A5101944791- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- MRI in cancer diagnosis
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Advanced MRI Techniques and Applications
Xinjiang Medical University
2016-2024
Tumor Hospital of Xinjiang Medical University
2016-2024
Xinjiang Uygur Autonomous Region Uygur Medicine Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2021
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2021
Innate lymphoid cells (ILC) are part of a heterogeneous family haematopoietic effector which lack re-arranged antigen-specific receptors. They promote host defense and contribute to tissue metabolic homeostasis, wound healing immune surveillance. Their role in human cancer immunity is less defined, therefore we aimed identify the frequency phenotype distinct ILC groups various types cancer.Tissue samples peripheral blood were collected from patients undergoing surgical resection...
Noninvasive differentiation between the squamous cell carcinoma (SCC) and adenocarcinoma (ADC) subtypes of non-small lung cancer (NSCLC) could benefit patients who are unsuitable for invasive diagnostic procedures. Therefore, this study evaluates predictive performance a PET/CT-based radiomics model. It aims to distinguish histological carcinoma, employing four different machine learning techniques. A total 255 Non-Small Cell Lung Cancer were retrospectively analyzed randomly divided into...
Abstract Background The existing staging system cannot meet the needs of accurate survival prediction. Accurate prediction for locally advanced cervical cancer (LACC) patients who have undergone concurrent radiochemotherapy (CCRT) can improve their treatment management. Thus, this present study aimed to develop and validate radiomics models based on pretreatment 18 Fluorine-fluorodeoxyglucose ( F-FDG) positron emission tomography (PET)-computed (CT) images accurately predict prognosis in...
Purpose This study was designed to determine the diagnostic performance of fluorine-18-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed (CT) radiomics-based machine learning (ML) in classification cervical adenocarcinoma (AC) and squamous cell carcinoma (SCC). Methods Pretreatment F-FDG PET/CT data were retrospectively collected from patients who diagnosed with locally advanced cancer at two centers. Radiomics features extracted selected by Pearson correlation...
Despite the expansion of PD-1 checkpoint blockade to multiple types cancer, whether programmed cell death 1 (PD-1) expression status on CD8+ tumour infiltrating lymphocytes (TILs) could be a prognostic factor in cervical cancer is still unclear. In this study, we performed ex vivo phenotypic analysis TILs by flow cytometry from 47 treatment-naïve patients. With median follow-up 26.1 months (95% confidence interval [CI], 24-28.2 months), then linked quantitative cellular results...
Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in planning treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as prospective superior procedure compared with intensified computed tomography (CT) and positron emission (PET) cancer. However, implication DW-MRI lung cancer, leading cause cancer-associated mortality worldwide, not been extensively evaluated. In present study, gross volumes masses...
Cervical cancer is attributable to human papilloma virus (HPV) infection in the majority cases. E1, an HPV derived-protein, plays important role initiation and development of cervical cancer. Our study aims investigate E1-specific T cell response patients with squamous carcinoma (CSCC). A total 66 CSCC FIGO stage IIB-IIIB 60 healthy controls were enrolled. Enzyme-Linked ImmunoSpot (ELISPOT) assays was used measure peripheral blood these before treatment. The treated chemotherapy and/or...
Abstract Background T cell epitopes are polypeptide fragments presented to receptors by MHC molecules encoded human leukocyte antigen (HLA) genes after antigen-presenting processing, which is the basis for study of immune mechanism and multi-epitope vaccine. This investigated response HPV16 E6 E7 in patients with cervical squamous carcinoma (CSCC). Also, HLA-A allele distribution was compared among evaluated as a factor predict prognosis these patients. Materials methods recruited total 76...
Background: This study was conducted to investigate the distribution of human leukocyte antigen (HLA)-A alleles in advanced squamous cell cervical cancer patients (IIb–IVb SCC) and their relationship papillomavirus (HPV) status clinical outcome.Methods: From May 2012 March 2016, 231 SCC (169 Uyghur 62 Han individuals) 197 control subjects (101 96 from Xinjiang province were genotyped for HLA-A by polymerase chain reaction sequence-based typing (PCR-SBT). The frequencies compared among...
Background: This study was conducted to investigate the distribution of human leukocyte antigen (HLA)-A alleles in advanced squamous cell cervical cancer patients (IIb–IVb SCC) and their relationship papillomavirus (HPV) status clinical outcome. Methods: From May 2012 March 2016, 231 SCC (169 Uyghur 62 Han individuals) 197 control subjects (101 96 from Xinjiang province were genotyped for HLA-A by polymerase chain reaction sequence-based typing (PCR-SBT). The frequencies compared among...