Background: The reproducibility and non-redundancy of radiomic features are challenges in accelerating the clinical translation radiomics. In this study, we focused on robustness extracted from computed tomography (CT) scans hepatocellular carcinoma (HCC) patients with respect to different tumor segmentation methods. Methods: Arterial enhanced CT images were retrospectively randomly obtained 106 patients. As a training data set, 26 HCC used calculate features' redundancy. Another set (55 25...

Abstract Purpose To construct machine learning models for predicting progression free survival (PFS) and overall (OS) with esophageal squamous cell carcinoma (ESCC) patients. Methods 204 ESCC patients were randomly divided into training cohort (n = 143) test 61) according to the ratio of 7:3. Two radiomics constructed by features, which selected LASSO Cox model predict PFS OS, respectively. Clinical features univariate multivariate proportional hazards ( p < 0.05). Combined clinical was...

Abstract Background The existing staging system cannot meet the needs of accurate survival prediction. Accurate prediction for locally advanced cervical cancer (LACC) patients who have undergone concurrent radiochemotherapy (CCRT) can improve their treatment management. Thus, this present study aimed to develop and validate radiomics models based on pretreatment 18 Fluorine-fluorodeoxyglucose ( F-FDG) positron emission tomography (PET)-computed (CT) images accurately predict prognosis in...

Lung cancer is the most common cause of cancer-related mortality worldwide, and nonsmall cell lung (NSCLC) accounts for 80% all pulmonary carcinomas. Recently, long noncoding RNAs (lncRNAs) have been paid attention exploring treatment various diseases. Upregulation DiGeorge syndrome critical region gene 5 (DGCR5) predicts better squamous carcinoma prognosis; therefore, we explore role DGCR5 in our present study. Consecutive patients with LC were treated hospital between January 2015 2016....

Nanosilver paste has become a promising lead-free die-attach material for power electronic packaging. This development solves the challenges faced by device manufacturers to replace lead-based or solders high-temperature applications. paper proposes reliability of 1200-V/150-A multichip insulated-gate bipolar transistor (IGBT) module using pressureless sintering nanosilver as die attachment. The degradation in harsh environment was compared between proposed IGBT sintered and commercial one...

Abstract Objective To investigate the value of differential diagnosis hepatocellular carcinoma (HCC) and non-hepatocellular (non-HCC) based on CT MR multiphase radiomics combined with different machine learning models compare diagnostic efficacy between models. Background Primary liver cancer is one most common clinical malignancies, subtype primary cancer, accounting for approximately 90% cases. A clear HCC important individualized treatment patients HCC. However, more sophisticated...

To increase the sales of agricultural products in e-commerce, understanding customer preferences is essential. In web applications, data mining techniques can help farmers analyze behavior patterns and identify preferences, thus optimizing product design or offering more precise personalized services, which, turn, enhance farmers’ decision-making production. This study proposes a application user prediction method based on deep forest, which addresses issue traditional learning methods...

This study is aimed to develop and validate a machine learning model, which combined radiomics clinical characteristics predicting the definitive chemoradiotherapy (dCRT) treatment response in esophageal squamous cell carcinoma (ESCC) patients. 204 advanced ESCC patients were included who underwent dCRT at our hospital. Patients randomly divided into training cohort validation with ratio of 7:3. The features selected by LASSO algorithm. multivariate logistics analysis (p < 0.05)....

Xerostomia induced by radiotherapy is a common toxicity for head and neck carcinoma patients. In this study, the deformable image registration of planning computed tomography (CT) weekly cone-beam CT (CBCT) was used to override Hounsfield unit value CBCT, modified CBCT introduced estimate radiation dose delivered during course treatment. Herein, beams from each patient's treatment plan were applied construct dose. Then, doses summed together obtain accumulated A total 42 parotid glands (PGs)...

Evidence has also shown that micro ribonucleic acid (miRNA) plays an important role in many cellular processes. However, it is unclear how ionizing radiation causes the miRNA and circular (circRNA) expression levels to change this relates esophageal injury. We analyzed RNA Sequencing (RNA-seq) data from normal tissue irradiated tissues used computational approaches identify characterize differentially expressed miRNAs circRNAs. detected 27 197 circRNAs had significantly different after...

Wide-bandgap power devices are usually operated at a higher temperature or larger electrical bias and the harsh conditions often lead to early failure of widely used Ag-based die-attach materials due electrochemical migration (ECM). Common methods mitigate ECM tend be quite costly can only enhance performance slightly under high-temperature conditions. In this letter, novel nano-Ag-based designed prepared by doping with 0.1 wt% Si nanoparticles. The affinity oxygen reduces oxidation silver...

This study is to distinguish peripheral lung cancer and pulmonary inflammatory pseudotumor using CT-radiomics features extracted from PET/CT images.In this study, the standard 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18 F-FDG PET/CT) images of 21 patients with (PIPT) were retrospectively collected. The dataset was used extract regions interest (ROI), intra-class correlation coefficient (ICC) screen robust feature all radiomic features. Using, then,...

Abstract Objective To show the feasibility of using a knowledge‐based RapidPlan model to generate new cervical intensity modulated radiation therapy (IMRT) plans. Methods A database 20 IMRT treatment plans was assembled create model. Another 19 clinical cases were selected test comparison analysis difference in dose–volume histograms between semiautomated and original carried out. Results On average, RapidPlans can achieve planning target volume coverage that is highly comparable with plan,...

This paper proposed a new approach to attach power devices on nonmetallized direct bonding copper (DBC) substrates by pressureless sintering of nanosilver paste in poor-oxygen atmosphere and formic acid reduction atmosphere. The average shear strength die-attach joints could reach 25 MPa, the oxidation issue DBC was avoided. Based paste, insulated-gate bipolar transistor (IGBT) modules were prototyped verify feasibility this for mass production modules. electrical thermal characteristics...

High temperature application and long-term reliability are the future development trends of IGBT (insulated gate bipolar transistor) module. This article proposes a 1200-V/50-A module using current-assisted sintered nanosilver as die attachment high-temperature solder substrate attachment. We measured compared electrical thermal characteristics, proposed modules with those commercial same level. The show consistency in performance, which also proved feasibility sintering. impedance decreased...

Abstract The increasing cancer burden calls for reliably assessed changes in the hospitalizations tumors over time and space China. This study evaluated trends hospitalization rate, in-hospital mortality, length of stay (LOS), medical costs malignant benign neoplasms. Data were derived from China Health Statistical Yearbooks 2004 to 2020. Temporal rates mortality through Cochran-Armitage Test. We used linear model with continuous variables test trend. neoplasm rate increased 1.1‰ 5.8‰ 1.0‰...

To validate a gradient-based segmentation method for gross tumor volume(GTV) delineation on 8F-fluorothymidine (FLT)positron emission tomography (PET)/ computer (CT) in esophageal squamous cell cancer through pathologic specimen, comparison with standardized uptake values (SUV) threshold-based methods and CT. The corresponding impact of this GTV treatment planning was evaluated. Ten patients were enrolled. Before radical surgery, all underwent FLT-PET/CT. GTVs delineated by using four...

The correlations between early responses and the variations in physical density primary tumor volume (TV) according to cone-beam computed tomography (CBCT) during chemoradiotherapy for non-small cell lung cancer (NSCLC) patients were investigated. 54 with inoperable locally advanced NSCLC included this study. CT numbers (CTN) TV measured on each of seven observation points. changes mean CTN values variation ratios treatment course analysed correlated clinical outcomes, as evaluated by RECIST...

On-board kilovoltage (KV) cone-beam computed tomography (CBCT) images are used predominantly for the setup of patients' positioning. The image data can also potentially be dose calculation with precise calibration Hounsfield units (HU) to electron density (HU-density). CBCT was analyzed in this study. A clinical treatment planning system employed CT and KV calculations subsequent comparisons. Two HU-density tables were generated using Computerized Imaging Reference Systems (CIRS) phantom....

This paper presents the design, development, and optimization of large-area die attachment by pressureless sintering nanosilver paste. With proposed attachment, a high power 1200 V/150 A insulated-gate-bipolar-transistor (IGBT) module is fabricated using IGBT (12.56 × 12.56 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) diode (6.3 6.3 chips. The average die-shear strength higher than 30 MPa can be obtained with low void ratio 1.8%....

The aim of this study is to evaluate anatomic lung tumor changes and dosimetric consequences utilizing the deformable daily kilovolt (KV) cone-beam computer tomography (CBCT) image registration. Five patients diagnosed with NSCLC were treated three-dimensional conformal radiotherapy (3D CRT) 10 KV CBCT sets acquired for each patient. Each plan CT imported into registration (DIR) system. was deformed by DIR system a new contour on obtained using auto-contouring function DIR. These contours...

The aim of this paper is to compare the dosimetric difference between intensity-modulated arc therapy (IMAT) and conventional radiation (IMRT) for radiotherapy nasopharyngeal carcinoma (NPC) using simultaneously integrated boost (SIB) protocol. Ten patients with underwent SIB protocol were retrospectively studied. plan target volume (PTV) NPC contained nasopharynx gross positive neck lymph nodes, PTV1 high-risk sites microscopic extension whole PTV2 low-risk sites. prescription dose PTV was...