A5105404983- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cardiovascular and Diving-Related Complications
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Cancer-related molecular mechanisms research
- Vascular Tumors and Angiosarcomas
- MRI in cancer diagnosis
- Circular RNAs in diseases
- Cell Image Analysis Techniques
Shandong Tumor Hospital
2014-2024
Shandong First Medical University
2014-2024
First Hospital of Jilin University
2012-2023
Jilin University
2012-2023
Academy of Medical Sciences
2021-2023
Simcere Pharmaceutical (China)
2021
Jilin Agricultural University
2020
Shandong University
2016-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
China Jiliang University
2009-2011
Abstract Purpose The residual cancer burden index (RCB) was proposed as a response evaluation criterion in breast patients treated with Neoadjuvant Chemotherapy (NAC). This study evaluated the relevance of RCB replase-free survival (RFS). Methods clinical data 254 who received NAC between 2016 and 2020 were retrospectively collected. relationship clinicopathologic factors RFS using Cox proportional hazards regression models. estimates determined by Kaplan–Meier(K-M) analysis compared...
MicroRNAs (miRNAs) have been documented as playing important roles in diverse biological processes including tumorigenesis. However, the function and mechanism of miR-326 gastric cancer are still unknown. The aim this study is to identify role clarify regulation Fascin1 (FSCN1) by miR-326.The expression levels were detected samples cell lines real-time PCR. clinical prognostic significance patients analyzed. Furthermore, on tumor growth mobility explored through MTT, colony formation,...
In ovarian cancer patients, chemotherapy resistance is the principal factor restricting long-term treatment. Paclitaxel (Pac) has been previously reported to be a ligand Toll-like receptor 4 (TLR4). It was determined that TLR4 signaling divided into following two pathways: Myeloid differentiation 88 (MyD88)-dependent and MyD88-independent. The present study investigated effect of ligation by Pac in MyD88-positive (MyD88+) MyD88-negative (MyD88-) human cell lines. An RNA interference...
Remodeling spacing factor 1 (RSF-1/HBXAP) has been linked to a variety of cancer types, however, its roles and the therapeutic potential are not clear in cervical cancer.
We describe a case of recurrent glioblastoma treated with anlotinib in this report. The patient was administered 12 mg p.o. once every day (days 1-14, 21-day cycle) (anlotinib clinical study NCT04004975) and oral temozolomide chemotherapy 100 mg/m2 1-7, days 15-21, 28-day cycle; cycles). After 2 months therapy, the achieved partial response that has been maintained for >17 follow-up. Molecular characterization confirmed presence TERT promoter mutation, wild-type IDH1/2, an FGFR3-TACC3...
Abstract Objectives The purpose of this study was to investigate the prognostic significance radiomics in conjunction with hematological parameters relation overall survival (OS) individuals diagnosed esophageal squamous cell carcinoma (ESCC) following definitive chemoradiotherapy (dCRT). Methods In retrospective analysis, a total 122 patients locally advanced ESCC were included. These randomly assigned either training cohort ( n = 85) or validation 37). group, least absolute shrinkage and...
Pancreatic cancer is one of the most lethal types cancer, and curative resection only applicable to potentially limited cases due early metastasis local invasion. This study reports influence CXCL12 its receptor CXCR4 on progression pancreatic highlights correlation between CXCL12/CXCR4 axis organ-specific adenocarcinoma (PAC). A total 34 patients with participated in current study. The expression cancerous tissues, paracancerous normal pancreas lymph nodes surrounding were investigated...
Introduction Glucosylceramide synthase (GCS) is one enzyme that provides a major route for ceramide clearance. Recent evidence has indicated an important role GCS in multidrug resistance (MDR) tumors. Doxorubicin (DOX)can modulate the expression of leukemia and ovary cell lines. However, few studies have investigated their relationship breast cancer; Methods We collected 84 excision biopsies from patients with invasive ductal cancer whom 33 had undergone preoperative chemotherapy....
We evaluated the safety and effectiveness of transcatheter patent foramen ovale (PFO) closure for treatment migraine in a Chinese population. This non-randomized clinical trial enrolled 258 consecutive substantial or severe migraineurs with right-to-left shunt (RLS) (grade II-IV) grouped subjects according to their election refusal PFO closure. Migraine was diagnosed International Classification Headache Disorders III-beta using Impact Test-6 (HIT-6). In total, 241 participants (125 group...
Non-small-cell lung cancer (NSCLC) accounts for the most cases in clinical patients. Patients with NSCLC are often diagnosed advanced stage and frequently infected gram-negative bacteria. Pulmonary infection bacteria is frequent postoperative complication While accumulating evidence indicate an involvement of progression, underlying mechanisms remain largely unknown. Herein, we explored effect on tumor progression using cells from We observed that predicted stages decreased time interval to...
Abstract Aims This study aimed to investigate changes in dynamic cerebral autoregulation (dCA), 20 stroke‐related blood biomarkers, and autonomic regulation after patent foramen ovale (PFO) closure severe migraine patients. Methods Patent patients, matched non‐PFO healthy controls were included. dCA evaluated each participant at baseline, within 48‐h 30 days PFO migraineurs. A panel of biomarkers was detected pre‐surgically arterial‐and venous blood, post‐surgically the arterial Results...
There is a growing amount of research that highlights the significant connection between development colitis and both metabolic imbalance inflammatory response. Tagatose, an inherent sweetening agent alternative to sugar, plays crucial role in biosynthesis several chemicals pathways living organisms. However, specific biochemical mechanism via which tagatose hinders still not understood. According recent study, safeguarding integrity tight junctions inside intestinal mucosal barrier....
We present a case of single endometrial metastasis from breast invasive ductal cancer. This was unique because the immunohistochemical staining negative for human epidermal growth factor receptor 2/neu and estrogen progesterone receptors, positive cytokeratin 5/6 in primary metastatic tumor cells. No gross evidence observed other sites. identified 12 cases metastases to endometrium carcinoma series reports literature between 1985 2014. review indicated that hormone receptor-positive lobular...
Gastric cancer is the second most prominent cause of mortality in world. This study was designed to identify possible use si-RNA-mediated PDLIM5 gene silencing as a therapeutic tool for gastric cancer. Expression levels were detected several cell lines using Western blot and qRT-PCR. We found highly expressed all cultured lines. Small interfering RNA (si-RNA) then employed knock down expression MGC80-3 cells. Knockdown significantly inhibited proliferation colony formation. Moreover, absence...
Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was compare proteomic profiles between adrenocortical carcinomas (ACC) normal tissues in order identify potential ACC. protein samples from 12 their paired adjacent were profiled two-dimensional electrophoresis; differentially expressed proteins identified by mass spectrometry. Expression patterns three differently calreticulin,...
Toll-like receptor (TLR4) 4 is present in numerous cell types and serves as the first point of defense innate immune system. Single-nucleotide polymorphisms (SNPs) are a number TLR genes have been associated with various infection inflammation disorders. Asp299Gly Thr399Ile, TLR4 SNPs, tumor progression. In study, cases ovarian cancer were analyzed regards to Thr399Ile gene. Genotype analysis was performed using DNA from tissue samples stage I-IV patients cancer. extracted by pyrosequencing...
Intramuscular myxoma (IMM) as a rare soft-tissue tumor arising from the muscles is completely benign. When IMM accompanies malignance, it may be misdiagnosed muscle metastasis, and for this extremely concurrence, subsequent treatment would vary accordingly. The current study presents, to best of our knowledge, first case non-small cell lung cancer (NSCLC) concomitant with mimicking skeletal metastasis. A 64-year-old female was hospitalized history chest discomfort right lumbar pain that had...