A5100729137- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Hepatitis C virus research
- Respiratory viral infections research
- Poxvirus research and outbreaks
- Virus-based gene therapy research
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Hematopoietic Stem Cell Transplantation
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- interferon and immune responses
- Research on Leishmaniasis Studies
- HVDC Systems and Fault Protection
- COVID-19 diagnosis using AI
- Vagus Nerve Stimulation Research
Wuhan Institute of Virology
2023-2025
Chinese Academy of Sciences
2023-2025
Hebei Medical University
2013-2024
National Institute for Viral Disease Control and Prevention
2012-2018
Ministry of Health
2013
China Agricultural University
1999
Institute of Hematology & Blood Diseases Hospital
1997
The ongoing pandemic caused by mpox virus (MPXV) has become an international public health emergency that poses a significant threat to global health. vaccinia Tiantan strain (VTT) was used vaccinate against smallpox in China 42 years ago. It is urgent assess the level of immunity individuals vaccinated 43 or more ago and evaluate their immunological susceptibility MPXV. Here, we recruited 294 volunteers detected residual humoral immunity, including vaccinia-specific IgG neutralizing...
The 2022 mpox outbreak led the World Health Organization (WHO) to declare it a public health emergency of international concern (PHEIC). There is need develop more effective and safer virus (MPXV)-specific vaccines in response epidemic. mRNA vaccine promising platform protect against MPXV infection. In this study, we construct two bivalent vaccines, designated LBA (B6R-A29L) LAM (A35R-M1R), quadrivalent vaccine, LBAAM (B6R-A35R-A29L-M1R). immunogenicity protective efficacy these alone or...
Assessing the long-term efficacy of MPXV vaccine candidates is crucial for global response to ongoing mpox epidemic. Built upon our previous study quadrivalent mRNA vaccine, herein we reported that MPXV-1103 could elicit sustained humoral and cellular immunity in mice, including induction A35/B6/A29/M1-specific IgG antibodies, VACV neutralizing antibodies activated cytotoxic CD8+T cells, which provides 100% protection against lethal challenge even at 280 days after first vaccination. Our...
Background Virus-specific cellular immune responses play a critical role in virus clearance during acute or chronic HBV infection. Currently, the commercially available vaccine is combined with alum adjuvant, which stimulates mainly Th2 responses. Therefore, development of new therapeutic adjuvants and strategies that also promote Th1 CTL urgently needed. Methodology/Principal findings To improve immunity induced by novel HBSS1 vaccine, we evaluated ability adjuvants, including alum, CpG...
As one of the deadliest viruses, Ebola virus (EBOV) causes lethal hemorrhagic fevers in humans and nonhuman primates. The suppression innate immunity leads to robust systemic replication EBOV, leading enhanced transmission. However, mechanism EBOV-host interaction is not fully understood. Here, we identified multiple dysregulated genes early stage EBOV infection through transcriptomic analysis, which are highly clustered Jak-STAT signaling. VP35 VP30 were found inhibit type I interferon...
Nipah virus (NiV) is a serious hazard to human health since it can cause severe respiratory infections and viral encephalitis with high fatality rate. Given the lack of licensed NiV vaccine, there an urgent need develop one protect public health. Previously, we developed G protein nanoparticle vaccines by loading onto ferritin nanoparticles (FeNP) via SpyCatcher/SpyTag technology, resulting in three layers (FeNP-SC/ST-Ghead), including inner core (20 kDa), intermediate layer covalently...
The induction of a robust neutralizing antibody (nAb) response is likely to be as essential specific cell-mediated immunity (CMI) against multiple antigens for the development effective preventive and therapeutic vaccines hepatitis C virus (HCV) infection in humans. To date, no data on immunogenicity replication-defective vaccinia (derived from Tiantan strain) (rNTV)-based HCV vaccine primates have been reported. This study describes detail various candidates rhesus macaques, including...
A therapeutic vaccine for chronic hepatitis B virus (HBV) infection that enhances virus-specific cellular immune responses is urgently needed. The "prime-boost" regimen a widely used strategy against many persistence infections. However, few reports have addressed this applying HBV development.To develop an effective vaccine, we constructed recombinant vaccinia (Tiantan) containing the S+PreS1 fusion antigen (RVJSS1) combined with particle-like subunit HBVSS1 to explore most prime-boost HBV....
Enteroviruses such as coxsackievirus B3 are identified a common cause of viral myocarditis, but the potential mechanism its replication and pathogenesis largely unknown. The genomes variety viruses contain N6-methyladenosine (m6A), which plays important roles in virus replication. Here, by using online bioinformatics tools SRAMP indirect immunofluorescence assay (IFA), we predict that CVB3 genome contains m6A sites found infection could alter expression cellular localization m6A-related...
ABSTRACT The outbreak of clade II monkeypox virus (MPXV) and the additional in Central Africa I from 2023 have attracted worldwide attention. development a scalable effective vaccine against ongoing epidemic mpox is urgently needed. We previously constructed two bivalent MPXV mRNA vaccines, LBA (B6R‐A29L) LAM (A35R‐M1R), quadrivalent vaccine, LBAAM (B6R‐A35R‐A29L‐M1R). These vaccines at 20 µg dose could induce potential antigen‐specific immune responses provide protection lethal VACV...
Stenotrophomonas maltophilia is an important multidrug-resistant pathogen that associated with various serious nosocomial infections. In our study, we investigated the antimicrobial resistance traits of clinical S. strain CYZ isolated from sputum immunocompromised patient. The whole genome sequence was using a PacBio RS II system. functions all predicted genes were annotated by COG, GO and KEGG databases. Several types antibiotics selected to test susceptibility, phylogenetic tree...
Chronic hepatitis B virus (HBV) infection is one of the leading causes hepatocellular carcinoma (HCC). The HBV genome prone to mutate and several variants are closely related malignant transformation liver disease. G1896A mutation (G A at nucleotide 1896) most frequently observed mutations in precore region HBV, which prevents HBeAg expression strongly associated with HCC. However, mechanisms by this HCC unclear. Here, we explored function molecular during HBV-associated remarkably enhanced...
The incidence of visceral leishmaniasis (VL), a global infectious disease, has been on the rise in China's Hebei province. When patients achieve clinical cure, they often do not reach an etiological which may lead to recurrence disease. Here, we report case with negative blood smear and bone marrow cytology.