A5100344186- RNA modifications and cancer
- Peanut Plant Research Studies
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- Acupuncture Treatment Research Studies
- RNA Research and Splicing
- Diet and metabolism studies
- Nerve injury and regeneration
- Agricultural pest management studies
- Complementary and Alternative Medicine Studies
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Lipid metabolism and biosynthesis
- Music Therapy and Health
- Gut microbiota and health
- Healthcare and Venom Research
- Pain Management and Placebo Effect
- Coconut Research and Applications
- Neuroscience and Music Perception
- NF-κB Signaling Pathways
- Alkaline Phosphatase Research Studies
- Opioid Use Disorder Treatment
- Autism Spectrum Disorder Research
- Balance, Gait, and Falls Prevention
Henan Agricultural University
2010-2025
South China Agricultural University
2024-2025
National Institutes of Health
2008-2024
National Center for Complementary and Integrative Health
2017-2024
South China University of Technology
2023-2024
Shihezi University
2019-2024
National Institute on Deafness and Other Communication Disorders
2023
National Institute of Neurological Disorders and Stroke
2023
National Institute on Aging
2009-2023
Institute on Aging
2023
Mutations in MeCP2 , which encodes a protein that has been proposed to function as global transcriptional repressor, are the cause of Rett syndrome (RT T), an X-linked progressive neurological disorder. Although selective inactivation neurons is sufficient confer Rett-like phenotype mice, specific functions postmitotic not known. We find binds selectively BDNF promoter III and repress expression gene. Membrane depolarization triggers calcium-dependent phosphorylation release from III,...
Neuroplasticity can be defined as the ability of nervous system to respond intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in understanding neuroplasticity have date yielded few established interventions. To advance translation research towards clinical applications, National Institutes Health Blueprint for Neuroscience Research sponsored a workshop 2009. Basic researchers disciplines from central injury/stroke, mental/addictive...
Local regulation of mRNA translation plays an important role in axon guidance, synaptic development, and neuronal plasticity. Little is known, however, regarding the mechanisms that control neurons, only a few mRNAs have been identified are locally translated within dendrites. Using Affymetrix gene arrays to identify newly associated with polysomes after exposure BDNF, we subsets for which enhanced neurons at different developmental stages. In mature many these encode proteins known function...
Background.Mobility limitations are common and hazardous in community-dwelling older adults but largely understudied, particularly regarding the role of central nervous system (CNS). This has limited development clearly defined pathophysiology, clinical terminology, effective treatments. Understanding how changes CNS contribute to mobility potential inform future intervention studies.
Improving mammary gland epithelial cells proliferation through nutrition is an important approach for enhancing sow milk production and piglet growth. An intermediate metabolite of valine, 3-hydroxyisobutyrate (3-HIB), regulates cellular lipid metabolism. In the present study, we investigated effects 3-HIB on porcine The addition appropriate concentration significantly increased cell expression proteins associated with proliferation. Compared to control group, 0.4-0.8 mM levels mTOR...
Chondrocyte fate determination and maintenance requires Sox9, an intrinsic transcription factor, but is inhibited by Wnt/beta-catenin signaling activated extrinsic Wnt ligands. Here we explored the underlying molecular mechanism which Sox9 antagonizes in chondrocyte differentiation. We found that employed two distinct mechanisms to inhibit signaling: N terminus necessary sufficient promote beta-catenin degradation, whereas C required transcriptional activity without affecting its stability....
Jatropha curcas is recognized as a new energy crop due to the presence of high amount oil in its seeds that can be converted into biodiesel. The quality and performance biodiesel depends on chemical composition fatty acids present oil. profile has direct impact ignition quality, heat combustion oxidative stability. An ideal should have more monounsaturated less polyunsaturated acids. seed contains 30% 50% (mainly linoleic acid) which negatively impacts stability causes rate nitrogen oxides...
Mobility is crucial for successful aging and impaired in many older adults. We know very little about the subtle, subclinical age-related changes central nervous system (CNS) that mediate mobility impairment. A conference series focused on aging, CNS, was launched. The second addressed major age-associated mechanisms of CNS-mediated Speakers attendees recommended key areas future research, identified barriers to progress, proposed strategies overcome them. Priorities research include (a)...
Music-based interventions (MBIs) show promise for managing symptoms of various brain disorders. To fully realize the potential MBIs and dispel outdated misconception that are rooted in soft science, NIH is promoting rigorously designed, well-powered MBI clinical trials. The pressing need guidelines scientifically rigorous studies with enhanced data collection brought together Renée Fleming Foundation, Foundation NIH, Trans-NIH Music Health Working Group, an interdisciplinary scientific...
To identify molecular mechanisms that control activity-dependent gene expression in the CNS, we have characterized factors mediate transcription of BDNF promoter III. We report identification a Ca(2+)-responsive E-box element, CaRE2, within III binds upstream stimulatory 1 and 2 (USF1/2) show USFs are required for activation CaRE2-dependent from find transcriptional activity is regulated by Ca(2+)-activated signaling pathways neurons bind to promoters number neuronal activity-regulated genes...
Objective. There has been a growing recognition of the need for better pharmacologic management chronic pain among older adults. To address this need, National Institutes Health Pain Consortium sponsored an "Expert Panel Discussion on Pharmacological Management Chronic in Older Adults" conference September 2010 to identify research gaps and strategies them. Specific emphasis was placed ascertaining regarding use opioid nonsteroidal anti-inflammatory medications because continued...
Induced pluripotent stem cells (iPSCs) have great potential for treating age-related diseases, but the genome integrity of iPSCs is critically important. Here, we demonstrate that non-homologous end joining (NHEJ), rather than homologous recombination (HR), less efficient in from old mice young mice. We further find Sirt6 downregulated directly binds to Ku80 and facilitates Ku80/DNA-PKcs interaction, thus promoting DNA-PKcs phosphorylation at residue S2056, leading NHEJ. Rescue experiments...
Abstract Recognition of specific chromatin modifications by distinct structural domains within “reader” proteins plays a critical role in the maintenance genomic stability. However, mechanisms involved this process remain unclear. Here we report that PHD-Bromo tandem domain tripartite motif-containing 66 (TRIM66) recognizes unmodified H3R2-H3K4 and acetylated H3K56. The aberrant deletion Trim66 results severe DNA damage instability embryonic stem cells (ESCs). Moreover, find recognition...
Gut microbiota interfered with using prebiotics may improve bone mass and alleviate the onset of problems. This study aimed to investigate beneficial effect resistant starch from raw potato (RPS) on health in meat ducks. Response dietary graded level RPS supplementation, both tibia strength ash were taken out linear quadratic increase positively correlated increased propionate butyrate levels cecal content. Moreover, further outcomes gut micro-CT analysis showed might be associated higher...
Research suggests that the central nervous system (CNS) and mobility are closely linked. CNS-mediated impairment may represent a potentially new prevalent syndrome within older adult populations. Interventions targeting this group have potential to improve cognition prevent disability. In 2012, Gerontological Society of America (GSA) National Institute on Aging (NIA) sponsored 3-year conference workshop series, "Aging, CNS, Mobility." The goal third final was (i) report state science...