A5101435671- Acute Myeloid Leukemia Research
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Streptococcal Infections and Treatments
- Poxvirus research and outbreaks
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Bacterial biofilms and quorum sensing
- Muscle activation and electromyography studies
- Cancer Research and Treatments
- Luminescence and Fluorescent Materials
- Protein Degradation and Inhibitors
- Nanomaterials for catalytic reactions
- Peptidase Inhibition and Analysis
- Neuroscience and Neural Engineering
- Chemical Synthesis and Analysis
- Cardiac electrophysiology and arrhythmias
- Herpesvirus Infections and Treatments
- Adsorption and biosorption for pollutant removal
- Neonatal and Maternal Infections
- Bacillus and Francisella bacterial research
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
East China University of Science and Technology
2023-2025
National Center for Drug Screening
2023-2025
Shanghai Institute of Materia Medica
2023-2025
Xinqiao Hospital
2023-2024
Army Medical University
2023-2024
Bioscience (China)
2024
Anhui Medical University
2023
Tianjin Medical University
2023
Tianjin Medical University Eye Hospital
2023
University of Houston
2023
The 2022 mpox outbreak led the World Health Organization (WHO) to declare it a public health emergency of international concern (PHEIC). There is need develop more effective and safer virus (MPXV)-specific vaccines in response epidemic. mRNA vaccine promising platform protect against MPXV infection. In this study, we construct two bivalent vaccines, designated LBA (B6R-A29L) LAM (A35R-M1R), quadrivalent vaccine, LBAAM (B6R-A35R-A29L-M1R). immunogenicity protective efficacy these alone or...
Haemophilus parasuis (H. parasuis) is a kind of opportunistic pathogen the upper respiratory tract piglets. Under certain circumstances, virulent strains can breach mucosal barrier and enter bloodstream, causing severe Glässer's disease. Many virulence factors are found to be related pathogenicity H. strain, but pathogenic mechanism remains unclear. LuxS/AI-2, as very important quorum sensing system, affects growth characteristics, biofilm formation, antibiotic production, virulence,...
The five-year survival rate of hepatocellular carcinoma (HCC) remains unsatisfactory. This reflects, in part, the paucity effective methods that allow target-specific diagnosis and therapy HCC. Here, we report a strategy based on engineered human serum albumin (HSA) permits HCC-targeted delivery diagnostic therapeutic agents. Covalent cysteine conjugation combined with exploitation host–guest chemistry was used to effect orthogonal functionalization HSA two functionally independent peptides....
We synthesized a trivalent galactosyl BODIPY probe for the super-resolution (STED) imaging of dynamic endocytic action asialoglycoprotein receptor (ASGPr).
Host–guest inclusion of a small-molecule fluorescent probe into human serum albumin enhances its sensitivity for ONOO − in aqueous solution and cells.
Abstract Uterine corpus endometrial carcinoma (UCEC), a prevalent kind of cancerous tumor in female reproductive system that has dismal prognosis women worldwide. Given the very limited studies cuproptosis-related lncRNAs (CRLs) UCEC. Our purpose was to construct prognostic profile based on CRLs and explore its assess value UCEC victims correlation with immunological microenvironment.Methods: 554 samples 23 normal samples’ RNA-seq statistics clinical details were compiled from data TCGA...
Dry eye disease (DED) is often secondary to diabetes mellitus (DM).
ABSTRACT The outbreak of clade II monkeypox virus (MPXV) and the additional in Central Africa I from 2023 have attracted worldwide attention. development a scalable effective vaccine against ongoing epidemic mpox is urgently needed. We previously constructed two bivalent MPXV mRNA vaccines, LBA (B6R‐A29L) LAM (A35R‐M1R), quadrivalent vaccine, LBAAM (B6R‐A35R‐A29L‐M1R). These vaccines at 20 µg dose could induce potential antigen‐specific immune responses provide protection lethal VACV...
Objective- This study aims to develop a novel framework for high-density surface electromyography (HD-sEMG) signal decomposition with superior yield and accuracy, especially low-energy MUs. Methods- An iterative convolution kernel compensation-peel off (ICKC-P) is proposed, which consists of three steps: the motor units (MUs) relatively large energy by using compensation (ICKC) method extraction MUs Post-Processor 'peel-off' strategy. Results- The performance proposed was evaluated both...
Fluorescence imaging is an emerging strategy for preoperative diagnosis and intraoperative resection. In particular, owing to their outstanding spatial resolution deep-tissue penetration, agents in the near-infrared (NIR)-II window (1000–1700 nm) have received intensive interest biomedical applications. However, NIR II-based targeted visualization of hepatocellular carcinoma (HCC) barely been developed. Here, we report construction structurally uniform, biocompatible human serum albumin...
An isoindoline-based fluorogenic probe bearing a self-immolative linker was developed for the sensitive and selective detection of O-GlcNAcase.
We have synthesized two sialic acid derivatives substituted with an ortho -nitrobenzyl alcohol (o-NBA) group that can undergo light-mediated conjugation primary amines at their 5- or 9-carbon position.
The objective of this study is to establish a novel and more efficient in vitro cell-based bioassay method for the evaluation bioactivity teriparatide. Firstly, different concentrations PTH1-34 were used stimulate rat osteosarcoma cell line (UMR-106 cells), intracellular cAMP levels quantitatively measured using time resolved fluoroimmunoassay(TRFIA) reflect biological activity PTH1-34. relative potency samples was calculated four-parameter fitting analysis. Subsequently, experimental...