A5079073938- Bone Tissue Engineering Materials
- Lung Cancer Treatments and Mutations
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Distributed systems and fault tolerance
- Bone Metabolism and Diseases
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Agriculture, Soil, Plant Science
- Teleoperation and Haptic Systems
- Cancer-related molecular mechanisms research
- Geotechnical Engineering and Soil Stabilization
- Advanced Data Storage Technologies
- PI3K/AKT/mTOR signaling in cancer
- Innovations in Medical Education
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Geotechnical Engineering and Underground Structures
- Peptidase Inhibition and Analysis
Beijing University of Chinese Medicine
2022-2025
Zhejiang University
2021-2025
Jinan University
2012-2025
First Affiliated Hospital of Jinan University
2015-2025
Soochow University
2025
Soochow University
2025
Peking Union Medical College Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Australian National University
2024
Tianjin University
2009-2024
Antiosteoporosis gene-based drug development strategies are presently focused on targeting osteoblasts to either suppress bone loss or increase mass. Although siRNA/microRNA-based gene therapy has enormous potential, it is severely limited by the lack of specific cell-targeting delivery systems. We report an osteoblast-targeting peptide (SDSSD) that selectively binds via periostin. developed SDSSD-modified polyurethane (PU) nanomicelles encapsulating siRNA/microRNA delivers drugs...
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance antiangiogenic therapy. The current mechanisms underlying vessel have mainly focused on "hijacker" tumor cells, whereas the function of "hijackee" sinusoidal blood vessels not explored. Here, we found that occurrence in bevacizumab-resistant CRCLM xenografts was associated with increased expression fibroblast activation protein α (FAPα) co-opted hepatic stellate cells (HSCs), which...
Improper irrigation by Panax notoginseng growers can lead to soil consolidation, low fertilizer utilization, and decreased yield quality. In an attempt provide a scientific theoretical basis for cultivation improve microhabitat quality, field experiment were conducted on three-year-old in 2019, 2020, 2021. The experimental design consisted of two control factors, the amount (W) (F) applied. was set three levels, as W1, W2, W3, with exact volumes 5 mm, 10 15 mm. applied different all four...
Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as critical drivers of tumorigenesis therapeutic targets. Characterized by substantial accumulation histone H3 lysine 27 acetylation (H3K27ac) signals at loci cell identity genes oncogenes, recognized, bound activated BRD4, resulting in considerable oncogene over-expression, malignant transformation, cancer proliferation, survival, tumor initiation progression. Small molecule compound BD1 BD2 inhibitors block...
Background: Current drugs used for osteoporosis therapy show strong adverse effects. Stem cell-derived extracellular vesicles (EVs) provide another choice therapy. Mouse mesenchymal stem cells (mMSCs)-derived EVs promote bone regeneration; however, their clinical application is limited due to non-specific tissue targeting. Alendronate specifically targets via hydroxyapatite. Therefore, were combined with alendronate generate Ale-EVs by “click chemistry” facilitate targeting...
Abstract Long noncoding RNAs are widely implicated in diverse disease processes. Nonetheless, their regulatory roles bone resorption undefined. Here, we identify lncRNA Nron as a critical suppressor of resorption. We demonstrate that osteoclastic knockout mice exhibit an osteopenia phenotype with elevated activity. Conversely, transgenic lower and higher mass. Furthermore, the pharmacological overexpression inhibits resorption, while caused apparent side effects mice. To minimize effects,...
This study investigated whether programmed death-ligand 1 (PD-L1) expression of circulating tumor cells (CTCs) in peripheral blood can serve as a predictive biomarker for immunotherapy efficacy patients with advanced non-small-cell lung cancer (NSCLC).We employed negative enrichment method to isolate CTCs. We identified PD-L1 + CTCs PD-L1+/4',6-diamidino-2-phenylindole (DAPI)+/CD45-circulating through an immunofluorescence method. Tumor tissue was determined by immunohistochemical staining....
Abstract Sandblasting with large grit and acid‐etching (SLA) treatment is considered to be a reliable modification achieve excellent titanium surface. However, contamination of hydrocarbons would make SLA surface hydrophobic influence its bioactivity. Thus, appropriate methods preservation or further treatments could used for improvement. In present study, in deionized water (dH 2 O) ultraviolet (UV) irradiation were, respectively, applied modSLA UV‐SLA surfaces. Surface characteristics were...
Many challenges exist in improving early osseointegration, one of the most critical factors long-term clinical success dental implants. Recently, ultraviolet (UV) light-mediated photofunctionalization titanium as a new potential surface treatment has aroused great interest. This study examines bioactivity surfaces treated with UV light different wavelengths and underlying associated mechanism. Micro-arc oxidation (MAO) samples were pretreated UVA (peak wavelength 360 nm) or UVC 250 for up to...
Limiting water loss by reducing transpiration helps plants survive when is limited. Under drought stress, abscisic acid (ABA)-mediated gene expression and anion channel activation regulate stomatal closure stress responses. ABA-induced actin reorganization also affects closure, but the underlying molecular mechanism remains unclear. In this study, we discovered that under nonstress conditions, clade A PP2C phosphatases, such as ABI1 ABI2, interact with CKL2 inhibit its kinase activity in...
Abstract: Modifying the surface of transmucosal area is a key research because this process positively affects three functions implants: attachment to soft tissue, inhibiting bacterial biofilm adhesion, and preservation crestal bone. To exploit potential titania nanotube arrays (TNTs) with or without using bovine serum albumin (BSA) modify dental implant in contact area, BSA was loaded into TNTs that were fabricated by anodizing Ti sheets; physical characteristics these arrays, including...
Peripheral blood-based biomarkers (PBB) predicting response, survival and immune-related adverse events (irAEs) in patients with advanced non-small cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICIs) are still a matter of debate. Thus, we investigated the associations between PBB, efficacy ICIs incidence irAEs.Patients NSCLC, who had been at Peking Union Medical College Hospital received or chemoimmunotherapy from January 2015 to December 2020, were retrospectively...
Abstract Background Immune checkpoint inhibitors (ICIs) are the standard treatment for advanced lung cancer, but immune‐related adverse events (irAEs) remain poorly understood, especially in a real‐world setting. Methods A multicenter observational study was conducted. Medical records of cancer patients treated with ICIs at 26 hospitals from January 1, 2015, to February 28, 2021, were retrieved. Types included antiprogrammed cell death 1 or ligand (PD‐L1) monotherapy, anticytotoxic...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown cause and characterized by excessive proliferation fibroblasts the irregular remodeling extracellular matrix (ECM), which ultimately severe distortion alveolar architecture. The median survival IPF patients 2-5 years. are predominantly infiltrated M2 macrophages during course development progression. Predominantly accumulation accelerates progression secreting multiple cytokines that promote fibroblast to...