A5078181925- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Plant Physiology and Cultivation Studies
- Histone Deacetylase Inhibitors Research
- Cerebrospinal fluid and hydrocephalus
- Cancer Genomics and Diagnostics
- HIV-related health complications and treatments
- Postharvest Quality and Shelf Life Management
- Reproductive System and Pregnancy
- Angiogenesis and VEGF in Cancer
- Plant Stress Responses and Tolerance
- Plant Surface Properties and Treatments
Jinan University
2009-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
Shanghai Ocean University
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2008-2024
Mudanjiang Medical University
2019-2020
Northwest A&F University
2016-2019
Dalian Medical University
2018
Wuhan Union Hospital
2014
Background Increasing evidence suggests that many neurons may die through apoptosis in Alzheimer's disease (AD). Mitochondrial dysfunction has been implicated this process of neuronal cell death. One promising approach for preventing AD is based upon anti-apoptosis to decrease death nerve cells. In study, we observed the memory improving properties curcumin mice and investigated neuroprotective effect vitro vivo. Methods The were given AlCl3 orally injections D-galactose intraperitoneally 90...
Drought stress can negatively impact apple fruit quality and yield. Apple microRNAs (miRNAs) participate in tree development, as well biotic tolerance; however, it is largely unknown whether these molecules are involved the drought response. To identify drought-responsive miRNAs Malus, we first examined tolerance of ten F1 progenies R3 (M. × domestica) M. sieversii. We performed Illumina sequencing on pooled total RNA from both drought-tolerant drought-sensitive plants. The results...
Abstract Long noncoding RNAs are widely implicated in diverse disease processes. Nonetheless, their regulatory roles bone resorption undefined. Here, we identify lncRNA Nron as a critical suppressor of resorption. We demonstrate that osteoclastic knockout mice exhibit an osteopenia phenotype with elevated activity. Conversely, transgenic lower and higher mass. Furthermore, the pharmacological overexpression inhibits resorption, while caused apparent side effects mice. To minimize effects,...
Spinal cord injury (SCI) is one of the most common destructive injuries, which may lead to permanent neurological dysfunction. Currently, transplantation bone marrow mesenchymal stem cells (BMSCs) in experimental models SCI shows promise as effective therapies. BMSCs secrete various factors that can regulate microenvironment, called paracrine effect. Among these substances, exosomes are considered be valuable therapeutic factors. Our study found BMSCs-derived therapy attenuated cell...
Abstract Tumor-infiltrating T cells are highly expressive of inhibitory receptor/immune checkpoint molecules that bind to ligand expressed by tumor and antigen-presenting cells, eventually lead cell dysfunction. It is a hot topic restore function targeting immune checkpoint. In recent years, immunotherapy blocking its receptor, such as PD-L1/PD-1 targeted therapy, has made effective progress, which brings hope for patients with advanced malignant tumor. However, only few benefit from...
Abstract The development of new biomarkers or therapeutic targets for cancer immunotherapies requires deep understanding T cells. To date, the complete landscape and systematic characterization long noncoding RNAs (lncRNAs) in cells immunity are lacking. Here, by systematically analyzing full-length single-cell RNA sequencing (scRNA-seq) data more than 20,000 libraries across three types, we provided first comprehensive catalog functional repertoires lncRNAs human Specifically, developed a...
Lactate and protein lactylation serve a key role in tumor pathogenesis. Solute carrier 4A7 (SLC4A7), transporter, participates cellular acid homeostasis. However, its impact on lactate transport solid tumors, particularly lung adenocarcinoma (LUAD), remains largely unexplored. In the present study, lactylome analysis, Transwell wound healing assay, animal experiments were conducted to validate functional regulation mediated by SLC4A7 LUAD. inhibited progression, including metastasis,...
Sweet cherry ( Prunus avium L.) is one of the fruits that are widely acclaimed around world. However, its prone to cracking from onset color full maturity, especially in cherry-producing regions where rain events common near harvest. Cracked cherries have an unpleasant appearance, as well susceptible invasion by fungal pathogens, therefore dramatically depreciated, incurring considerable economic losses growers, quite dampening their planting enthusiasm, subsequently restricting advancement...
Alkaline soils have a great influence on apple production in Northern China. Therefore, comprehensive evaluations of tolerance to such stress are important when selecting the most suitable rootstocks. We used hydroponics culturing test 17 genotypes rootstocks after treatment with 1:1 Na2CO3 and NaHCO3. When compared normally grown controls, stressed plants produced fewer new leaves, had shorter roots shoots lower fresh dry weights 15 d exposure alkaline conditions. Their root/shoot ratios...
Abstract Background Colorectal cancer (CRC) ranks the third among most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations this disease. However, mechanism of miRNA-induced mRNA cleavage remains to be investigated. Method In study, high-throughput small RNA (sRNA) sequencing was utilized identify profile miRNAs from six pairs colorectal tissues (CTs) adjacent (CNs). Degradome (DS) employed detect...
Abstract Background Deep understanding the differentiation process of human embryonic stem cells (hESCs) is essential for developing cell-based therapeutic strategy. Substantial efforts have been made to investigate protein-coding genes, yet it remains lacking comprehensive characterization long non-coding RNAs (lncRNAs) during this process. Methods hESCs were passaged every 5–6 days and had maintained stable karyotype even until 50th generation. Pancreatic progenitor specification in vitro...
Abstract Human immunodeficiency virus type 1 (HIV‐1) infection in its human host often results progressive dementia and encephalopathy adults children, respectively. The mechanisms underlying virus‐induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory viral immune products from infected brain macrophages microglia affect the onset tempo of disease. One critical neurotoxin among these is HIV‐1 envelope glycoprotein gp120. To...
Ferredoxin 1 (FDX1) plays key roles in promoting elesclomol-induced cuproptosis against cancer, whether it has the potential to be a new therapeutic strategy glioblastoma not yet been clarified.
Curcumin improves the learning and memory deficits in rats induced by gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM loop μM curcumin for 24 hours. results showed that inhibited loop-induced mitochondrial membrane potential decrease, reduced mRNA expression of pro-apoptotic gene caspase-3, attenuated neuronal injury.
The purpose of this study was to investigate the expression and mechanism miR-17 in gastric lym-phoma. miR-17mimics, inhibitors negative controls were transfected into human lymphoma cell line cyp6d. proliferation, invasion apoptosis cyp6d cells detected by CCK-8, Transwell TUNEL methods, respectively. clinicopathological features analyzed real-time quantitative PCR. target gene predicted targetscan 7.2, related protein Western blot. results showed that significantly higher than normal...
Angiogenesis contributes to the growth of solid tumors. Antiangiogenic agents are widely used in various cancers and considerable efforts have been made development novel biomarkers that can predict outcome an anticancer treatment. Of those, circulating endothelial cells (CECs) their subsets constitute a surrogate tool for monitoring disease activity. However, owing lack standardization on phenotypes detection CECs subsets, results always inconsistent uninterpretable. In this review, we...
Osteoprotegerin (OPG) is a recently identified inhibitor of bone resorption. Recent studies indicated that OPG also acts as an important regulatory molecule in the vasculature. The purpose this study was to investigate change and its associations with endothelial function before after exercise training Hashimoto's thyroiditis (HT) euthyroidism. subjects included 62 newly diagnosed sedentary Chinese Han HT women euthyroidism 28 female healthy subjects. All individuals participated 6 months....
Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been to improve these effects some degree, but precise mechanisms remain unknown. The present study analyzed neuroprotective effect and mechanism of curcumin in relation hippocampal neurons. Results showed 1 nmol/L suppressed growth synapses. After administration μmol/L curcumin, synaptic improved. is against loop-induced neuronal...
Brain and reproductive organ-expressed protein (BRE) is aberrantly expressed in multiple cancers; however, its expression pattern human esophageal squamous cell carcinoma (ESCC) role ESCC progression remain unclear. In this study, we aimed to investigate the of BRE progression. was overexpressed tissues compared with that adjacent non-tumor tissues. Forced sufficient enhance growth by promoting cycle anti-apoptosis. Silencing suppressed these malignant phenotypes cells. Mechanistic...