A5088537088- Bone Tissue Engineering Materials
- Magnesium Alloys: Properties and Applications
- Graphene and Nanomaterials Applications
- High Entropy Alloys Studies
- Hydrogen Storage and Materials
- Orthopaedic implants and arthroplasty
- Titanium Alloys Microstructure and Properties
- Dental Implant Techniques and Outcomes
- Trace Elements in Health
- ATP Synthase and ATPases Research
- Sphingolipid Metabolism and Signaling
- 3D Printing in Biomedical Research
- Cellular and Composite Structures
- Bone Metabolism and Diseases
- Surface Treatment and Coatings
- Bone fractures and treatments
- Microstructure and mechanical properties
- Glycosylation and Glycoproteins Research
- MXene and MAX Phase Materials
- Heavy Metal Exposure and Toxicity
- Aluminum Alloys Composites Properties
Peking University Third Hospital
2020-2025
Peking University
2020-2025
Ministry of Education of the People's Republic of China
2022-2024
Kangnam University
2003
Laser powder bed fusion (L-PBF) of magnesium (Mg) alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects. However, one key technical difficulties lies in poor L-PBF process performance Mg, contributed by high susceptibility oxidation, vaporization, thermal expansion, attachment etc. This work investigated influence energy input scanning strategy on formation quality using WE43 powder,...
The effects of pore size in additively manufactured biodegradable porous magnesium on the mechanical properties and biodegradation scaffolds as well new bone formation have rarely been reported. In this work, we found that high temperature oxidation improves corrosion resistance scaffold. And characteristics scaffolds, formation, were investigated using with three different sizes, namely, 500, 800, 1400 μm (P500, P800, P1400). We discovered P500 group much better than those other two groups....
Reconstruction of subarticular bone defects is an intractable challenge in orthopedics. The simultaneous repair cancellous defects, fractures, and cartilage damage ideal surgical outcome. 3D printed porous anatomical WE43 (magnesium with 4 wt% yttrium 3 rare earths) scaffolds have many advantages for repairing such including good biocompatibility, appropriate mechanical strength, customizable shape structure, biodegradability. In a previous investigation, we successfully enhanced the...
Zinc (Zn) is a bioabsorbable metal that shows great potential as an implant material for orthopedic applications. Suitable concentrations of zinc ions promote osteogenesis, while excess cause apoptosis. As result, the conflicting impacts Zn
Abstract Addressing the challenge of balancing rapid degradation and insufficient bio‐regenerative capabilities in biodegradable magnesium (Mg) alloys for bone repair is a significant endeavor. In this study, influence Scandium (Sc) content on microstructure, strength, degradation, cytotoxicity, angiogenesis, osteogenesis Mg‐4Yttrium(Y)‐xSc alloy system investigated, novel Mg‐4Y‐2.25Sc (wt.%) that significantly inhibits promotes regeneration successfully developed. This achievement...
As a biodegradable material, magnesium alloy has modulus similar to that of bone, and given the biological activity its degradation products, it potential be bone grafting material. Oxidation heat treatment is very effective passivation method may reduce rate degradation. increases rare earth oxide content scaffold as well corrosion resistance scaffold. The overall cytotoxicity as-printed scaffolds (APSs) oxidation heat-treated (OHSs) showed OHSs accelerated cell proliferation. In apoptosis...
Only a few studies have examined how pore geometry affects the mechanical characteristics, biological behavior, and degradation of additively manufactured biodegradable porous magnesium. In this work, effects on qualities, degradation, behavior were investigated using three typical architectures with same porosity. The structures found to satisfy bone tissue engineering requirements because they had sufficient resistance tunable compressive characteristics. All types magnesium alloy...
We designed and fabricated biodegradable, bioactive mechanically robust porous scaffolds composed completely of biological materials, which are promising as a new candidate for skull defect repair.
The mammalian orosomucoid-like gene family (ORMDL), containing ORMDL1, ORMDL2, and ORMDL3, is the important regulator of sphingolipid metabolism, which relevant to cell growth, proliferation, migration, invasion. Since role ORMDL1 in cancers remained unclear, main purpose our study was explore expression patterns prognostic values different tumors, especially cholangiocarcinoma (CHOL), lymphoid neoplasm diffuse large B lymphoma (DLBCL), acute myeloid leukemia (LAML), thymoma (THYM)....
Laser powder bed fusion (L-PBF) has been used to fabricate biodegradable Mg implants of WE43 alloy, but the degradation rate is excessively rapid in as-built status. High temperature oxidation (HTO) employed successfully inhibit alloy. However, effect HTO on mechanical properties and biocompatibility not reported. In this work, influence L-PBF samples alloy was investigated regarding tensile, compressive, abrasive resistance, as well vitro cytotoxicity, cell proliferation, hemolysis,...