A5100678603- Cystic Fibrosis Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Digestive system and related health
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Kruppel-like factors research
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
- Immune cells in cancer
- Cancer Research and Treatments
- Genetic Associations and Epidemiology
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Ion Transport and Channel Regulation
Linyi People's Hospital
2016-2024
University of Missouri
2008-2024
Affiliated Hospital of Chengde Medical College
2023-2024
Tianjin Medical University Eye Hospital
2020-2024
He Eye Hospital
2024
Nanjing Medical University
2024
Peking University First Hospital
2019-2024
Peking University
2019-2024
University of Chinese Academy of Sciences
2024
Institute of Genetics and Developmental Biology
2024
Estrogen has been reported to prevent development of cardiac hypertrophy in female rodent models and humans. However, the mechanisms sex steroid action are incompletely understood. We determined cellular effects by which 17β-estradiol (E2) inhibits angiotensin II (AngII)-induced vivo. Two weeks infusion mice resulted marked left ventricle, exacerbated loss ovarian hormones from oophorectomy. Hypertrophy was 51% reversed administration E2 (insertion 0.1 mg/21-d-release tablets). The were...
Although the efficacy of pharmacotherapy for tobacco dependence has been previously demonstrated, there is substantial variability among individuals in treatment response. We performed a systems-based candidate gene study 1295 single nucleotide polymorphisms (SNPs) 58 genes within neuronal nicotinic receptor and dopamine systems to investigate their role smoking cessation bupropion placebo-controlled randomized clinical trial. Putative functional variants were supplemented with tagSNPs each...
Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. mice show augmented intestinal proliferation of unknown etiology an altered environment. We examined the role cystic transmembrane conductance regulator (Cftr) in Wnt/β-catenin signaling, stem cell proliferation, its functional expression active (ISC) population. Dysregulation intracellular pH (pHi) ISCs was investigated facilitation signaling.Crypt epithelia from wild-type (WT) were compared...
Objectives To investigate the qualitative and quantitative characteristics of contrast‐enhanced ultrasound (CEUS) in assessing cervical lymph node metastasis from papillary thyroid carcinoma (PTC) to evaluate its value preoperative diagnosis PTC. Methods A total 55 nodes 46 patients were enrolled retrospectively, including 29 metastases PTC 26 normal/reactive ones. All evaluated by conventional (US) CEUS before biopsy or surgery. receiver operating characteristic curve analysis was used...
LGGs promoted intestinal MUC2 production through regulating S100A10/5-HT4R and the gut microbiota.
Purpose: Corneal injury (CI) resulting in corneal opacity remains a clinical challenge. Exosomes (Exos) derived from bone marrow mesenchymal stem cells (BMSCs) have been proven effective repairing various tissue injuries and are also considered excellent drug carriers due to their biological properties. Recently, microRNA-29b (miR-29b) was found play an important role the autophagy regulation which correlates with cell inflammation fibrosis. However, effects of miR-29b on CI remain unclear....
Physiological studies of intact crypt epithelium have been limited by problems accessibility in vivo and dedifferentiation standard primary culture. Investigations murine intestinal stem cells recently yielded a culture three-dimensional gel suspension that recapitulates structure epithelial differentiation (Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, Van Es JH, Abo A, Kujala P, Peters PJ, Clevers H. Nature 459: 262–265, 2009). We investigated the utility cultures...
Cystic fibrosis (CF) intestinal disease is associated with the pathological manifestation mucoviscidosis, which secretion of tenacious, viscid mucus that plugs ducts and glands epithelial-lined organs. Goblet cells are principal cell type involved in exocytosis mucin granules; however, little known about exocytotic process goblet CF intestine. Using organoids from a mouse model, we determined have altered dynamics, intrathecal granule swelling was abruptly followed by incomplete release...
Association studies among admixed populations pose many challenges including confounding of genetic effects due to population substructure and heterogeneity different patterns linkage disequilibrium (LD). We use simulations investigate controlling for by indicators global ancestry the impact a covariate local ancestry. In addition, we an interaction term between single-nucleotide polymorphism (SNP) capture in SNP effects. Although adjustment can control confounding, additional may increase...
An efficient approach to characterizing the disease burden of rare genetic variants is impute them into large well-phenotyped cohorts with existing genome-wide genotype data using sequenced referenced panels. The success this hinges on accuracy variant imputation, which remains controversial. For example, a recent study suggested that one cannot adequately HOXB13 G84E mutation associated prostate cancer risk (carrier frequency 0.0034 in European ancestry participants 1000 Genomes Project)....
// Jiang Chen 1, 2, * , Tong Ji Jie Zhao 2 Gaofeng Li Jian Zhang 1 Renan Jin Jinghua Liu Xiaolong Xiao Liang Diyu Huang Anyong Xie 3 Hui Lin Yong Cang Xiujun Cai Department of General Surgery, Sir Run Shaw Hospital, College Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China Life Sciences Institute and Innovation Center for Cell Signalling Network, 310029, Translational These authors have contributed equally to this work Correspondence to: Cai, e-mail: cxjzu@hotmail.com Cang,...
Abstract Background: Recent work detected for the first time a high-risk prostate cancer mutation, in homeobox B13 (HOXB13) among European-Americans. Methods: We further evaluated this G84E missense mutation (rs138213197) two genetic association studies of cancer: family-based study brothers and case–control more aggressive disease (N = 2,665 total). then calculated overall impact by pooling all published Results: In our studies, was found exclusively men with (carrier frequency 1.48%) or...
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl(-) and HCO3 (-) efflux across apical membrane of epithelium. In intestine, manifests as obstructive syndromes, dysbiosis, inflammation, increased risk gastrointestinal cancer. Cftr knockout (KO) mice recapitulate intestinal disease, including hyperproliferation. Previous studies using KO organoids (enteroids) indicate that crypt epithelium...
Background: Traditional observational studies have found a possible risk association of the gut microbiota for psoriasis. Meanwhile, psoriasis may also affect changes in microbiota. However, available evidence does not demonstrate reciprocal relationship between and This limits our understanding on role mechanisms Methods: To address this question we used Mendelian randomization, novel epidemiological approach, acquired largest current GWAS data from MiBioGen consortium as well FinnGen...
Methionine sulfoxide reductase B1 (MsrB1) is a member of the selenoprotein family, which contributes to reduction methionine sulfoxides produced from reactive oxygen species (ROS) by redox processes in energy pathways. However, few studies have examined role MsrB1 human hepatocellular carcinoma (HCC). We observed that highly expressed HCC tissues and its expression correlated with prognoses patients after hepatectomy. In vitro, knockdown inhibits cell growth MTT EdU proliferation assay,...