A5033185443- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Constructed Wetlands for Wastewater Treatment
- Wastewater Treatment and Nitrogen Removal
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Abdominal Trauma and Injuries
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Microplastics and Plastic Pollution
- Ubiquitin and proteasome pathways
- Single-cell and spatial transcriptomics
- Metastasis and carcinoma case studies
- Congenital Anomalies and Fetal Surgery
- Colorectal Cancer Treatments and Studies
- Composting and Vermicomposting Techniques
- Peroxisome Proliferator-Activated Receptors
- Histone Deacetylase Inhibitors Research
Fudan University Shanghai Cancer Center
2019-2025
The University of Texas Health Science Center at Houston
2025
Kunming University of Science and Technology
2021-2024
Shanghai Cancer Institute
2024
Kunming Metallurgical Research Institute
2024
Shanghai Medical College of Fudan University
2023
Shanghai East Hospital
2019
Tianjin Medical University Cancer Institute and Hospital
2018
The First Affiliated Hospital, Sun Yat-sen University
2014-2017
Zhongshan Hospital
2014-2017
Background: Hepatocellular carcinoma (HCC) is one of the most leading causes cancer-related mortality worldwide.Immune checkpoint inhibitors (ICIs) have been proved to be beneficial for advanced HCC.Tumor mutational burden (TMB) an important predictor efficacy ICIs.However, genetic landscape Chinese HCC patients and association between TMB frequently mutated genes remain unclear.Methods: Whole-exome sequencing data 369 liver tumors from Cancer Genome Altas (TCGA) next generation (NGS) 657...
The genomic alterations of intrahepatic cholangiocarcinoma (ICC) in the Chinese population have not been fully revealed. Molecular profiling may provide a reference for clinical management, especially targeted therapy.A retrospective study was conducted 122 ICC patients. All patients' samples underwent next-generation sequencing (NGS), which analyzed 417 genes. genetic characteristics, management and therapeutic responses were analyzed.The most commonly mutated genes TP53 (34%), KRAS (25%)...
Abstract Increasing evidence has shown that Chinese herbal medicine (CHM) promising therapeutic effects in colorectal cancer (CRC); however, the active ingredients and potential targets remain unclear. In this study, we aimed to investigate relative molecular of herbs have been found effective treating metastatic CRC (mCRC) based on clinical data network pharmacology. multivariate analysis CHM resulted an independent prognostic factor. The hazard ratio was 0.103 (95% confidence interval =...
Members of the tripartite motif (TRIM)-containing protein family have been found to be involved in progression hepatocellular carcinoma (HCC). TRIM14 exerts a promotive impact on several cancers. This study aimed explore function and mechanism HCC. expression HCC tissues cell lines was detected. The overexpression or knockdown model established lines. Cell Counting Kit-8 (CCK-8) assay, flow cytometry, Transwell RT-PCR, Western blot, immunofluorescence were performed verify influence...
Abstract In silico perturbation models, computational methods which can predict cellular responses to perturbations, present an opportunity reduce the need for costly and time-intensive in vitro experiments. Many recently proposed models high-dimensional responses, such as gene or protein expression perturbations knockout drugs. However, evaluating performance has largely relied on metrics R 2 , assess overall prediction accuracy but fail capture biologically significant outcomes like...
Abstract The standard regimen of gemcitabine combined with cisplatin offers limited clinical benefits in the treatment advanced intrahepatic cholangiocarcinoma (ICC) due to intrinsic or acquired resistance. Currently, effective biomarkers predict and improve chemotherapy resistance ICC are lacking. Here, it is reported that a long non‐coding RNA (lncRNA), PAX8‐AS1 , reduces efficacy chemotherapeutic drugs. Mechanistically, activates NRF2 by binding p62, thereby promoting GPX4 transcription,...
Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, expression pattern and biological role 4 pancreatic cancer have never investigated. In this study, we found that both messenger ( p < 0.001) protein level were decreased significantly specimens compared with their adjacent normal tissues. Overexpression cells inhibited cell growth motility vitro, while suppressing promoted...
Background/Aims: The Xi-Huang (XH) formula has been used for breast cancer treatment in traditional Chinese medicine (TCM) since 1740. In this study, we show that, XH extract could suppress the growth of cells vitro and vivo, that it preferentially inhibits cell estrogen receptor positive (ER+) cells. Presently, little is known about potential mechanism our studies aim to elucidate its treatment. Methods: Network-based systems biology molecular docking analyses were performed predict...
Intrapancreatic accessory spleen is an uncommon congenital abnormality of the with no indication for surgical intervention. Among few cases reported, IPAS coexisted a normal spleen. We here report first case arising couple years after splenectomy appearance endocrine tumor pancreas. A 62-year-old female presented one-week history left upper quadrant discomfort. She had treatment hypersplenism caused by cirrhotic portal hypertension two before this admission. Her physical examination was...
Regardless of the improvements in diagnostic and therapeutic methods, clinical outcomes hepatocellular carcinoma (HCC) patients remain poor. Although accumulating evidence indicates that lncRNAs (long noncoding RNAs) are essential within control tumorigenesis metastasis cancer, underlying mechanisms largely unknown. This work explored pattern expression functional significance a newly found lncRNA, Ewing sarcoma-associated transcript 1 (EWSAT1), HCC metastasis. The results indicated EWSAT1...
Background and Objectives The Sendai consensus guidelines (SCG) Fukuoka (FCG) have been examined for their roles in predicting advanced neoplasia (AN) pancreatic cystic neoplasm (PCN) patients with mixed results. We aim to evaluate the utilities of both a Chinese cohort preoperatively diagnosed mucinous PCNs. Methods One hundred ninety‐seven who underwent resections from 2008 2015 Zhong Shan Hospital, Fudan University suspected PCNs were retrospectively reviewed. Receiver operating...
Liver hepatocellular carcinoma (LIHC) is a lethal cancer. This study aimed to identify the N6 -methyladenosine (m6 A)-targeted long non-coding RNA (lncRNA) related LIHC prognosis and develop an m6 A-targeted lncRNA model for prediction in LIHC.The expression matrix of mRNA was obtained, differentially expressed (DE) mRNAs lncRNAs between tumor normal samples were identified. Univariate Cox pathway enrichment analyses performed on prognosis-related lncRNAs. Prognostic analysis, immune...
The relative risk and benefits of Laparoscopic liver resection (LLR) are still controversial. This study aimed to evaluate perioperative survival outcomes for three primary malignant tumors related following LLR. Data from Homogeneous-High-Volume-Expert-Centers were collected. Multivariable logistic regression analysis was performed the association between LLR, major complications defined as Clavien-Dindo Classification grade ≥ II. Cox proportional hazards used explore impact LLR on tumor...
Herein, an aerobic denitrifier, RC-15, was added to a vertical-flow constructed wetland (VFCW) promote denitrification, and the presence of functional genes microbial communities investigated at different VFCW depths. With from 79~103 days (during stable operation), average NO3--N TN removal rates were 83.63%±2.58% 74.12%±1.90%, respectively, which higher than those control (67.92±2.2 54.52±2.5%). Quantitative PCR (qPCR) showed that in upper region, napA (catalytic reduction NO2--N) nirK...
489 Background: Immune checkpoint inhibitors plus chemotherapy had demonstrated important therapeutic advantages in biliary tract cancers (TOP-AZ and Keynote-966). At present the data of gallbladder carcinoma (GBC) is blank condition almost, effectiveness remains to be improved. Further, addition bevacizumab PD-1 has improved clinical results carcinomas, such as hepatocellular carcinoma, for which options have been limited. This study intended explore safety efficacy sintilimab combined with...
Objective: To investigate the effects of different expression monoacylglycerol lipase (MAGL) in tumor-associated macrophages (TAMs) with proliferation MHCC97H human liver cancer cells vivo and its mechanism. Methods: Human peripheral blood-derived monocyte was induced to differentiate into M2-type TAMs identified by flow cytometry. The co-culture model established, MAGL detected qRT-PCR. plasmid transfection. ELISA qRT-PCR used detect mRNA levels secretion inflammatory factors cells....
Objective To investigate the clinical characteristics and surgical outcomes of pancreatic acinar cell carcinoma (PACC). Methods The follow up data PACC patients treated with surgery in Zhongshan Hospital Fudan University between 1999 2012 were analyzed retrospectively. Results A total 16 identified including 13 male 3 female patients. The age ranged from 38 to 71 an average 57 years old. Six presented as abdominal pain, while low back pain patients, distention 2 emaciation...
Objective To investigate the risk factors of delayed gastric emptying after pancreaticoduodenectomy (PD) for periampullary carcinoma. Methods The clinical data 96 carcinoma patients who received PD with or without pylorus preservation at Zhongshan Hospital Fudan University from October 2010 to September 2013 were retrospectively analyzed. The associated univariate and multivariate analysis done using chi-square test Logistic regression model respectively. Results A total 17 had...
Objective To promote the diagnostic accuracy of intrapancreatic accessory spleen (IPAS).Methods The clinical data 10 cases IPAS admitted in Fudan University Zhongshan Hospital from Apr 2005 to Dec 2013 were retrospectively analyzed.Results There ten confirmed pathologically.Only 1 was diagnosed correctly and definitely with preoperatively.The other 9 misdiagnosed benign or malignant pancreatic tumors,including nonfunctional neuroendocrine neoplasms 5 cases,pancreatic cancers 3 intraductal...