A5100344750- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Nuclear Receptors and Signaling
- Bioactive natural compounds
- Flavonoids in Medical Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Phytochemistry and Biological Activities
- Lysosomal Storage Disorders Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Natural product bioactivities and synthesis
- Inflammation biomarkers and pathways
- Genomics, phytochemicals, and oxidative stress
- Vitamin D Research Studies
- Protein Degradation and Inhibitors
- Vestibular and auditory disorders
- Cholinesterase and Neurodegenerative Diseases
- NF-κB Signaling Pathways
- Neuroscience and Neuropharmacology Research
- Marine Sponges and Natural Products
- Microtubule and mitosis dynamics
Binzhou University
2019-2024
Binzhou Medical University
2019-2024
Sun Yat-sen University
2020-2024
Third Affiliated Hospital of Sun Yat-sen University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2019
Emerging evidence has shown that cinobufagin, as an active ingredient of Venenum Bufonis, inhibits tumor development. The aim this study was to investigate the inhibitory effects cinobufagin on A375 human malignant melanoma cells. MTT and colony formation assays showed significantly inhibited cell proliferation formation. Additional studies demonstrated markedly increased levels ATM serine/threonine kinase (ATM) checkpoint 2 (Chk2) decreased division cycle 25C (CDC25C), cyclin-dependent 1...
The development of neuroprotective agents has important clinical significance. Bavachin is a flavonoid compound in Psoralea corylifolia, which multiple biological activities, however its effect and molecular mechanism remain unclear. We found that bavachin inhibited neuroinflammation also exerted significant antioxidative stress effects. Furthermore, we neuronal protective anti-apoptotic Further studies showed increased Bcl-2 expression, while Bax the decrease mitochondrial membrane...
Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss (SHL) and Meniere's disease (MD). However, different glucocorticoid administration methods may have a significant impact on outcomes. This study aimed to investigate effects disease. In this study, were administered orally 18 patients, by retroauricular injection 15 patients intratympanic patients. White blood cell (WBC) count, serum K+, fasting plasma glucose (FPG), body temperature, heart rate...
Neuroinflammation and oxidative stress are key factors leading to neuronal injury. In this study, we investigated the role of S32, a novel 3-acetylaminocoumarin compound, in ameliorating injury induced by neuroinflammation vitro vivo. First, found that S32 reduced expression levels p-P65 p-P38, inhibited nuclear translocation P65, lowered pro-inflammatory LPS-induced BV2 cells, which indicated had an antineuroinflammatory effect. Second, cell culture medium was used as conditioned establish...
The accumulation of misfolded a-synuclein is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha-synuclein causes unresolved. Several studies have supported the involvement dynein, major motor for retrograde axonal transport alpha-synuclein-dependent neurodegeneration, especially nigrostriatal system. Therefore, we examined dyneins transgenic mice that overexpress human A53T recapitulate key features a PD-like neuronal...