A5102908506- Circular RNAs in diseases
- MicroRNA in disease regulation
- Connexins and lens biology
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Bone Metabolism and Diseases
- Ginseng Biological Effects and Applications
- Congenital heart defects research
- Ion channel regulation and function
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Tryptophan and brain disorders
- ATP Synthase and ATPases Research
- Redox biology and oxidative stress
- Cell death mechanisms and regulation
- RNA Research and Splicing
- Thermal Regulation in Medicine
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Bone health and treatments
- Multiple Myeloma Research and Treatments
- Cancer Mechanisms and Therapy
- Pluripotent Stem Cells Research
- Stress Responses and Cortisol
- Medicinal Plant Pharmacodynamics Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Wuhan Polytechnic University
2025
Jiangnan University
2025
Institute of Hematology & Blood Diseases Hospital
2021-2024
Zhejiang University
2024
Hangzhou Seventh Peoples Hospital
2024
National Clinical Research
2024
Harbin Medical University
2020-2022
N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development pathogenesis. However, the potential involvement of m6A in regulation cardiomyocyte (CM) proliferation cardiac regeneration remains unclear. In this study, we aimed to investigate role modification heart during postnatal adult injury. Methods results: identified downregulation demethylase ALKBH5, an "eraser" that responsible increased methylation, after birth. Notably, ALKBH5...
Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy. Despite the improved understanding of these processes, detailed molecular mechanisms underlying cochlear HC senescence remain unclear. Transcription Factor EB (TFEB), a key regulator genes associated with autophagy lysosomes, crucially affects aging‐related illnesses. However, intricate regulatory networks that influence TFEB activity to be thoroughly elucidated. The findings...
The surfaces of underwater ship hulls and aquaculture equipment, such as fish cages, are highly susceptible to damage from fouling organisms. Although traditional marine antifouling coatings exhibit effective properties, the leaching agents into environment can lead pollution ecological disruption. In this study, we prepared castor oil polyurethane (CO-PU) by reacting with isocyanate. We then incorporated self-synthesized acrylamide-based quaternary ammonium salts (QASs), specifically...
Directed evolution, enzyme design, and effective immobilization have been used to improve the catalytic activity. Dynamic polymers offer a promising platform activity in aqueous solutions. Here, amphiphilic dynamers lipase self-assemble into nanoparticles of 150- 600-nanometer diameter, showing remarkable threefold enhancement In addition, they also demonstrated ability promote reversible refolding partially or completely denatured lipase. The efficiency is completed with its more convenient...
Osteoarthritis (OA) is a leading cause of pain and disability worldwide, which characterized by degenerative inflammatory processes affecting joints surrounding tissues. This study aimed to elucidate the role possible mechanism long non-coding RNA HOX antisense intergenic myeloid 1 variant (HOTAIRM1-1) in development osteoarthritis (OA).The expressions HOTAIRM1-1 miR-125b OA cartilages normal articular were determined. Moreover, human mesenchymal stem cells (MSCs) cultured MSC growth medium...
Hypericin is widely utilized for its precise antidepressant properties, but exact mechanism remains unclear. Gap junctions, which were predominantly expressed in astrocytes the central nervous system, are concerned with pathogenesis of depression. However, role hypericin gap junctional dysfunction depression has rarely been investigated. Here, we found that junctions ultra-structurally broadened chronic unpredictable stress (CUS) rat model depression, while repaired junctions. Suppression by...
The increasing incidence of hepatocellular carcinoma (HCC) is a major challenge worldwide.In the past few years, an number studies have suggested that circular RNAs (circRNAs) play important role in development human tumors, including HCC, but our understanding their function still limited.In this study, we investigated differences expression circRNA MAN2B2 (circMAN2B2) tissues and paired normal tissues.We found knockdown circMAN2B2 HCC cell lines Hep-G2 Huh-7 significantly inhibited...
Lung cancer is one of the most frequently occurring and fatal types worldwide. Cisplatin widely used for chemotherapy non-small cell lung (NSCLC). However, use cisplatin has been met with challenge chemoresistance as a result hypoxia, which common in adult solid tumors principal cause poor patient outcome. In present study, effects hypoxia on response NSCLC A549 line to clinically relevant cytotoxic were evaluated via regulating inducible facor-1α (HIF-1α) p53. Hypoxia exposure upregulated...
ABSTRACT Marine biofouling poses a threat to marine facilities. In this work, quaternary ammonium salt (E54‐QAS) was synthesized from triethylammonium hydrochloride and epoxy resin E‐54, which then incorporated into polyurethane (PU) prepolymer fabricate an antifouling coating. The coating exhibited bonding strength as high 3.12 MPa impact resistance of 90 kg well excellent antibacterial efficiency against Pseudomonas aeruginosa at E54‐QAS content 4.2%. Moreover, the antimicrobial efficacy...
The central role of reactive oxygen species (ROS) in osteoclast differentiation and bone homeostasis prompted us to characterize the redox regulatory system osteoclasts. In this report, we describe expression functional characterization PAMM, a CXXC motif-containing peroxiredoxin 2-like protein expressed marrow monocytes on stimulation with M-CSF RANKL. Expression wild-type (but not C G mutants domain) PAMM HEK293 cells results an increased GSH/GSSG ratio, indicating shift toward more...
Macrophages within adipose tissue play a key role in mediating inflammatory responses that are associated with obesity-related metabolic complications. In an effort to identify novel proteins secreted from adipocytes may negatively regulate macrophage inflammation, we found peroxiredoxin (PRX)-like 2 activated M-CSF stimulated monocytes (PAMM), CXXC-type PRX-like domain-containing redox regulatory protein, is protein potent anti-inflammatory properties. PAMM mature human but not...
Our previous studies showed that prostaglandin E2 (PGE2) promotes hepatoma cell growth and migration, as well invasion; however, the precise mechanism remains elusive. Snail p65 protein levels were detected in human samples with hepatocellular carcinoma (HCC) by immunohistochemistry (IHC) staining. HCC lines (Huh-7 Hep3B) used for vitro experiments. PGE2/Akt/NF-κB pathway was investigated Huh-7 Hep3B cells after treatment PGE2, EP4 receptor (EP4R) agonist, Akt inhibitor, NF-κB respectively,...
Bone mesenchymal stem cells (BMSCs) are an important source of for tissue repair and regeneration; therefore, understanding the mechanisms that regulate cell differentiation in a specific lineage is critical. Runt‑related transcription factor 2 (Runx2) bone‑specific serves role promoting osteogenic differentiation. However, Runx2 protein levels regulated by ubiquitin‑proteasome pathway. Previous research has identified Smad6 can interact with enhance Smurf1‑induced degradation...
Myelin damage and abnormal remyelination processes lead to central nervous system dysfunction. Glial activation-induced microenvironment changes are characteristic features of the diseases with myelin abnormalities. We previously showed that ginsenoside Rg1, a main component ginseng, ameliorated MPTP-mediated in mice, but underlying mechanisms unclear. In this study we investigated effects Rg1 cuprizone (CPZ)-induced demyelination mouse model. Mice were treated CPZ solution (300 mg· kg−1·...