A5102861871- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ubiquitin and proteasome pathways
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Crystal structures of chemical compounds
- Peptidase Inhibition and Analysis
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Synthetic Organic Chemistry Methods
- Organometallic Compounds Synthesis and Characterization
- Cancer-related Molecular Pathways
- Synthesis and Reactions of Organic Compounds
- Computational Drug Discovery Methods
- Synthesis and Catalytic Reactions
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- Silicone and Siloxane Chemistry
- Sulfur-Based Synthesis Techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Liver physiology and pathology
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Catalytic Cross-Coupling Reactions
Huazhong University of Science and Technology
2024-2025
Beijing University of Civil Engineering and Architecture
2024
Nanjing University of Chinese Medicine
2018-2024
Jiangsu Provincial Academy of Traditional Chinese Medicine
2018-2024
China Pharmaceutical University
2013-2017
Huahai Pharmaceutical (China)
2016
Jinan Central Hospital
2013
Shandong University
2013
Xiamen University
1989-2005
Yale University
2003
We have found that the ubiquitin-proteasome pathway exerts exquisite control of osteoblast differentiation and bone formation in vitro vivo rodents. Structurally different inhibitors bind to specific catalytic beta subunits 20S proteasome stimulated organ cultures concentrations as low 10 nM. When administered systemically mice, epoxomicin inhibitor-1 increased volume rates over 70% after only 5 days treatment. Since has been shown modulate expression Drosophila homologue morphogenetic...
A [3 + 4] annulation of isatin N,N′-cyclic azomethine imine 1,3-dipole 1 with in situ-generated aza-oQMs has been established for the synthesis spirooxindole seven-membered scaffolds. These highly functionalized scaffolds were assembled moderate to good yields (up 96% yield). The novel displayed antitumor activities, which represented promising lead compounds drug discovery.
Abstract A novel synthetic method to access fused indolin‐3‐ones with a tetrasubstituted carbon stereocenter has been developed via NHC‐catalyzed umpolung formal [3+3] cycloaddtion of enals isatogens. This methodology could be also applied for the quick construction 6‐5‐5 tricyclic pyrrolo[1,2‐ ]indole skeleton which is frequently found as core structure many indole alkaloids. magnified image
A novel synthetic approach to functionalized indolo[2,3-<italic>a</italic>]quinolizidines is developed <italic>via</italic> an N-heterocyclic carbene-catalyzed annulation of cyclic β-enamino esters with enals.
c-Met has been considered as an attractive target for developing antitumor agents. The highly selective inhibitors provide invaluable opportunities the combination with other therapies safely to achieve optimal efficacy. In this work, a series of triazolopyrazine exquisitely selectivity were investigated using molecular docking, three-dimensional quantitative structure-activity relationship (3D-QSAR), and dynamics simulation. Comparative field analysis (CoMFA) comparative similarity index...
Metal-free C(sp<sup>3</sup>)–H alkylation of an isatin <italic>N</italic>,<italic>N</italic>′-cyclic azomethine imine 1,3-dipole.
A one-pot, two-step protocol for the synthesis of libraries remarkable functionalized sulfone analogues 9b,10,10a,10b-tetrahydro-1H-cyclopropa[c][1,4]thiazino[4,3-a]quinolines is described. class various molecular skeletons was obtained by cyclopropanation quinolinium zwitterionic thiolates. The reaction pathway involves formation a [2 + 1] cycloaddition intermediate followed [5 cycloaddition.
Aberrant activation of fibroblast growth factor receptors (FGFRs) has been identified as an oncogenic driver force for multiple cancer types, making FGFRs a compelling target anticancer therapy. Because the renewed interest in irreversible inhibitors, considerable efforts have made to find FGFR inhibitors. Herein, we discovered series novel quinolone-based covalent pan-FGFR inhibitors by further optimizing lead compound (lenvatinib) under guidance molecular docking. The representative...
Interleukin-10 (IL-10), a pivotal anti-inflammatory cytokine, has gotten attention for its involvement in tissue remodeling and organ fibrosis. Pleurisy subsequent pleural are recognized as quantifiable indicators of systemic lupus erythematosus (SLE) activity. However, the role IL-10 SLE-associated remains unknown. In this study, we investigated underlying mechanism. Clinical data serum specimens were obtained from SLE patients, while mesothelial cells mouse models served primary...
The tributylphosphane-promoted [3 + 2] annulation reactions of 3-hydroxyoxindoles with acrylates have been developed to give a variety pharmaceutically attractive spirocyclic oxindole-lactone derivatives in good excellent yields. structures all the compounds were confirmed by 1H NMR, 13C NMR and HRMS. This metal-free procedure features low costs reagents materials, mild reaction conditions, non-toxicity easy handling for scalable synthesis.