mechanism. This study to investigate effect LSD on macrophage activation state at non-toxic concentration its resultant toxicity photoreceptor cells. Results showed that cytotoxicity caused by 661 W cells after co-culturing with RAW264.7 Treatment LSD-induced M1 phenotype,...
Abstract Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons. Abnormal sheath associated with many neurological diseases. Meningioma-expressed antigen 6 (Mea6)/cutaneous T cell lymphoma-associated 5C (cTAGE5C) plays an important role in vesicle trafficking from the endoplasmic reticulum (ER) to Golgi, and conditional knockout (cKO) of Mea6 brain significantly affects neural development function. However, whether impaired function involves white matter...