A5103090516- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Caveolin-1 and cellular processes
- Heat shock proteins research
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- RNA Research and Splicing
- ATP Synthase and ATPases Research
- Lung Cancer Research Studies
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Polyamine Metabolism and Applications
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Endoplasmic Reticulum Stress and Disease
- Colorectal Cancer Treatments and Studies
Central South University
2016-2025
Second Xiangya Hospital of Central South University
2016-2025
University of South China
2025
Xiangshan County First People's Hospital
2025
Jinan Central Hospital
2023
Abstract Everolimus is a kind of mammalian target rapamycin (mTOR) inhibitors. Activated mitogen-activated protein kinase interacting kinases/eukaryotic translation initiation factor 4E (MNK/eIF4E) axis plays crucial role in resistance to non-small cell lung cancer (NSCLC). The eIF4E phosphorylation increased by mTOR inhibitors mainly mediated MNKs. However, the mechanisms are poorly understood. Recently, extensive reprogramming miRNA profiles has also been found after long-term inhibitor...
Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck region, which frequently occurs in Southeast Asia, especially south China. It known that mammalian target rapamycin (mTOR) pathway plays central role regulating cellular functions, including proliferation, growth, survival, mobility, angiogenesis. Aberrant expression mTOR signaling molecules has been found many types cancer. However, whether alterations p-Akt, p-p70S6K p-4EBP1 protein are associated with...
Abstract Bromodomain containing 7 (BRD7) was identified as a nuclear transcriptional regulatory factor. BRD7 functions tumor suppressor in multiple cancers, including nasopharyngeal carcinoma (NPC). In this study, we reported novel mechanism of NPC progression. We demonstrated that the expression miR-141 remarkably increased tissues and negatively correlated with survival rate patients. Decreased levels miR-141, primary, precursor mature forms were found BRD7-overexpressing HEK293, 5-8F HNE1...
// Wei Dang 1, 2, 3, * , Zailong Qin Songqing Fan 4 Qiuyuan Wen Yuanjun Lu 3 Jia Wang Xuemei Zhang Lingyu He 5 Qiurong Ye Qun Yan 6 Guiyuan Li Jian Ma 1 Hunan Cancer Hospital and the Affiliated of Xiangya School Medicine, Central South University, Changsha, Hunan, China 2 Research Institute, Key Laboratory Nonresolving Inflammation Cancer, Carcinogenesis Ministry Health, Invasion Education, Department Pathology, The Second Xi'an Children's Hospital, Xi'an, Shaanxi, Clinical Laboratory, These...
The mammalian target of rapamycin (mTOR) is a potentially important therapeutic in broad range cancer types. mTOR inhibitors such as and its analogs (rapalogs) have been proven effective anticancer agents non-small cell lung (NSCLC), whereas they strongly enhance phosphorylation eukaryotic translation initiation factor 4E (eIF4E) activation Akt, which cause resistance to mTOR-targeted therapy after an initial response. Rapamycin induces eIF4E by activating MAPK-interacting kinases (Mnks),...
Nuclear localization of β-catenin is essential for the progression various human cancers via transcriptional upregulation downstream genes. The MAP kinase interacting serine/threonine (MNK)-eukaryotic translation initiation factor 4E (eIF4E) axis has been reported to activate Wnt/β-catenin signaling, and CGP57380, an inhibitor MNK kinases, inhibits proliferation multiple cancers. In this study, we showed that signaling (including β-catenin, cyclin D1, c-Myc, MMP-7) p-eIF4E expression were...
Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor rare throughout most of the world but common in Southeast Asia, especially Southern China. The phosphorylation eukaryotic translation initiation factor 4E (eIF4E) by MAP kinase-interacting kinases (Mnk) on Ser-209 promotes cellular proliferation, survival, transformation metastasis. However, whether alterations expression p-eIF4E p-Mnk1 protein are associated with clinicopathologic/prognostic implication for NPC has not been...
Abstract Lipid raft proteins have been confirmed to be important in cell signal transduction. Some reports shown that the aberrant expression of lipid is associated with malignant phenotypes some cancers. However, role protein flotillin-2 (Flot-2) nasopharyngeal carcinoma (NPC) remains comprehensively characterized. Here, overexpression Flot-2 NPC tissues and lines was detected by immunostaining found positively metastasis. Furthermore, inhibiting impaired malignancy highly metastatic line...
Breast cancer, the second most common cancer worldwide, is leading cause of cancer-associated mortality in women, accounting for ~15% all mortalities women. The development, local invasion and metastasis breast are associated with dysregulation mutation numerous genes epigenetic mechanisms, including coding RNA non‑coding RNA, such as microRNAs (miRs/miRNAs). Previous studies have shown a dual‑faced role miR‑125b cancer. In present study, total 221 paraffin‑embedded 49 non‑cancerous tissue...
Abstract Purpose G3BP1 is an RNA‐binding protein and plays roles in regulating signaling pathway. YB‐1 a DNA/RNA binding encoded by YBX1 gene. Phosphorylated AKT (p‐AKT) acts as pivotal molecule PI3K/AKT drives stress granules (SGs) formation activating translation under diverse conditions. SGs are involved many different metabolic pathways which may include PI3K/AKT/mTOR. So far, there has been no report on the relationship between expression of G3BP1, p‐AKT, YB1 clinicopathological...
The Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway, which is dysregulated in various cancers, controls the assembly eukaryotic translation initiation factor 4F (eIF4E) complex. However, whether aberrant expression phosphorylated (p-Akt), mTOR (p-mTOR) and eIF4E (p-eIF4E) associated with clinicopathological characteristics surgically resected non-small cell lung cancer (NSCLC) has been rarely reported. Here, we investigated p-Akt, p-mTOR p-eIF4E proteins NSCLC by...
YAP1 is a well-known core effector of the Hippo pathway in tumors, but its potential role osimertinib resistance remained unexplored.Our study provides evidence that acts as potent promoter resistance.By inhibiting with novel inhibitor, CA3, and combining it osimertinib, we observed significant suppression cell proliferation metastasis, induction apoptosis autophagy, delay emergence resistance.Interestingly, CA3 combined executed anti-metastasis pro-tumor part through...
We previously reported that expression of Flotillin 2 (Flot-2), a protein isolated from caveolae/lipid raft domains, increased significantly in nasopharyngeal carcinoma (NPC) compared with normal tissues. Signal transduction through epidermal growth factor receptors (EGFR) and Flot-2 play an important role cancer development, but their precise lung has not been investigated. In this study, we have investigated the correlation between EGFR, which increase non-small cell (NSCLC) patients...
MicroRNA (miRNA) dysregulation has been identified in several carcinomas, including non-small cell lung cancer (NSCLC), and is known to play a role the development progression of this disease. We initially conducted miRNA microarray analysis, which revealed that MNK inhibitor CGP57380 increased expression miR-150-3p. A similar analysis was performed using data from The Cancer Genome Atlas (TCGA). Cell proliferation, colony formation migration assays were validated A549 H157 cells treated...
Nasopharyngeal carcinoma (NPC) is prevalent in South East Asia and Southern China particularly, despite the reported 5-year survival ratio relative higher than other deadly cancers such as liver, renal, pancreas cancer, lethality characterized by high metastatic potential early stage recurrence rate after radiation treatment. MicroRNA-29c was found to be down-regulated serum well tissue of nasopharyngeal tissue. In this study, we accidentally that transfection pre-miR-29c or miR-29c mimics...
Breast cancer has become the leading cause of cancer-related death among women. A large number patients resistant to drug chemotherapy. Paclitaxel (Taxol) is an effective chemotherapeutic agent used treat patients. Taxol been widely in human malignancies including breast because it can stabilize microtubules resulting cell by causing arrest during G2/M phase cycle. Pro-apoptotic Bcl-2 antagonist killer 1 (Bak) plays important role Taxol-induced apoptosis cancer. In our present study, we...
HSP60 and its partner HSP10 are members of heat shock proteins (HSPs) family, which help mitochondrial protein to fold correctly. Mcl-1, a member the Bcl-2 plays crucial role in regulation cell apoptosis. Aberrant expression HSP10, Mcl-1 is involved development many tumors.To examine association between clinicopathological features non-small lung cancer (NSCLC).Tissue microarrays including 53 non-cancerous tissues (Non-CLT) 354 surgically resected NSCLC were stained with anti-HSP10,...
HSP60 is a heat shock proteins (HSPs) family member and help mitochondrial protein to fold correctly. Survivin one of the inhibitors apoptosis member, which plays significant part in cancer progression. They were capable forming HSP60-survivin complexes involved development various tumors.The Cancer Genome Atlas (TCGA) database demonstrated that survivin their correlation on mRNA expression level with OSCC patients. Besides, was studied utilizing immunohistochemistry tissue microarrays (TMA)...