A5052151688- Neurological disorders and treatments
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Neural Networks and Applications
- Cerebral Palsy and Movement Disorders
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Tactile and Sensory Interactions
- Advanced Memory and Neural Computing
- Neurological and metabolic disorders
- Control Systems and Identification
- Assistive Technology in Communication and Mobility
- Action Observation and Synchronization
- Functional Brain Connectivity Studies
- Image and Signal Denoising Methods
- Children's Physical and Motor Development
- COVID-19 Clinical Research Studies
- Glycogen Storage Diseases and Myoclonus
- SARS-CoV-2 and COVID-19 Research
- Autism Spectrum Disorder Research
Children's Hospital of Orange County
2021-2024
University of California, Irvine
2020-2024
Children's Hospital
2024
Samueli Institute
2023
University of Southern California
2013-2022
Florida Department of Health in Orange County
2022
Children's Hospital of Los Angeles
2010-2021
Indiana University School of Medicine
2020
Biokine (Israel)
2018
American Physical Therapy Association
2015-2017
Neuroplasticity can be defined as the ability of nervous system to respond intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in understanding neuroplasticity have date yielded few established interventions. To advance translation research towards clinical applications, National Institutes Health Blueprint for Neuroscience Research sponsored a workshop 2009. Basic researchers disciplines from central injury/stroke, mental/addictive...
1 Intracortical inhibition in the human motor cortex has been previously demonstrated using paired-pulse transcranial magnetic stimulation (TMS) protocols at short intervals (1-6 ms; interval intracortical inhibition, SICI) with a subthreshold conditioning pulse preceding suprathreshold test pulse, and long (50-200 LICI) pulses. 2 We investigated whether different circuits mediate these inhibitory phenomena how they interact. In nine healthy volunteers, we applied TMS to recorded evoked...
1. Electrophysiological recording data from multiple cells in motor cortex and elsewhere often are interpreted using the population vector method pioneered by Georgopoulos coworkers. This paper proposes an alternative for interpreting coding across populations of that may succeed under circumstances which fails. 2. Population codes analyzed probability theory to find complete conditional density a movement parameter given firing pattern set cells. 3. The when single cell fires is...
dopamine transporter deficiency syndrome is the first identified parkinsonian disorder caused by genetic alterations of transporter. We describe a cohort children with mutations in gene encoding (SLC6A3) aim to improve clinical and molecular characterisation, reduce diagnostic delay misdiagnosis, provide insights into pathophysiological mechanisms.11 biochemical profile suggestive were enrolled from seven paediatric neurology centres UK, Germany, USA February, 2009, studied until June, 2010....
We tested the feasibility of a computer based at-home testing device (AHTD) in early-stage, unmedicated Parkinson's disease (PD) patients over 6 months. measured compliance, technical reliability, and patient satisfaction to weekly assessments tremor, small large muscle bradykinesia, speech, reaction/movement times, complex motor control. relative UPDRS score. The AHTD is 6.5'' x 10'' computerized assessment battery. Data are stored on USB memory stick sent by internet central data...
Object Deep brain stimulation (DBS) is an established technique for the treatment of several movement disorders in adults. However, technical approach, complications, and results DBS children have not been well documented. Methods A database implantations performed at a single institution, prospectively 1998, was reviewed patients who received prior to age 18. Diagnoses, surgical technique, complications were noted. Outcomes assessed using standard rating scales neurological function....
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a clinically heterogeneous disorder with number of different etiologies and disease mechanisms. Inflammatory postinfectious autoimmune presentations PANS occur frequently, some clinical series documenting immune abnormalities in 75%-80% patients. Thus, comprehensive treatment protocols must include immunological interventions, but their use should be reserved only for cases which the symptoms represent underlying neuroinflammation or...
Data on coronavirus disease 2019 (COVID-19) infections in neonates are limited. We aimed to identify and describe the incidence, presentation, clinical outcomes of neonatal COVID-19.Over 1 million encounters at 109 United States health systems, from March 2020 February 2021, were extracted Cerner Real World Database. COVID-19 diagnosis was assessed using severe acute respiratory syndrome 2 (SARS-CoV-2) laboratory tests codes. Incidence per 100 000 estimated.COVID-19 diagnosed 918 (0.1%)...
To explore the concept that dystonia may result from dysfunction of sensory system, 14 patients with focal hand were tested during two somatosensory discrimination tasks. Compared controls, had a higher threshold in task involving electric stimuli closely related temporally, an abnormality correlated degree severity dystonia. There was no significant difference single-touch, gross localization task. The possible relevance these findings to pathogenesis is discussed. Ann Neurol 2000;47:377–380
Nonlinear function approximation is often solved by finding a set of coefficients for finite number fixed nonlinear basis functions. However, if the input data are drawn from high-dimensional space, required functions grows exponentially with dimension, leading many to suggest use adaptive whose parameters can be determined iterative methods. The author proposes technique based on idea that most data, only few dimensions may necessary compute desired output function. Additional incorporated...
Surface electromyography is used in research, to estimate the activity of muscle, prosthetic design, provide a control signal, and biofeedback, subjects with visual or auditory indication muscle contraction. Unfortunately, successful applications are limited by variability signal consequent poor quality estimates. I propose use nonlinear recursive filter based on Bayesian estimation. The desired filtered modeled as combined diffusion jump process measured electromyographic (EMG) random...
The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current (1) use and utility complex neurophysiological signals for development adaptive neurostimulation to improve clinical outcomes; (2) Advancements in recent neuromodulation techniques treat neuropsychiatric disorders; (3) New developments optogenetics DBS; (4) augmented virtual reality neuromodulation; (5) commercially available technologies (6) ethical issues arising from...
Trajectory extension learning is an incremental method for training artificial neural network to approximate the inverse dynamics of a robot manipulator. Training data near desired trajectory obtained by slowly varying parameter from region easy solvability toward behavior. The can be average speed, path shape, feedback gain, or any other controllable variable. As proceeds, solution local each value used guide next parameter. Convergence conditions are given two variations on algorithm....
A new method for analyzing kinematic patterns during smooth movements is proposed. Subjects are asked to move the end of a two-joint manipulandum copy initial target path. On subsequent trials path subject's actual movement from preceding trial. Using Principal Components Analysis, it shown that trajectories have very low dimension and they converge toward linear superposition first few principal components. We show similar results handwriting on an electronic pen tablet. hypothesize...
Recent evidence of population coding in motor cortex has led some researchers to claim that certain variables such as hand direction or force may be coded within a Cartesian coordinate system with respect extra personal space. These claims are based on the ability predict rectangular coordinates movement using “population vector” computed from multiple cells' firing rates. I show here vector can always found given very general set assumptions. Therefore existence constitutes only weak...
Background Dystonia is a movement disorder in which involuntary sustained or intermittent muscle contractions cause twisting and repetitive movements, abnormal postures, both. It can be classified as primary secondary. There no cure for dystonia the goal of treatment to provide better quality life patient. Surgical intervention considered patients whom an adequate trial medical has failed. Deep brain stimulation (DBS), specifically globus pallidus interna (GPi), been shown extremely...
In this study, we test the feasibility of synergy- based approach for application in realistic and clinically oriented framework multi-degree freedom (DOF) robotic control. We developed tested online ten able-bodied subjects a semi-supervised method to achieve simultaneous, continuous control two DOFs arm, using muscle synergies extracted from upper limb muscles while performing flexion-extension movements elbow shoulder joints horizontal plane. To validate efficacy synergy-based extracting...