A5100454036- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Geochemistry and Geologic Mapping
- IL-33, ST2, and ILC Pathways
- Heavy metals in environment
- Liver Diseases and Immunity
- Tannin, Tannase and Anticancer Activities
- Receptor Mechanisms and Signaling
- Advanced Welding Techniques Analysis
- Pharmacological Receptor Mechanisms and Effects
- Cancer Immunotherapy and Biomarkers
- Metal Forming Simulation Techniques
- Mine drainage and remediation techniques
- Microstructure and mechanical properties
- Sleep and Wakefulness Research
- Metallurgy and Material Forming
- Diet and metabolism studies
- Aluminum Alloy Microstructure Properties
- Welding Techniques and Residual Stresses
- Neonatal Respiratory Health Research
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Characterization and Applications of Magnetic Nanoparticles
- Magnesium in Health and Disease
Central South University
2015-2025
Xiangya Hospital Central South University
2012-2025
Third Xiangya Hospital
2021-2024
Capital Medical University
2023
UCLA Medical Center
2015-2020
Harbor–UCLA Medical Center
2015-2020
Tianjin Children's Hospital
2019
PharmacoGenetics (China)
2007-2018
The Lundquist Institute
2013-2015
Los Angeles Medical Center
2013
Asthma is a major public health hazard worldwide. Its transgenerational inheritance has been inferred from epidemiological studies. More recently, using nicotine as proxy for maternal smoking, we have demonstrated that an asthma-like phenotype can be inherited by rat offspring up to two generations, i.e., multigenerationally, after the initial intrauterine exposure. We hypothesized asthma transmission following perinatal exposure not restricted F 2 generation, but it also extends subsequent...
Both preclinical and epidemiology studies associate β-adrenoceptors-blockers (β-blockers) with activity against melanoma. However, the underlying mechanism is still unclear, especially in acral In this study, we explored effect of propranolol, a non-selective β-blocker, on A375 melanoma cell line, two primary lines (P-3, P-6) mice xenografts. Cell viability assay demonstrated that 50μM-400μM propranolol inhibited concentration time dependent manner an IC50 ranging from 65.33μM to 148.60μM...
Iron status indicators are closely associated with the occurrence of advanced liver fibrosis.
Background & Objective Selenium was one of the essential trace elements that played a pivotal role in human health. Although previous studies have investigated relationship between selenium and non-alcoholic fatty liver disease (NAFLD) fibrosis, these findings were still inconclusive. Our study aimed to explore association blood level NAFLD advanced fibrosis diagnosed by vibration controlled transient elastography (VCTE) US adults.Methods All data extracted from National Health Nutrition...
Pulmonary hypertension (PH) secondary to lung fibrosis belongs WHO Group III, one of the most common subgroups PH; however, it lacks effective treatment options. Cholinesterase inhibitor donepezil (DON) has been shown effectively improve I PH. However, its effects on III PH are unknown.
Aspirin is a frequently prescribed drug for primary and secondary prevention of myocardial infarction, stroke cardiovascular death. However, aspirin resistance may affect up to 45% the population. Little known on role genetic factors that contribute or augmented response in different human populations.In large sample nonsmoker, medication-free healthy volunteers from mainland China (n = 323; age: 22.1 +/- 2.0 years) (mean standard deviation), we determined frequency polymorphisms...
Abstract Lipid raft proteins have been confirmed to be important in cell signal transduction. Some reports shown that the aberrant expression of lipid is associated with malignant phenotypes some cancers. However, role protein flotillin-2 (Flot-2) nasopharyngeal carcinoma (NPC) remains comprehensively characterized. Here, overexpression Flot-2 NPC tissues and lines was detected by immunostaining found positively metastasis. Furthermore, inhibiting impaired malignancy highly metastatic line...
Abstract Background Diagnosis and intervention of prediabetes is an emerging method for preventing diabetic progression complications. Periodontitis has been reported to strongly correlate with the dysregulation glucose metabolism. Nonetheless, relationship between periodontal status prevalence as well its prognosis remains elusive. This study aimed investigate association periodontitis furtherly explore all-cause mortality different among patients prediabetes. Methods The dateset from...
The clinical efficacy of valproic acid (VPA) varies greatly among epileptic patients. To find the potential genetic factors related to VPA responses, pharmacogenetics study was conducted.Two hundred and one Chinese Han patients who were treated by for at least 1 year recruited. Up 24 SNPs in 11 candidate genes that correlate with metabolism, transport or target genotyped.Three SNPs, rs1731017 (ABAT), rs2304016 (SCN2A) rs1054899 (ALDH5A1) found associated responses p-values 0.003, 0.007...
Asthma is a chronic inflammatory disease of the airways, with complex signaling pathways involved in its pathogenesis. It was reported that paeonol attenuated airway inflammation ovalbumin (OVA)-induced mice. Therefore, it importance to further investigate underlying mechanism. BALB/c mice were challenged OVA for asthma model, which validated by changed levels IL-4, IFN-γ, and IgE. The elevation IL-4 decreasing IFN-γ significantly middle (p<0.05) or high (p<0.01) dose groups compared group....
Metabolic dysfunction-associated fatty liver disease (MAFLD) presently poses a threat to approximately 24% of the global population. The consumption healthy diets rich in an abundant assortment vegetables has been scientifically validated mitigate progression MAFLD. However, it remains uncertain whether all categories confer benefits for objective this study is investigate impact different types on MAFLD, aiming provide scientific basis developing more appropriate dietary recommendations...
In a rat model, downregulation of homeostatic mesenchymal peroxisome proliferator-activated receptor-γ (PPAR-γ) signaling following perinatal nicotine exposure contributes to offspring asthma, which can be effectively prevented by concomitant administration PPAR-γ agonist rosiglitazone (RGZ). However, whether exposure-induced asthma reversed is not known. We hypothesized that would RGZ. Pregnant dams received either placebo or from embryonic day 6 until term. Following spontaneous delivery...
Clinically, asthma in children under 5 years old is estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing infants. One hundred forty-five infants 3-year hospitalized with respiratory diseases were enrolled into this study. Patients followed up one-year period after being discharged from hospital and were, then, divided group non-recurrent based on whether there was or not. Wheezing specifically...
Background: Magnesium, the fourth most abundant mineral nutrient in our body, plays a critical role regulating ion channels and energy generation, intracardiac conduction, myocardial contraction. In this study, we assessed association of admission serum magnesium level with all-cause in-hospital mortality critically ill patients acute infarction (AMI). Methods: Clinical data were extracted from eICU Collaborative Research Database (eICU-CRD). Only for first intensive care unit (ICU) each...
The aim of this study was to investigate the role SNPs genes involved in glucocorticoid pathway development steroid resistance patients with primary nephrotic syndrome.Sequenom MassARRAY method used sequence 25 SNP genotypes 154 patients. frequency distribution compared between steroid-sensitive syndrome and those steroid-resistant syndrome.NR3C1 rs6196 G allele carriers had a decreased risk that A carriers. presence rs10052957 rs258751 alleles could reduce incidence allele. Haplotype...
Objectives A multitude of physical and mental challenges are being faced in the population with Co-morbid Insomnia Sleep Apnea (COMISA). Unfortunately, research about clinical characteristics management COMISA based on quantitative evidence is lacking.