A5100692458- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- CRISPR and Genetic Engineering
- Advanced Fluorescence Microscopy Techniques
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Near-Field Optical Microscopy
- Gastric Cancer Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Photoacoustic and Ultrasonic Imaging
- Integrated Circuits and Semiconductor Failure Analysis
- MicroRNA in disease regulation
- RNA Research and Splicing
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Anorectal Disease Treatments and Outcomes
- Spectroscopy Techniques in Biomedical and Chemical Research
- Genomics and Phylogenetic Studies
Hebei Medical University
2016-2025
Second Hospital of Hebei Medical University
2022-2025
Yunnan Agricultural University
2025
Fourth Hospital of Hebei Medical University
2012-2024
Third Hospital of Hebei Medical University
2020-2023
Wuhan Academy of Agricultural Sciences
2014-2023
First People's Hospital of Chongqing
2023
National Animal Husbandry Service
2020
Shanxi Datong University
2016-2019
Shanghai First Maternity and Infant Hospital
2011-2018
Previous studies have revealed the critical roles of N6-methyladenosine (m6A) modification mRNA in embryonic stem cells (ESCs), but biological function m6A large intergenic noncoding RNA (lincRNA) is unknown. Here, we showed that internal linc1281 mediates a competing endogenous (ceRNA) model to regulate mouse ESC (mESC) differentiation. We demonstrated loss compromises mESC differentiation and highly enriched within transcripts. Linc1281 with RRACU sequence motifs, not an m6A-deficient...
Fibroblasts can be reprogrammed to induced pluripotent stem cells (iPSCs) by application of transcription factors octamer-binding protein 4 (Oct4), SRY-box containing gene 2 (Sox2), Kruppel-like factor (Klf4), and c-Myelocytomatosis oncogene (c-Myc) (OSKM), but the underlying mechanisms remain unclear. Here, we report that exogenous Oct4 Sox2 bind at promoter regions mir-141/200c mir-200a/b/429 cluster, respectively, induce activation miR-200 family during OSKM-induced reprogramming....
Induced pluripotent stem (iPS) cells, especially those reprogrammed from patient somatic have a great potential usage in regenerative medicine. The expression of p53 has been proven as key barrier limiting iPS cell generation, but how is regulated during reprogramming remains unclear. In this study, we found that the ectopic miR-138 significantly improved efficiency generation via Oct4, Sox2, and Klf4, with or without c-Myc (named OSKM OSK, respectively), sacrificing characteristics...
Sin3a is a core component of histone-deacetylation-activity-associated transcriptional repressor complex, playing important roles in early embryo development. Here, we reported that down-regulation led to the loss embryonic stem cell (ESC) self-renewal and skewed differentiation into mesendoderm lineage. We found functioned as coactivator critical Nodal antagonist Lefty1 through interacting with Tet1 de-methylate promoter. Further studies showed two amino acid residues (Phe147, Phe182) PAH1...
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) mitochondrial DNA (mtDNA) has been identified for their association with cancer risk a number cancers. We investigated colon profile D-Loop SNPs case–control study. frequent alleles nucleotides 73G/A, 146T/C, 195T/C, 324C/G, 16261C/T, and 16304T/C as well minor allele 309C/C insert were significantly associated an increased cancer. In conclusion, mtDNA found to be valuable markers evaluation.
Histone deacetylase 10 (HDAC10) is a member of the class II HDACs, and its role in cancer emerging. In this study, we found that HDAC10 highly expressed lung tissues. It resides mainly cytoplasm cells but nucleus adjacent normal cells. Further examinations revealed multiple cell lines, including A549, H358 H460 epithelial 16HBE A leucine-rich motif, R505L506L507C508V509A510L511, was identified as nuclear localization signal (NLS), mutant (Mut-505-511) featuring mutations to at each original...
Venous thromboembolism (VTE) is a common and serious complication after colorectal cancer (CRC) surgery. Few large-sample studies have reported VTE incidence management status CRC surgery in China. This study aimed to investigate the prevention of Chinese patients surgery, identify risk factors for developing VTE, construct new scoring system clinical decision-making care planning.Participants were recruited from 46 centers 17 provinces Patients followed up 1 month postoperatively. The...
Euphorbia tirucalli is a long‑established treatment for wide variety of cancers. However, the mechanism its anticancer effect yet to be elucidated. In present study, we examined euphol, tetracyclic triterpene alcohol isolated from sap tirucalli, in T47D human breast cancer cells. Following cells with different doses euphol 24, 48 and 72 h, cell proliferation, cycle, mRNA protein levels cycle regulatory molecules were analyzed, respectively. Treatment resulted decreased viability, which was...
Targeted molecular therapy is the most effective treatment for cancer. An therapeutic target colorectal cancer (CRC) urgently needed. However, mechanisms of CRC remain poorly understood, which has hampered research and development CRC-targeted therapy. TRIM29 a ubiquitin E3 ligase that been reported as an oncogene in several human tumors. In this study, we show increased levels were detected compared with normal tissues associated poor clinical outcome, advanced stage lymph node metastasis,...
Angiogenesis is crucially involved in many physiological and pathological processes including tumor growth, but the molecular mechanisms regulating angiogenesis are incompletely understood. In this study, we investigated functions mechanism of histone deacetylase 10 (HDAC10), a member HDAC II family, regulation angiogenesis. HDAC10 overexpression human umbilical vein endothelial cells (HUVECs) promoted tube formation, whereas depletion from HUVECs inhibited formation vitro vivo....
Paclitaxel is widely used as a first-line chemotherapy agent to treat malignant tumors. However, paclitaxel causes peripheral nerve fiber damage and neuropathic pain in some patients. In addition, patients received are often accompanied by negative emotions such anxiety. The amygdala critically involved regulating signals, well purpose of this study clarify the role Ca2+/calmodulin-dependent protein kinase II (CaMKII)-positive glutamatergic neurons paclitaxel-induced affective symptoms....
Paclitaxel (PTX) is a commonly used antitumor drug. Approximately 80% of all patients receiving PTX chemotherapy develop chemotherapy-induced peripheral neuropathy (CIPN), limiting the use PTX. Moreover, CIPN responds poorly to conventional analgesics. Experimental evidence suggests that neuroinflammatory response plays an essential role in paclitaxel-induced (PIPN). Previous studies have confirmed dorsal root ganglion (DRG) neuron necroptosis and accompanying inflammation are linked with...
Sirt2, a member of the NAD+-dependent protein deacetylase family, is increasingly recognized as critical regulator cell cycle, cellular necrosis and cytoskeleton organization. However, its role in embryonic stem cells (ESCs) remains unclear. Here we demonstrate that Sirt2 up-regulated during RA (retinoic acid)-induced embryoid body (EB) differentiation mouse ESCs. Using lentivirus-mediated shRNA methods, found knockdown compromises ESCs into ectoderm while promoting mesoderm endoderm...
Embryonic stem cells (ESCs) enable rapid proliferation that also causes DNA damage. To maintain genomic stabilization during proliferation, ESCs must have an efficient system to repress genotoxic stress. Here, we show withdrawal of leukemia inhibitory factor (LIF), which maintains the self-renewal capability mouse (mESCs), significantly inhibits cell and damage mESCs upregulates expression miR-590. miR-590 promotes single-strand break (SSB) double-strand (DSB) repair, thus slowing without...
// Guobiao Fan 1, 2 , Dan Ye 1 Songcheng Zhu Jiajie Xi Xudong Guo Jing Qiao Yukang Wu Wenwen Jia Guiying Wang Guohuang and Jiuhong Kang Clinical Translational Research Center of Shanghai First Maternity Infant Health Hospital, Key Laboratory Signalling Disease Research, Collaborative Innovation for Brain Science, School Life Science Technology, Tongji University, 200092, China Skin Cosmetic Department, 200443, Correspondence to: Kang, email: jhkang@tongji.edu.cn Wang, wgy@tongji.edu.cn Fan,...
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) is a gene that encodes an anion-transporting polypeptide (OATP) 1B3, membrane-bound multi-specific in hepatocytes. SLCO1B3 was first reported Later, it found its expression higher colorectal cancer (CRC) than the adjacent normal tissue. However, role of CRC not well elucidated. In this study, correlation between and overall survival (OS) patients evaluated using data from GEO database. This study relationship...
Abstract Background Few studies have investigated the depth of intraoperative analgesia with non-opioid anesthesia. This study evaluated whether opioid-free anesthesia can provide an effective analgesia-antinociception balance monitored by / pain threshold index in laparoscopic radical colectomy. Methods We enrolled 102 patients undergoing colectomy general Participants were randomly allocated into two groups to receive (group OFA) dexmedetomidine (loading dose 0.6 μg·kg −1 for 10 min and...