A5101741988- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Frailty in Older Adults
- Pancreatic and Hepatic Oncology Research
- Proteoglycans and glycosaminoglycans research
- Hair Growth and Disorders
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Inflammasome and immune disorders
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Wound Healing and Treatments
- Galectins and Cancer Biology
- TGF-β signaling in diseases
- Gene expression and cancer classification
- Dietary Effects on Health
- RNA modifications and cancer
- Immune cells in cancer
- Electrospun Nanofibers in Biomedical Applications
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- COVID-19 epidemiological studies
Shanghai East Hospital
2014-2025
Tongji University
2013-2025
Nanjing Medical University
2014-2024
Obstetrics and Gynecology Hospital of Fudan University
2024
Nanjing Maternity and Child Health Care Hospital
2022
First Hospital of China Medical University
2022
China Medical University
2022
China Pharmaceutical University
2022
Changzhou No.2 People's Hospital
2018-2020
Mudanjiang Medical University
2018-2019
The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety human diseases. A few compounds have developed to inhibit activation, but directly and specifically targeting are still not available, so it is unclear whether itself can be targeted prevent or treat Here we show that compound CY-09 blocks activation. binds ATP-binding motif NACHT domain inhibits ATPase activity, resulting suppression assembly Importantly, treatment with shows remarkable therapeutic effects on...
Gastric cancer (GC) is the third leading cause of cancer-related mortality globally. Long noncoding RNAs (lncRNAs) are dysregulated in obvious malignancies including GC and exploring regulatory mechanisms underlying their expression an attractive research area. However, these molecular require further clarification, especially upstream mechanisms. LncRNA MNX1-AS1 tissue samples was investigated via microarray analysis determined a cohort tissues quantitative reverse transcription polymerase...
Circular RNAs (circRNAs) are key regulators in the development and progression of human cancers, however its role non-small cell lung cancer (NSCLC) tumorigenesis is not well understood. The aim this study to identify expression level circPVT1 NSCLC further investigated functional relevance with both vitro vivo.Quantative real-time PCR was used for measurement specimens lines. Fluorescence situ hybridization analysis (FISH) assay identification sublocation cells. Bioinformatics analysis,...
We aimed to explore the burden of thyroid cancer worldwide from 1990 2019 and project its future trends 2020 2030.
Abstract Background Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate safety and efficacy intravenous infusion human umbilical cord-derived MSCs (HUC-MSCs) patients with aging frailty. Methods randomized, double-blind, placebo-controlled trial, participants diagnosed frailty were randomly assigned receive administrations HUC-MSCs or placebo. All serious adverse events AEs monitored treatment...
3D-printed hydrogel scaffolds are widely utilized in auricular cartilage tissue engineering. However, issues such as graft-related inflammation, poor mechanical properties, and the lack of external modulation vivo have raised significant concerns. To address these challenges, a "fried egg" structure is designed, consisting chitosan-coated ferroferric oxide magnetic nanoparticles (Fe3O4@CS MNPs), which uniformly incorporated into hydrogel. Through 4D printing technology, magnetoresponsive...
Androgenic alopecia (AGA) is a highly prevalent form of non-scarring but lacks effective treatments. Stem cell exosomes have similar repair effects to stem cells, suffer from the drawbacks high cost and low yield yet. Cell-derived nanovesicles acquired through mechanical extrusion exhibit favorable biomimetic properties exosomes, enabling them efficiently encapsulate substantial quantities therapeutic proteins. In this study, we observed that JAM-A, an adhesion protein, resulted in...
Loading human umbilical mesenchymal stem cell (hUMSC) derived exosomes onto hydrogel scaffolds is a strategy for rapid wound healing. The clinical application of hindered by low production, and exosome mimetics could be substituted exosomes. Here, the therapeutic effects exosome-loaded hydrogels mimetic-loaded on wounds are evaluated. Our results revealed that promote healing more efficiently than hydrogels. Exosome can proliferation migration dermal fibroblasts (hDF-a) cells in vitro. To...
Lung cancer is the most common cause of cancer-related mortality worldwide, and nonsmall cell lung (NSCLC) accounts for 80% all pulmonary carcinomas. Recently, long noncoding RNAs (lncRNAs) have been paid attention exploring treatment various diseases. Upregulation DiGeorge syndrome critical region gene 5 (DGCR5) predicts better squamous carcinoma prognosis; therefore, we explore role DGCR5 in our present study. Consecutive patients with LC were treated hospital between January 2015 2016....
Hepatocellular carcinoma (HCC) is a highly aggressive worldwide. Circular RNAs (circRNAs) have been proved to be involved in the pathogenesis of several carcinomas. circ_0000267 was reported elevated HCC tissue samples by circRNA microarray. In this study, quantitative reverse-transcription polymerase chain reaction induced further detect expression tissues and cells. The clinical significance also explored Fisher's exact test, Kaplan-Meier curves Cox regression analysis. Cell counting...
Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome cancer may provide new approaches targets anticancer therapy. The aim this study is to examine relationship between expression RhoT1, Smad4 p16 survival in patients analysis showed that high cytoplasmic levels tissues had significantly negative correlation lymph node (LNM) (P = 0.017, P 0.032, 0.042, respectively). However, no...
Background The tumor microenvironment (TME) contains a variety of immune cells, which play critical roles during the multistep development tumors. Histone deacetylase 9 (HDAC9) has been reported to have either proinflammatory or anti-inflammatory effects, depending on environment. In this study, we investigated whether HDAC9 in stroma regulated inflammation and antitumor immunity. Methods Hdac9 knockout mice were generated analyze HDAC9-associated progression. Immune cells cytokines TME...
The COVID-19 pandemic is currently spreading widely around the world, causing huge threats to public safety and global society. This study analyzes spatiotemporal pattern of in China, reveals China’s epicenters through spatial clustering, delineates substantial effect distance Wuhan on spread. results show that daily new cases mostly occurred before March 6, then moved Grand Bay Area (Shenzhen, Hong Kong Macau). total China were mainly distributed east Huhuanyong Line, where accounted for...
Background: Abnormal expression of circular RNA (circRNA) has been shown to play an important role in the progression cancer. However, circRNAs on nonsmall cell lung cancer (NSCLC) remains largely unknown. This study aims reveal effects and potential mechanisms circRNA NSCLC proliferation apoptosis. Materials Methods: Real-time quantitative polymerase chain reaction was used detect circ_0014130 tissues cells. After silencing cells H1299 A549, MTT assay or flow cytometry performed analyze...
Novel functions and involvement of circFARSA have not been reported in pancreatic cancer; addition, its inhibitor screening has yet conducted. The purpose this study was to (1) verify as a novel anti-cancer target for cancer (2) prepare anti-pancreatic agent targeting circFARSA. In study, we designed synthesized small interfering RNA (siRNA, named siRNA-circFARSA), which specifically inhibits expression. Using liposomes porous silicon nanoparticles (pSiNPs) siRNA delivery system, prepared...