A5101690895- RNA modifications and cancer
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Magnetic confinement fusion research
- Fusion materials and technologies
- Superconducting Materials and Applications
- Nuclear reactor physics and engineering
- Genetics and Neurodevelopmental Disorders
- Nuclear Physics and Applications
- Nuclear Materials and Properties
- Advanced Drug Delivery Systems
- Nuclear Engineering Thermal-Hydraulics
- Memory and Neural Mechanisms
- Particle physics theoretical and experimental studies
- Anesthesia and Neurotoxicity Research
- Traditional Chinese Medicine Analysis
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neutrino Physics Research
- Cancer-related molecular mechanisms research
- Protein purification and stability
- Radioactive Decay and Measurement Techniques
- Drug Solubulity and Delivery Systems
University of Chinese Academy of Sciences
2010-2025
Sichuan Agricultural University
2025
Chinese Academy of Sciences
2008-2024
Shenzhen Institutes of Advanced Technology
2021-2024
HKUST Shenzhen Research Institute
2023
China Pharmaceutical University
2023
State Key Laboratory of Natural Medicine
2023
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
ShanghaiTech University
2017-2022
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic messenger RNA (mRNA) and plays critical roles in biology. The function this mediated by m6A-selective ‘reader’ proteins YTH family, which incorporate m6A-modified mRNAs into pathways metabolism. Here, we show that m6A-binding protein YTHDC1 mediates export methylated mRNA from nucleus to cytoplasm HeLa cells. Knockdown results an extended residence time for nuclear m6A-containing mRNA, with accumulation...
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression. However, molecular mechanism by which LHb becomes hyperactive depression remains unknown. Through quantitative proteomic screen, we found that expression β form calcium/calmodulin-dependent protein kinase type II (βCaMΚΙΙ) was significantly up-regulated animal models and down-regulated antidepressants. Increasing β-, but not α-, CaMKII strongly enhanced synaptic efficacy spike output...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disease with strong heritability, but recent evidence suggests that epigenetic dysregulation may also contribute to the pathogenesis of ASD. Especially, increased methylation at MECP2 promoter and decreased expression were observed in brains ASD patients. However, causative relationship has not been established. In this study, we achieved locus-specific transcription start site (TSS) Mecp2 Neuro-2a cells mice, using...
The purpose of this study was to clarify the effect ZC3H13 on growth papillary thyroid carcinoma (PTC).Firstly, we used qRT-PCR and Western blot compare difference in expression between normal epithelial cells PTC cell lines. Then, overexpression/knockout cancer were constructed by lentivirus transfection, effects overexpression proliferation, migration invasion detected CCK8 transwell experiments. Lastly, MeRIP-qPCR, RIP o Actinomycin D verify that regulated downstream target gene IQGAP1...
High-altitude pulmonary edema (HAPE) is a life-threatening disease occurs in hypobaric hypoxia (HH) environment, which could be treated by Dexamethasone, but might cause side-effects. Potentilla anserina L polysaccharide (PAP) holds promising physiological and pharmacological properties beneficial for HAPE treatment. In our study, the anti-hypoxia effect of PAP was firstly investigated through anti-normobaric test anti-acute test. Then we established model measured lung water content,...
Triazoles have demonstrated significant efficacy in the treatment of fungal infections. However, increasing drug resistance is a growing concern that negatively impacts their effectiveness. By designing well-crafted side chain, triazoles can be endowed with advantages, like higher potency and ability to overcome resistance. This highlights diverse interactions between chains CYP51. To explore novel triazole antifungal agents, we synthesized three series fluconazole-core compounds focused on...
The prefrontal cortex (PFC) is essential for higher-level cognitive functions. How epigenetic dynamics participates in PFC development and aging largely unknown. Here, we profiled epigenomic landscapes of rhesus monkey PFCs from prenatal to stages. chromatin states, including higher-order structure, interaction histone modifications are coordinated regulate stage-specific gene transcription, participating distinct processes neurodevelopment. Dramatic changes signals occur around the birth...
Salvianolic acid B (Sal B) is a water-soluble compound found in the traditional Chinese medicine, Radix Salviae miltiorrhizae, and has been widely used to treat variety of diseases Asian cultures. Sal was shown inhibit apoptosis many cell types, but its effect on hepatocyte unknown. In this study, we attempt show that attenuates hepatic injury induced by lipopolysaccharide D-galactosamine mice. also inhibits death receptor HL-7702 line. Apoptosis vitro determined flow cytometry, DNA...
ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the finger family. RNF187 indispensable for proliferation and migration GC‐1 cells derived from mouse spermatogonia GC‐2 spermatocytes. However, it remains unclear whether plays crucial role in self‐renewal human spermatogonial stem (SSCs). In this study, we observed positive correlation between expression SSCs. Through co‐immunoprecipitation mass spectrometry analyses, identified WD...
In this paper, poly(lactic-co-glycolic acid) (PLGA) was used to fabricate spinal cord scaffolds using low temperature deposition manufacturing (LDM) technology. The PLGA were characterized as having good porosity, hydrophilicity and considerable biodegradability. effects of the on cell proliferation cytotoxicity evaluated by culturing Schwann cells (SCs) surfaces scaffolds. results showed that SCs spread proliferated well Histological assessment including Glia fibrillary acidic protein...
Abstract Epigenetic information regulates gene expression and development. However, our understanding of the evolution epigenetic regulation on brain development in primates is limited. Here, we compared chromatin accessibility landscapes transcriptomes during fetal prefrontal cortex (PFC) between rhesus macaques humans. A total 304,761 divergent DNase I-hypersensitive sites (DHSs) are identified humans, although many these share conserved DNA sequences. Interestingly, most cis -elements...
Neutron spectrum is essential to the safe operation of reactors. Traditional online neutron measurement methods still have room improve accuracy for application cases wide energy range. From artificial neural network (ANN) algorithm in unfolding, its difficult be improved lacking enough effective training data. In this paper, an adaptive deviation-resistant unfolding method based on transfer learning was developed. The model ANN trained with thousands spectra generated Monte Carlo transport...