A5033470436- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Vagus Nerve Stimulation Research
- Dermatologic Treatments and Research
- Plant-based Medicinal Research
- Systemic Sclerosis and Related Diseases
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Medical Research and Treatments
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
Second Affiliated Hospital of Xi'an Jiaotong University
2025
Peking University
2024
Peking University Third Hospital
2024
Peking University Shenzhen Hospital
2022-2023
University of Hong Kong - Shenzhen Hospital
2022-2023
Abstract Parkinson's disease (PD) is a common chronic central nervous system disorder that reduces quality of life and increases mortality. Currently, the treatment PD limited due to challenge macromolecular drugs crossing blood‐brain barrier (BBB). Black phosphorus (BP) has antioxidant anti‐inflammatory effects shows potential for neuroprotection. To solve restriction BBB, innovative BP microbubbles (BP@MBs) combined with focused ultrasound (FUS) are constructed facilitate BBB opening....
Inflammation is considered to be the main target of development new stroke therapies. There are three key issues in treatment inflammation: first one how overcome blood-brain barrier (BBB) achieve drug delivery, second select drugs treat inflammation, and third targeted delivery. In this study, we constructed hydrocortisone-phosphatidylserine microbubbles combined them with ultrasound (US)-targeted microbubble destruction technology successfully open BBB Phosphatidylserine on was used for...
Abstract Parkinson's disease (PD) is starting at younger ages. In order to reduce the risk of PD in young people, Rb 3 selected as an active ingredient and assembled into nanoparticles (Rb NPs)encapsulated microbubbles (MBs), shorted for NPs@MBs. This study uses focused ultrasound‐mediated NPs@MBs cross blood–brain barrier reach brain lesions be intervened explore prevention 1‐methyl‐4‐phenyl‐4‐piperidinpropionate ester (MPTP)‐induced by its related mechanisms. present study, prevent...
Abstract An important function of the blood–brain barrier (BBB) is to protect central nervous system and maintain its homeostasis, but it also a major intervention treatment neurological diseases. Our study aimed at opening BBB using noninvasive method, focused ultrasound, screening for 16 different parameter combinations frequency, peak voltage (Ppeak) irradiation time. Comparing results hematoxylin–eosin staining, serum oxidative damage factor TUNEL staining under various conditions, we...
Ginsenoside Rb3 nanoparticles (Rb3NPs) is a potential antioxidant for Parkinson's disease (PD) treatment. In Article 2300056, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng, and co-workers introduce phospholipid microbubbles encapsulated Rb3NPs (Rb3NPs@MBs) with low intensity frequency focused ultrasound to achieve brain targeted drug release. The treatment protects neurons from oxidative damage slows PD progression. article shows perfect combination of traditional Chinese medicine modern...