A5044930549- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Tryptophan and brain disorders
- Respiratory Support and Mechanisms
- Antibiotic Resistance in Bacteria
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Nosocomial Infections in ICU
- Bone health and osteoporosis research
- Respiratory viral infections research
- Pancreatic function and diabetes
- Skin Protection and Aging
- Genetic factors in colorectal cancer
- Air Quality and Health Impacts
- Neonatal Respiratory Health Research
- Gastroesophageal reflux and treatments
- RNA Research and Splicing
- Thermal Regulation in Medicine
- Ion Transport and Channel Regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Huazhong University of Science and Technology
2019-2025
Union Hospital
2019-2025
Jinyintan Hospital
2024
Hebei Medical University
2023
Wuhan Union Hospital
2020-2023
National Health and Family Planning Commission
2021
Tongji Hospital
1997-2020
Beijing Proteome Research Center
2017
Background Most patients including health care workers (HCWs) survived the coronavirus disease 2019 (COVID-19), however, knowledge about sequelae of COVID-19 after discharge remains limited. Methods A prospectively observational 3-month follow-up study evaluated symptoms, dynamic changes severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) IgG and IgM, lung function, high resolution computed tomography (HRCT) survivors at Wuhan Union Hospital, China. Results Seventy-six (55 females)...
Adverse skin reactions among healthcare workers during the coronavirus disease 2019 outbreak: a survey in Wuhan and its surrounding regions
Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is gradually recognized by more people. However, how long it will last and the underlining mechanism remains unclear.We conducted a prospective follow-up study to evaluate long-term symptoms clinical indices of RPs at one-year after discharge from Union Hospital, Wuhan, China between December 2020 May 2021. We also performed 16S rRNA sequencing stool samples healthy controls (HCs) analyzed correlation gut microbiota...
The current reports of COVID-19 focus on the respiratory system, however, intestinal infections caused by SARS-CoV-2 are also worthy attention. This paper reported persistence infection leads to re-admission after pneumonia resolved in three cases with COVID-19.
Most COVID-19 patients are moderate, and fever is the most common clinical manifestation associated with poorer prognosis. Gut microbiota may also play important roles in pathogenesis. However, association between gut individuals moderate remains unclear.We compared features laboratory results of 187 without identified several inflammatory markers fever. Then, we performed metagenome-wide study for 31 to identify microbes their epitopes which have potential role hyperinflammation.Among...
To evaluate the diagnostic performance and clinical impact of targeted next-generation sequencing (tNGS) in patients with suspected lower respiratory tract infections. Following propensity score matching, we compared performances tNGS metagenomic (mNGS). Furthermore, was that culture, its assessed. After coincidence rate comparable to mNGS (82.9% vs 73.9%, P=0.079). The detection rates for bacterial, viral, fungal, mixed infections were not significantly different (P>0.05). Bacterial-viral...
Under persistent inflammation, asymptomatic radiological bronchiectasis (ARB) may develop into clinical (CB). Although CB has been extensively studied, the potential for ARB to evolve remains largely unexplored. Whether could progress and risk factors speed up process are poorly understood. This was an observational cohort study. 370 patients with were included in Wuhan Union Hospital 2018. 296 followed 2022 verify if they progressed divided development validation of prediction models a...
Metastasis is the essential cause for high mortality of hepatocellular carcinoma (HCC). In order to investigate mechanism metastasis, and discover therapeutic targets HCC, quantitative proteomic technique was applied characterize plasma membrane proteins two HCC cell lines with low (MHCC97L) or (MHCC97H) metastatic potentials. One proteins, sodium-potassium-chloride cotransporter 1 (NKCC1), upregulated in MHCC97H line. Immunohistochemistry result patients showed that NKCC1 expression...
Abstract Objectives Evaluate the risk factors of prolonged SARS-CoV-2 virus shedding and impact arbidol treatment on shedding. Methods Data were retrospective collected from adults hospitalized with COVID-19 in Wuhan Union Hospital. We described clinical features RNA patients evaluated associated by multivariate regression analysis. Results Among 238 patients, median age was 55.5 years, 57.1% female, 92.9% (221/238) used arbidol, 58.4% (139/238) combination interferon. The time illness onset...
Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are the important pathogens causing pneumonia. This study aimed to investigate clinical characteristics molecular epidemiology of ESBL-producing E. K. pneumonia at a large teaching hospital in China.We collected patient's data strains (from December 2015 June 2016) Wuhan. The susceptibilities, multi-locus sequence typing, homologous analysis, ESBL genes by polymerase chain...
Pleural fibrosis is defined as an excessive deposition of extracellular matrix that results in destruction the normal pleural tissue architecture and compromised function. Tuberculous pleurisy, asbestos injury, rheumatoid pleurisy are main causes fibrosis. mesothelial cells (PMCs) play a key role However, detailed mechanisms poorly understood. Serine/arginine-rich protein SRSF6 belongs to family highly conserved RNA-binding splicing-factor proteins. Based on its known functions, should be...
The role of corticosteroids in the treatment Coronavirus disease 2019 (COVID-19) is controversial. In present study, we evaluated effects adjuvant on outcome patients with COVID-19 (n=966), using Propensity Score Matching to adjust for potential differences between group (n=289) and non-corticosteroids (n=677). Analysis data without adjusting baseline characteristics indicated that proportion mechanical ventilation mortality was higher total or severe/critical patients. duration viral...
BackgroundInfection is a major cause of morbidity and mortality after heart transplantation (HT). However, there have been few data on clinical manifestation, distribution, resistance pathogens in the infected population transplant recipients.MethodsWe conducted single-center retrospective study patients who underwent HT Wuhan Union Hospital from August 3, 2012 to July 30, 2016. Risk factors for infections that occur within 1 year were investigated by multivariable logistic regression...
Abstract Objectives : The role of corticosteroids in the treatment COVID-19 is controversial. In this paper, we intend to study application value corticosteroid critically ill patients with COVID-19. Methods We collected data from 120 who were diagnosed Wuhan Union Hospital. first part study, outcome given was compared that not corticosteroids. second a matched (1:1) case–control study. After matching baseline characteristics between two groups, effect use on analyzed again. Results Analysis...
Background Sputum nitrate/nitrite, which is the main component of reactive nitrogen species, a potential biomarker disease severity and progression in bronchiectasis. This study aimed to determine association between nitrate/nitrite exacerbations airway microbiota Methods We measured total concentration sputum samples collected from 85 patients with stable bronchiectasis, performed 16S ribosomal RNA sequencing predicted denitrification ability using Phylogenetic Investigation Communities by...
<title>Abstract</title> Background Tuberculosis infection (TBI) is an important cause of bronchiectasis (BE). Exploring the risk factors radiological BE (RBE) may improve identification high-risk populations RBE after TB infection. The present study aimed to develop a novel inflammation-nutrition score (INRS) and nomogram model identify population TBI. Methods recruited 2015 patients TBI from two centers. Patients (N = 1825) Wuhan Jinyintan Hospital cohort were used construct INRS model. In...
Acinetobacter baumannii is a multidrug-resistant coccobacillus responsible for severe nosocomial infectious diseases. This study mainly focuses on investigating the antimicrobial resistance features of clinically isolated strain (A. CYZ) using PacBio Sequel II sequencing platform. The chromosomal size A. CYZ 3,960,760 bp, which contains total 3803 genes with G + C content 39.06%. Functional analysis performed Clusters Orthologous Groups Proteins (COGs), Gene Ontology (GO), Kyoto Encyclopedia...