A5022228465- Pluripotent Stem Cells Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Distributed Control Multi-Agent Systems
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Neural Networks Stability and Synchronization
- Cancer-related molecular mechanisms research
- Metal-Organic Frameworks: Synthesis and Applications
- Structural Analysis and Optimization
- Telomeres, Telomerase, and Senescence
- Congenital heart defects research
- Genomics and Chromatin Dynamics
- Nanoparticle-Based Drug Delivery
- Machine Learning and ELM
- Advanced Materials and Mechanics
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
Shanghai East Hospital
2019-2025
Southeast University
2017-2025
Harbin Institute of Technology
2017-2024
Shanghai First Maternity and Infant Hospital
2012-2024
Tongji University
2013-2024
Minzu University of China
2024
Henan Provincial People's Hospital
2019-2024
Zhengzhou University
2024
Zhuhai Fudan Innovation Research Institute
2023
Tsinghua University
2006-2023
Previous studies have revealed the critical roles of N6-methyladenosine (m6A) modification mRNA in embryonic stem cells (ESCs), but biological function m6A large intergenic noncoding RNA (lincRNA) is unknown. Here, we showed that internal linc1281 mediates a competing endogenous (ceRNA) model to regulate mouse ESC (mESC) differentiation. We demonstrated loss compromises mESC differentiation and highly enriched within transcripts. Linc1281 with RRACU sequence motifs, not an m6A-deficient...
Abstract The immoderate use of pesticides in the modern agricultural industry has led to pollution water resources and ultimately threatens human body. Herein, two metal–organic frameworks (MOFs), namely {[Zn(tpt) 2 ·2H O]} n ( Zn1 ) {[Zn (tpt) (bdc)]} Zn2 ), (Htpt = 5‐[4(1 H ‐1,2,4‐triazol‐1‐yl)]phenyl‐2 ‐tetrazole), respectively, are constructed as smart materials for visual on‐site detection their removal from water. exposed nitrogen‐rich sites high chemical stability make a self‐assembly...
Transplanting functional cells to treat myocardial infarction (MI), a major disease threatening human health, has become the focus of global therapy. However, efficacy not been well anticipated, partly due lack microvascular system that supplies nutrients and oxygen. Here, spheroids early vascular (EVCs) derived from embryonic stem (hESCs), rather than single-cell forms, as transplant "seeds" for reconstructing networks, are proposed. Firstly, EVCs containing CD34+ progenitor identified,...
Abstract Background Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs, resulting failure MSC therapy. This study investigated whether the combination melatonin human umbilical cord mesenchymal (hUC-MSCs) was superior hUC-MSCs alone ameliorating high-fat diet streptozocin (STZ)-induced type II diabetes mellitus (T2DM) a mouse model. Methods Mice were divided into four...
Abstract Cell therapy is a promising approach for myocardial infarction (MI) treatment. However, this strategy often restricted by the harsh microenvironment of MI, such as excess ROS, high oxidative stress, inflammation, etc., and thus decreases curative effect. Additionally, distribution, migration, homing transplanted stem cells ambiguous, which also becomes bottleneck clinical translation. To address these challenges, herein, versatile antioxidant nanozyme designed polymerically...
Abstract Background Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate safety and efficacy intravenous infusion human umbilical cord-derived MSCs (HUC-MSCs) patients with aging frailty. Methods randomized, double-blind, placebo-controlled trial, participants diagnosed frailty were randomly assigned receive administrations HUC-MSCs or placebo. All serious adverse events AEs monitored treatment...
Induced pluripotent stem (iPS) cells, especially those reprogrammed from patient somatic have a great potential usage in regenerative medicine. The expression of p53 has been proven as key barrier limiting iPS cell generation, but how is regulated during reprogramming remains unclear. In this study, we found that the ectopic miR-138 significantly improved efficiency generation via Oct4, Sox2, and Klf4, with or without c-Myc (named OSKM OSK, respectively), sacrificing characteristics...
Abstract In pregnancy, trophoblast proliferation, migration and invasion are important for the establishment maintenance of a successful pregnancy. Impaired function has been implicated in recurrent spontaneous abortion (RSA), major complication but underlying mechanisms remain unclear. Indoleamine 2,3-dioxygenase (IDO), an enzyme that catabolizes tryptophan along kynurenine pathway, is highly expressed placenta serum during Here, we identified novel IDO regulating cell proliferation...
Viral infections can alter host transcriptomes by manipulating splicing machinery. Despite intensive transcriptomic studies on SARS-CoV-2, a systematic analysis of alternative (AS) in severe COVID-19 patients remains largely elusive. Here we integrated proteomic and sequencing data to study AS changes patients. We discovered that RNA is among the major down-regulated signatures The transcriptome showed SARS-CoV-2 infection induces widespread dysregulation transcript usage expression,...
Histone deacetylase 10 (HDAC10) is a member of the class II HDACs, and its role in cancer emerging. In this study, we found that HDAC10 highly expressed lung tissues. It resides mainly cytoplasm cells but nucleus adjacent normal cells. Further examinations revealed multiple cell lines, including A549, H358 H460 epithelial 16HBE A leucine-rich motif, R505L506L507C508V509A510L511, was identified as nuclear localization signal (NLS), mutant (Mut-505-511) featuring mutations to at each original...
Over the past decade, traffic heteroscedasticity has been investigated with primary purpose of generating prediction intervals around point forecasts constructed usually by short-term condition level forecasting models. However, despite considerable advancements, complete patterns, in particular seasonal effect, have not adequately handled. Recently, an offline adjustment factor plus GARCH model was proposed Shi <i xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Multifunctional nanomedical platforms have broad prospects in imaging-guided combination therapy cancer precision medicine. In this work, metal-organic framework (MOF)-derived novel porous Fe3O4@C nanocomposites were developed as an intelligent platform for combined with MRI-guided magnetic-triggered hyperthermia and chemotherapy functions. The magnetic behavior, character good surface modification endowed smart nanoplatform favorable biocompatibility, high-efficiency MRI imaging, on-demand...
Induced pluripotent stem cells (iPSCs) have great potential for treating age-related diseases, but the genome integrity of iPSCs is critically important. Here, we demonstrate that non-homologous end joining (NHEJ), rather than homologous recombination (HR), less efficient in from old mice young mice. We further find Sirt6 downregulated directly binds to Ku80 and facilitates Ku80/DNA-PKcs interaction, thus promoting DNA-PKcs phosphorylation at residue S2056, leading NHEJ. Rescue experiments...
This article develops a novel continuous-time algorithm based on the idea of adaptive strategy for solving resource allocation optimization with nonsmooth objective functions and constraints over multiagent network. It is proved that state solution globally bounded finally converges to an optimal convex problem. Compared existing algorithms, strong/strict convexity function relaxed only required. Moreover, by employing exact penalty approach distributed optimization, primal-dual variables...
Fetal growth restriction (FGR) increases the risk for impaired cognitive function later in life. However, precise mechanisms remain elusive. Using dexamethasone-induced FGR and protein restriction-influenced mouse models, we observe learning memory deficits adult offspring. induces decreased hippocampal neurogenesis from early post-natal period to adulthood by reducing proliferation of neural stem cells (NSCs). We further find a persistent decrease Tet1 expression NSCs mice. Mechanistically,...